ID A0A1I8PFH5_STOCA Unreviewed; 648 AA.
AC A0A1I8PFH5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=106087249 {ECO:0000313|EnsemblMetazoa:SCAU007643-PD};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU007643-PD, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU007643-PD}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU007643-PD};
RA Wilson R.K., Warren W.C., Olafson P.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SCAU007643-PD}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU007643-PD};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU361242}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323,
CC ECO:0000256|RuleBase:RU361242}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680,
CC ECO:0000256|RuleBase:RU361242}.
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DR RefSeq; XP_013107677.1; XM_013252223.1.
DR RefSeq; XP_013107679.1; XM_013252225.1.
DR RefSeq; XP_013107680.1; XM_013252226.1.
DR RefSeq; XP_013107681.1; XM_013252227.1.
DR RefSeq; XP_013107682.1; XM_013252228.1.
DR RefSeq; XP_013107685.1; XM_013252231.1.
DR AlphaFoldDB; A0A1I8PFH5; -.
DR STRING; 35570.A0A1I8PFH5; -.
DR EnsemblMetazoa; SCAU007643-RA; SCAU007643-PA; SCAU007643.
DR EnsemblMetazoa; SCAU007643-RB; SCAU007643-PB; SCAU007643.
DR EnsemblMetazoa; SCAU007643-RC; SCAU007643-PC; SCAU007643.
DR EnsemblMetazoa; SCAU007643-RD; SCAU007643-PD; SCAU007643.
DR EnsemblMetazoa; SCAU007643-RE; SCAU007643-PE; SCAU007643.
DR EnsemblMetazoa; SCAU007643-RF; SCAU007643-PF; SCAU007643.
DR GeneID; 106087249; -.
DR KEGG; scac:106087249; -.
DR VEuPathDB; VectorBase:SCAU007643; -.
DR OrthoDB; 202750at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF140; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361242};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|RuleBase:RU361242};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361242};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361242}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361242"
FT DOMAIN 517..640
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT REGION 80..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 73895 MW; D97922B5D94F6DB7 CRC64;
MSSLSLTRKL RGRMRSNTCR IVLLTSLVWV IVDFVLIAHY SDCIGKDGWR CKRSGEYDVE
LPVAERRVDE EMVGDNEIDT EKNIDNDVGG GGGGGIGGSV GSRSGGDSFV GEIGHGFVSG
GISPTYRSTT LRKWYVAPTV REQKGKPGEM GKPVKIPNEM KELTKEKFKE NQFNLVASDM
ISLNRSLTDV RHENCKKKHY PSKLPTTSIV IVFHNEAWTT LLRTVWSVIN RSPRALLKEI
ILVDDASERD YLGKKLEEYV ATLPVHTFVL RTQKRSGLIR ARLLGAEHVT GEVITFLDAH
CECTEGWLEP LLARIVQNRR TVVCPIIDVI SDETFEYITA SDSTWGGFNW KLNFRWYRVP
QREMERRNND RTAPLRTPTM AGGLFSIDKE YFYEIGSYDE GMDIWGGENL EMSFRIWQCG
GILEIIPCSH VGHVFRDKSP YTFPGGVAKI VLHNAARVAE VWLDEWRDFY YAMSTGARKA
SAGDVSERRA MRERLKCKSF RWYLENIYPE SLMPLDYYYL GEIRNAEMET CLDTMGRKYG
EKIGMSYCHG LGGNQVFAYT KRQQIMSDDL CLDASQSLGP VNMVRCHNMG GNQEWVYDAE
DKSIRHTNTG NCLQRPSRED PTTPLLRPCN YSRGQQWLME SKFKWQAH
//
