ID A0A1I8P482_STOCA Unreviewed; 1035 AA.
AC A0A1I8P482;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 33.
DE RecName: Full=Centaurin-gamma-1A {ECO:0008006|Google:ProtNLM};
GN Name=106091347 {ECO:0000313|EnsemblMetazoa:SCAU004692-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU004692-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU004692-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU004692-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR RefSeq; XP_013113293.1; XM_013257839.1.
DR AlphaFoldDB; A0A1I8P482; -.
DR STRING; 35570.A0A1I8P482; -.
DR EnsemblMetazoa; SCAU004692-RA; SCAU004692-PA; SCAU004692.
DR GeneID; 106091347; -.
DR KEGG; scac:106091347; -.
DR VEuPathDB; VectorBase:SCAU004692; -.
DR OrthoDB; 1449795at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08836; ArfGap_AGAP; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 473..677
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 674..817
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 857..889
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 243..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 112453 MW; 500D6F4EC8B0B0EF CRC64;
MLAVKNFFLP ERTKAPDTPQ RFSRMPEAFL RSIRRRSLRV KRAKSLVVPD REKRKSDSFV
NSQEWTISRS VPDLRLGIVG SLNSGKSALV HRYLTGSYMQ EESPEGGRFK KEVFIDGQSY
LLLIRDEGGA PEMQFAAWVD AVIFVFSLEN ESSFNTVYNY YTKMAHFRNG QEIPMILVGT
QDAISERNPR VIDDSRARKL ANDLKRCSYY ETCATYGLNV ERVFQDACQK ILSQRLPLPA
AVVTSRPTTP QGTRLGIASY HHNSSSNGSA NANGFSSTNS SSNSMQSGGG SSGASGVSAS
ASSGAGNLTL PHRHHALSSS THHIPMRMSA DFVHSEQQHS LPPVGNPSST AQKLWQQQHQ
QQQQDSQHVQ LRSHHNRDRE YALTNENNNI TKYNAQGGGV TGTAAEQLAP LSLVPLREKD
SNMGGGGKDL PTPTSTPTAS RKSRRRSNLF IPSSSKKGEK DMKNGELGSG RSIPIKQGYL
YKRSSKSLNK EWKKKYVTLC DDGRLTYHPS LHDYMDDVHG KEIPLQYVTV KVPGQKPRGS
KSIITNSALT TSMLSTNNVF EPLKESAVKS NSSQQTSGDE GIAMSNSNSQ TFLAVSGENA
QRELLAVNAS NKLEAQTPNV KKRHRRMKSS SVKSNEIDDS DGYEFYIVSL DSKQWHFEAA
NSEERDEWVA AIEQEIFKSL QSIESTKLKP ATTSELASMV TIRTRVPGNG YCVDCDAPNP
EWASLNLGVL MCIECSGVHR QLGSHISKVR SLGLDDWPAG HLSVMLAIGN SLANSVWEAN
TRQKSKPKPN TSREEKEAWI RSKYEAKEFL PPPNTNTNAT PGQQLIEAVI RSDMKSIVLI
LANATPEVTN ANVSPRDVRT PLLLACAIGN LAISQLLIWN GANIKHTDHE GRTCLAYARA
AQSLATAKSL KAAAAKCSTS NNSSSLASNT SSSSSSTSQS TSTNTNSASN SVNTGAAAAC
QPSASSAAAT TTTTTSTANG GIPAPHYSVE ETTSLVELLT GLGCPESAPL TASGTLPRRR
DTLGTPYEKT VSGVI
//
