ID A0A1I8PAF1_STOCA Unreviewed; 1244 AA.
AC A0A1I8PAF1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=106094741 {ECO:0000313|EnsemblMetazoa:SCAU006286-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU006286-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU006286-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU006286-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR RefSeq; XP_013117433.1; XM_013261979.1.
DR AlphaFoldDB; A0A1I8PAF1; -.
DR STRING; 35570.A0A1I8PAF1; -.
DR EnsemblMetazoa; SCAU006286-RA; SCAU006286-PA; SCAU006286.
DR KEGG; scac:106094741; -.
DR VEuPathDB; VectorBase:SCAU006286; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF47; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 712..734
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 746..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 797..817
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 829..850
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 911..929
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 949..969
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 999..1017
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1098..1117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1124..1143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1168..1187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1194..1214
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 292..612
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 683..1176
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 139416 MW; 2D407B1AE6C0860C CRC64;
MSFSGQGSSD NKRKLSFLGF NTKKSGGNED PNEVLLDSEM EKVFAGPSTL KEKFDVTTFQ
DTVLPLPGSF KNIVNVSRKN LPGELNIEEH TDFDHNSEPS NAQNYDDIPE DFPLVSERAG
HGDHSDNSAD EKHVQFGKKK ASVVTPPNLS YDEQPNDNLH ERKRRKSRIQ YYRQRKFSHQ
DSVEAKKVSE ENGDAGNRKI SAPEDAALEE ADLNELRSHR SDDPRALRRH KIHHSSIKLR
ELPQISVAGL QQAKKAFDHS PHEIFVQLDE LTGSGEDREW KETARWIKYE EDVQEGSDRW
GKAHVSSLSF HSLLNLRRCL ETGVVLLDLN EKDLPAVAYR VVEQMVVDDL IHTDDKPSVL
RSLLLRHRHV NENQSGFPFT KRKYNSYTSL QLLLLGSENN NHQHMQMQQR NRGNAQTRRS
ICETLSAPPP IAVAIEPSCR RHSTMSYMGN LSGDDKKIKI MPALEIGGSK KSNDLKIDMK
DDMYSSSQED LKKLQNDTIL KRIPHGAEAT TVLVGAVDFL EQPTIAFLRL AEGVPMPSLT
EVPIPVRFMF ILLGPPNYDL DYHEVGRSIA TLMANESFHG IAYSADDRKD LLSAINEFLD
DSIVLPPGNW DRHDLLPFEE LKAKKDWIRS RKTKALQNKK ELKELKEKQA GSELTTALVE
KKPDDEDDDG EKKKPSPLEK THRLWGGLRN DLKRRLPMYR SDIMDGLNTE TLAATIFMYF
ACLSTAITFG GLASDKTHNL IGISETLLSA SVVGVIFHTF AGQPLVIIGT TGPLLLFDEA
LNNFCKENNI SFLTIRAYIG IWLGVIAILV SAFEGSVYVR LLTRFTQEIF SALITLIYIV
ETIMKLVSVY KKHPLLADYN LPPPTIAGGR LDGDNSTLDT LNDAQDGSNV TTNNTLAIDL
GNQAPLNMPN TALFCTILTL GTFTVAYYLK LFRNSHFLGR NARRALGDFG VPISITIFVM
VDYFIPQVYT EKLSVPEGIS PSDPVNRGWL VSLGPVETWL PFLAGIPALL VYILIFMESH
ISELIVDKPE RGLKKGSGLH FDIVLLCCLN TLCGFFGMPW HCAATVRSVA HVSALTIMSR
THAPGESPRI IDVKEQRLSG FFVALMIGLS VTMAPLLRLI PMAVLFGVFL YMGVASMSGV
QFFERVKLFF MPVKHYPPTP YVRKVPTWKM HMFTAIQVGC LALLWAVKSS KISLAFPFFL
VMMVPIRMKL GSMYKPQEIA ALDGSEAKPD EDEPDFYEEA TIPA
//
