ID A0A1I8PF98_STOCA Unreviewed; 3165 AA.
AC A0A1I8PF98;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Bromodomain adjacent to zinc finger domain protein 2B {ECO:0008006|Google:ProtNLM};
GN Name=106091376 {ECO:0000313|EnsemblMetazoa:SCAU007584-PF};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU007584-PF, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU007584-PF}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU007584-PF};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR RefSeq; XP_013113373.1; XM_013257919.1.
DR EnsemblMetazoa; SCAU007584-RF; SCAU007584-PF; SCAU007584.
DR VEuPathDB; VectorBase:SCAU007584; -.
DR OrthoDB; 2912910at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd15545; PHD_BAZ2A_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF2; IP14655P-RELATED; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 944..1017
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1250..1313
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 2525..2575
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2579..2631
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 3073..3143
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1493..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2086..2129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2454..2481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2631..2753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2945..2967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2999..3034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2089..2112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2454..2473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2640..2667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2687..2753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3007..3024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3165 AA; 339171 MW; C85B72097B475D02 CRC64;
MKNMDKNAGE GGQQNDGGGG GGGGGKGGGG GGKGSANSGA GAAGAHDQAA LLDAASLFAY
WGRDPASAAA AATNPLFNAQ FNAAAAAGLG LLPNPTGGGS ANDRYSMAAA AAAAAAGHHH
QNTMAVAASQ AASLASLHPA NWWAVTQLAA QDYFNRLQAS GLTHFPHADL AAAFNPAALG
LAGAAGAGGG SGGVGGAGGS GGQNANSSGN SGSAGGNSNS SGSKSSSKSR KEKQRQQQQQ
QQLQQQQQQQ QSLANSLNAA AAAAAAAVAA NPAAALSSMH GLVGAGTTIT PSSGLGSSAG
SGSNNSGSSS NAYKNNSSNF GKSSSSSSNP IQVQLPPPPG SAYDPVQLHK ELLAMQQAAA
AAAASGAPSS SKKSSSKQSN NNSSSSANLI SPHGSMGGGG SGGGGAGGGG SNSSSSSSSR
DKNAADKNNA SLNALNSLSQ FGALCMTPQQ SMQAAMNAFA ASNSAAAAAA AAATSGNNSG
GGGSASSTTG GNNKSSKDFI PSGGLGDHPS LLGVRLPPDT EIIKYTSSIV GPKIPGTTSR
GRKKTISDEQ NQLQQQKLDL DSTTNALSSL LAFPGLSPAK RARLEMEYAA IAAAANAAQQ
QHQQQSAAAG AGGVGGSGVG GAVGSSSSTG LPGNLTASQM AALSGSLGAS VNTATPGSST
SGGSSQNTPH LDLTGPSSGR TSRDSSTDRV EVIKLPPTIT SNGAYNLSNK NKDVHDLTGG
TDLNSGVNLS LKPAASAVSN STHGAGGNVT GTTITIDDFD APLNLSMKPD KSSSSSNDLS
GGNSSSVSGG GSGNSGASSL QSLSSITAAL GGNGSAGGSS GGSGAAGNSS SMGGNGSSNS
SSNNAANDRS SQQSSSFKEG RPRNLGRGVS KPKKNTVASL LAQSRAVGIK PMLATQQLLQ
QGADIEKIRQ ALSEANAQME VSTDSESVAA ESGLSESETE EPNLLNVTEL RIPLDLGWKR
ETVIRGLTKA GQIKGEVTYY APGSNVPIKS IGQVFAHLDK NPSKLLRENF SFSARAIVGT
FLQPAPPPYA NDGEYIRMTD EDVAKRLEDL KIFTRQTLNV EERIQIAKQQ QALRDAKKAQ
KEEMARSKEK ARQEKNEKLE QQKRERELKN QQAIEARKKK QEELERLKQE EILKKQQEKE
KKRQEAILAK EQELNRQKEL LLAAEMERER RRQHMNLIRQ LEVRRKFEER EKKKHQMVLD
RLIMREKRLA ARKRDAEILA QIRKPQEDSE LIQPNPIPEL ERIAGNRLPG QAMADLLMVF
EFLHNFGETL GFDMESLPTL QNLHDALVSD SNADAEEELL SVMTHLLVCA IEDPGIPNPG
RHTTLLGQSL RNADITNSNV AEILRIYLYA TATGEIRQMF GVVMDRERER RVPDHHQIDS
ESVVHTGKNA EYYKLLHENE TWKLSMALKD RPFVALNPTK KAQILAHLCN DLLMNKAVLK
QIESSLDTCN QMRKEKYMTD MKVRKYKALH MRKSRIEAYE KLQAEREAAM QAMAAQQKLD
AERMEKENAD GNKDGGAATT VDHENPNNPN STLEQTSTEA AGGEQNNNAN NKDESMEVDG
GESAQKQLLD KDLTNLPGAA LDDAKLMALT SDITPTKMPK LDDLSATSYH NGGSKVSGGR
SVGGLNDDAC TDGGMDEDMS DMESEITNVE EDEDNRLSAD ELQKKLDKII RANLNCKEVL
EKSTNQLRAT CFGQDRFWRR YWRLPKAGGI FIEALESAQN DIFQYNQILE QEDEERRLNQ
PPEQEVPVEE SELPKASEDN EAPCEINNDV EMKNAEVTVS NVASSAAECA NMVNTTSGNA
ETNADDSDDD VIETNRVEPE IVDLRDDDDD DYDVAIKPQA IQIDNNGTAK VEKPDAAGLL
PPPPPPISSS SAANVTCTSP TANNSNPPKK EDFESDVKLG AGGVGGTLNP SQISLTTNCD
KSEITNMINN TNAPTGLAAT TPTSTINSSP TIKVDPMKVI DDKKEDDCII VSSSGPAECK
PLMQPPEPQD KWFSIVNREV PLTTTEPQNA TNLKEFQKLY SNITCSSSYQ IQGHPWDLPN
NVQYFTVTMD DCKADLSKLT TECIVSLSGL DQDEIDKKLK EFEEKLQQNS KNSLETPRHH
QMSSSSMKTE GETTDNMDCD DEEVGEEHLD KKSLVKNESD SKFFHFAKDE AIDSGGGGDA
TDCYDIKPKL EIKLDEALQT SLQNMHNMSL TNISNFIQYD VPTPLQMSLE ESQKLELIKK
EGFPKKVNNS FVPHNLRYNW WKIDTMELLQ QVINSLNSSG LREKELKENL TRFLSQEIPL
GLPYAFGEAK ESDQPFVMPD KPNDWTPKIA KRVEMALLEQ LEALEDKIAS ASMQLKNWAL
PPRIESELNL ESDADITEED FVSIIPMIRE RIIDLEANIE RRYLKPPLGA HTGDAHLAAI
AQNQQNTQTQ NSANAAAYYQ QMQQQQAAAQ QQQQAFNPSA FNERAMALAA ANNTENNSQT
HNENNSGGDS PSSNCDSDKD EKVENIPKGL VSWRDAVSRS HTTAQLAMAL YVLESCVAWD
KSIMKANCQF CTSGENEDKL LLCDGCDKGY HTYCFKPKMD NIPDGDWYCY ECVNKATNER
KCIVCGGHRL PPVGKMIYCD LCPRAYHADC YIPPLLKVPR GKWYCHGCVS KAPPPKKRSS
SSKPRRDRDS SSTSLSSKRK DKHHNTSSSC EQLNTSTDHH NLHNSSHDES MTSLPPPLSP
AHSVASTSYD DHHNNSIDTT RFQNQVTNRQ SVLSPQPNNE YNDTSMDGNA INNPAAANIN
AATNHGLLLA TQQQHQQHQQ TQHMQQQQLL NSQLPGGIAT LSNPNPLIAQ QPAMSLPLTM
PQQQQLFNSM APGTLLPPQP PQTMSPSLFA NLAASVPPHP SMAAANQSNH LAPFAMNAAV
VGTSLIQPPP PTAVTTVSVA MPAQMPPVSN QPMPIIPSQL PISINMPILS TATLPTSMTT
APTVSSLMCS TSPQHSLTSP RSSTPTQSQA MLYNAVPLQQ QLQMHQQQPQ HSPQLLGTPA
AVASAAATSP AMTSPSLTSP IASSTALGPP PPLNIHAVQE AKEKMKQEKK EKHATKKLMK
ELAVCKTVLG EMELHEDSWP FLLPVNTKQF PTYRKIIKNP MDLSTIKKRL QELSYKSRED
FCVDVRQIFD NCEMFNEDDS PVGKAGHGMR KFFEMRWAEL TDKHS
//
