ID   A0A1I8PG27_STOCA        Unreviewed;       977 AA.
AC   A0A1I8PG27;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE            EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN   Name=106089398 {ECO:0000313|EnsemblMetazoa:SCAU007723-PB};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU007723-PB, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU007723-PB}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU007723-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001837};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004325}.
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DR   RefSeq; XP_013110688.1; XM_013255234.1.
DR   AlphaFoldDB; A0A1I8PG27; -.
DR   EnsemblMetazoa; SCAU007723-RB; SCAU007723-PB; SCAU007723.
DR   GeneID; 106089398; -.
DR   VEuPathDB; VectorBase:SCAU007723; -.
DR   OrthoDB; 48011at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR045817; OPA1_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF19434; OPA1_C; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          301..577
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   REGION          38..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          216..268
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          913..972
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        38..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   977 AA;  112656 MW;  17E2494E83DC74BA CRC64;
     MLRVTKHIAQ RDATKRVTYL CHKIVVSSNS NYSTLNHRFG GGSYHRQQQH GSNGQGSGGQ
     HFRSDFLAPH GPKAWTIPPN RGYGMVVVRI LRGALKLRYL LLGGAIGGGM TLNKKYEDWK
     DGLPDLKWLE EALPQGEKWS QFSKTLMEIG GAVKDVIEID PRLKQLGEDK VNEWRQWFDN
     RLDDAIEAAD YQGVAIVESK DDIKSKTTVA ALSLSQDESR KKYDNLQSQV ETLQTEIMNV
     QIKYQKELEK MEKENRELRQ QFLILKQNKK TSTKKIKKSL IDMYSEVLDE LSGYDTSYSM
     ADHLPRVVVV GDQSSGKTSV LESIAKARIF PRGSGEMMTR APVKVTLAEG PYHVAQFRDS
     DREYDLTKES DLSELRREVE FRMRASVRGG KTVSNEVISM TVKGPGLQRM VLVDLPGIIS
     TMTVDMASDT KDSIHQMTKH YMSNPNAIIL CIQDGSVDAE RSNVTDLVMQ CDPLGRRTIF
     VLTKVDLAEE LADPDRIRKI LSGKLFPMKA LGYYAVVTGR GRKDDSIDAI RQYEEDFFKN
     SKLFQRRGVI MPHQVTSRNL SLAVSDRFWK MVRETIEQQA DAFKATRFNL ETEWKNNFPR
     LRESGRDELF DKAKGEILDE VVTLSQISAK KWEEALNDSL WDKLSNYVFE NIYLPAAQSG
     SQNSFNTMVD IKLRQWAEQA LPAKSVEAGW ETLQKEFIAL MEKAKKSPDH DNIFDNLKAA
     VVDESIRRHT WEDKAIDMLR VIQLNTLEDR FVHDKSEWDQ AVKFLETSVK AKLAQTEETL
     NEMFGPGQFT RLTHWKSLTE DQNKRRHVKT ELDKILRNDD KHIPTLSYDE LTTVRKNLQR
     ENIEVDTDYI RQTWFPVYRR HFLKQALHRA SDCRKAYYLY SQQGAECDIN CNDVVLFWRI
     QQVIRVTANA LRQQVINREA RRLDKEIKEV LDEFSEDEEK KSHLLTGKRV TLAEELIKVR
     QIQEKLEEFI NSLNQEK
//