ID A0A1I8PFM6_STOCA Unreviewed; 2120 AA.
AC A0A1I8PFM6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=106086320 {ECO:0000313|EnsemblMetazoa:SCAU007637-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU007637-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU007637-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU007637-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_013106404.1; XM_013250950.1.
DR STRING; 35570.A0A1I8PFM6; -.
DR EnsemblMetazoa; SCAU007637-RA; SCAU007637-PA; SCAU007637.
DR GeneID; 106086320; -.
DR KEGG; scac:106086320; -.
DR VEuPathDB; VectorBase:SCAU007637; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR CDD; cd18659; CD2_tandem; 1.
DR CDD; cd17993; DEXHc_CHD1_2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR025260; CHD1-like_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF13907; CHD1-like_C; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01176; DUF4208; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 419..513
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 538..599
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 638..808
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 938..1089
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1492..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1736..2120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1576..1592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1609..1627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1747..1764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1809
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1875..1901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1903..1955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1965..2017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2099..2120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2120 AA; 237437 MW; 08D91EB6C8E8F625 CRC64;
MSQEHNESLN SIGSEENDDT REDEHNDGSG SGSGSSSESD SDSDSSSSSS NSSGGGRSSP
EPPDRDEEDD NARDGHNSQQ QQQHDSNYRL EQEEKQKQFA EAGLPPSAIE AQDDTKTNTN
GYSDDNDSGS ESGSNSDSNS SNDDDDDDEK ASQQNDVRGR DGQGNHDAEH KQQNTTHNTT
GTSFTSATTD NNTSHTTNDE DDSNDSNDSE DSNSDNEETQ TSQPMVTDET TTPPTTASEA
IKQQHNSDEN EDEASDSAES AKSSNSSAHS ATESNSSSSS SSEDTEEDYQ PKRSARQARK
PQPAAEKSKK PLKKKKRSQN WNSDESDESD EESEDSSPPP RRKPPAKQNK AQKRNKKSSA
STDESGEDSK RFGTRRAAAT VSYKEDTDKT DSDDLVEIEY DESQAEAAAL AAEEDEKCET
IERILYKRQG KKGCTGNQTT IYAIEESGCD PNDGVDENDL ENTEVQYLIK WKGWSYIHNT
WESDATLKEQ KVKGMKKLDN FIKKELEQVY WMRHAGPEDI DYYECQKELQ NDLIKSYNNV
DRIIARNVKP EGPVEYLCKW QSLPYAEATW EDGALVMRKW KRCVEQFEER ENSKCTPSRH
CKVLKNRPKF YKIKNQPEFL SEGLVLRDYQ MDGLNWMLHS WCKENSVILA DEMGLGKTIQ
TICFLYSLFK VHHLYGPFLC VVPLSTMTAW QREFDLWGPD MNVVTYLGDV KSREMIRQYE
WTFDGSKRLK FNCILTTYEI VLKDKLFLGT LQWAALLVDE AHRLKNDDSL LYKSLKEFET
NHRLLITGTP LQNSLKELWA LLHFIMPEKF VTWEDFELEH GNAADKGYTK LHQQLEPYIL
RRVKKDVEKS LPAKVEQILR VEMTSLQKQY YKWILTKNFD ALRKGKKGST STFLNIVIEL
KKCCNHAALI RPSEFELMGM PQDEALQTLL KGSGKLVLLD KLLCRLKETG HRVLIFSQMV
RMLDILADYL QKRHFSFQRL DGSIKGEIRR QALDHFNAEG SQDFCFLLST RAGGLGINLA
TADTVIIFDS DWNPQNDLQA QARAHRIGQK NQVNIYRLVT ARSVEEQIVE RAKQKMVLDH
LVIQRMDTTG RTVLDRGSSG PSNHTPFNKD DLSAILKFGA EELFKDEQEN DEELVCDIDE
ILRRAETRNE DPEMPGDDLL SAFKVASIAA FEEEPDAATK ENEANSQAAD EDDTKDWDDI
IPENFRKIVE NEEKSKEMED LYLPPRRKTT ANQGDKKSKK GQADDSNDSD YDGGSDGSND
ADGKSKRRGR PAMKEKIVGF NDAELRRFIR SYKKFPAPLE RLEAIACDAE LQEKPLAELK
RIGQMLHDRC VQFLEEHKDD VPPAAPAKKP PNDPNAAPED AAAAKQKRSR ATYSVKLGGV
SFNAKTLLSC EEELKPLNSV IPATINERLA WSLDVKTRPA NFDVEWGVIE DSKLLCGIYQ
YGIGSWEQMK MDPSLNLTEK ILHNDDRKPQ AKHLQSRAEY LLKIIKKNLE TKKKGAETKK
RKPRKQKEPK TAAAVGSAAA HSATPERKSR NVSEGDELSQ TGADSTPAPT EKKTRKERKE
SSTKATVDPV DEAASNDVDA SNTSATTATA KKKNKTSSKE KDGTPKSSAK SKKSATSDST
NKPMHFTANN EPRALEVLGD LDPNIFNECK EKMRPVKKAL KALDRPDTSL SSQEQIKNTR
ESLMAIGKQI DVCLEAYSKD SEKKEWRSNL WYFVSKFTEF DAKKLFKMYK QMLKTSEGEA
KQKSPPVAKA KSNSASPQKR PKDDSLNQNG SDEKNKSAAK KKKKDKEKEK EKDVEKVKDK
TRDTPKSDRF TKIGNANKPP AAGGAAMHMN KNKRPQQAGG VNNSPMKRKR EDNESGAVGG
IPNAAGGSDL KSMSFKRLNM DEQGRNRDDR KNRHRDDYYG SGNSHDGLNT SRGSIGSGNG
DRHSSMNSPS TPNNRMHPSN SRLLPGNNPS PYGDSNSGGG GGGDRWGHNR DRYGGGNNDY
NKRERYDGYN NRPGGYHRDH KDRDRDRRFD KRRYPPSHPP QHGYGNHYMG PNYYMPPNGG
VPPGMGGGPH GGYSGAGRGG DPRYNHPAEW PREYPPDSYR RGAGGGPSGA VGGGGGQSGP
PIPSSNSGDR RPPLPPTSQT
//
