ID A0A1I8PH01_STOCA Unreviewed; 2001 AA.
AC A0A1I8PH01;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Dedicator of cytokinesis protein 1 {ECO:0008006|Google:ProtNLM};
GN Name=106080540 {ECO:0000313|EnsemblMetazoa:SCAU007952-PB};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU007952-PB, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU007952-PB}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU007952-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_013097395.1; XM_013241941.1.
DR STRING; 35570.A0A1I8PH01; -.
DR EnsemblMetazoa; SCAU007952-RB; SCAU007952-PB; SCAU007952.
DR GeneID; 106080540; -.
DR KEGG; scac:106080540; -.
DR VEuPathDB; VectorBase:SCAU007952; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11697; DHR2_DOCK_A; 1.
DR CDD; cd11872; SH3_DOCK_AB; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 438..618
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1284..1696
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1717..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1977..2001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1717..1769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1840..1862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1865..1904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2001 AA; 229850 MW; C1338FA0AA243C3C CRC64;
MTVWNSNPKQ VFGIAKCNFD QDDKPHRLSL DVGDSVVILK ETTHWYYGYK QRNKEQRGIF
PKSYIHLCDY KIVNGEYCIQ RTEIVEEITK VLLEWGIILK QYFLVRHPDF HSIRSKMNSL
NNNRALLISG NLPLDEIRTI KLTATSQIDT GNNLLGLDMV VRDESGDILD TNTICTTELY
EHHMNAVNRI IKANRPQTIH HGPKPYKNFS HNILLHVNAF VCKFQEDSDL IFTLFDGESH
RPISENYVVK WSRTGIARDI DQFDNNRVLF TDLSKNDVSI PKMYLVCYVV RIGSMEMKEN
DSKRTSITNT MLTAASKKNS QLSISSSGSF SGTEYIMRRP FGVAYKDLTP IINKPDEFKG
NLDMPFILCE KDNMDITLRK LIANKDIGKI DSRMCVTVEV LQGDIKQIKE DFPRLLHTNV
PIARKMGFPE VILPGDVRND LYLTLCSGEF ARIAKTSEKN VEVTVTVCNE HGHTVPGMMS
IGAGLAPIDE YKSVVYYHDD KPKWMETFKI HVPIDEFKQC HLKFVFKHRS SNEQKDKSEK
PFGLAYMKLM QDNGTTITQG QHTLAVYKID HKKLDKTNSN NTYLELPATV NELQGTKPST
AGLTLLPKDQ LVIGVNLCST KLTQSVSLLG LLNWSAHRET LEESLNALSN VPGEEVVKFL
QDILDALFNI LVENDSPEKY DQLVFMSIIH LIETVSDLKY QHFLTVLDVY INESFSATLA
YAKLIDVLQR NVEEAIEPKE KSVDGIEIDE RIEVKRLYKT TRYLHYVMKF IIRSRILFSA
INGNSDYDDF ANKLHELLEM FIKMIACPTD LLKSEGALLK NLHIIATDLM QVFDPVRLSI
VIVNILKQFP PRRLTQSKMG CIKDFVDSKL FHLPECRAIL LPVFCNHIKD RLESKEEGDT
KSDIWQQEKN LSKAAKVLGQ LKSQLHTRET TAKQKVTECI NIMNNILKLL YRKDIGHTHN
DIRDIMLILL RTVIKTSQAL DRENQLVGNL VAIMLGILQC MDSVHYEIYV KHLNNRFELQ
DFVIEILLVF EELVSPHQKP VFPRDWMDMI MHQNTVILGS LKQLSIVIVD HFIDPFEKQV
WSNFFQCSIA FLIQSPLQLN DFNDNKRQVI FARYRDIRKD TAQEIRKMWF QLGEHKPKFV
PQLVEPALEM SMIPEIELRK ATIPIFFDMM QCEYYSSKLI HDSYGDTKRN NAHYKANFNE
FETEMIEKLD ILIGAGKGDV QYKELFEQIL LEKCQAHNIL NVEGTKFVNM VSKLMDRLLE
YRCIIQDESK ENRMACTFSL LQFYSEVNRK EMYIRYVYKL CDLQMEFDNY TEAAYTLKLH
TELLSWNDTE LSPQLRSHRH IQCRTHRDLK EALYYEIIDY FDKGKMWECA IDMCKVLAQQ
YENEIFDYIK LAELFKKMAL FFEKILKEMR HTSEYFRVCF YGLGFPRFLQ NKMFIFRGKE
YERLSDFSTR ILVQHPQAEL MHTLEMPGED ITQGEGQYIQ VNKVEPIMDE AFAKFNDKII
SNEIVKYFAN NNVQKFKFSR PYRESTIGDA DGVGNLWLER TVVTIKFPLP GILRWFPVID
SDTFKISPLE LAVETMKSTN KDIRNLIIAH KNDETLPVNQ LSMKINGIVD PAVMGGSGKY
EDAFLTTEYL EEHPDDKDLV DELKDLIAAQ IPLLDIAIAL HKQKAPESLK LFHERMETCF
ADMQANIESK YGKRTCDLKL DRDSVIMRRN NSFLPTMFDN SNRLSETSMG SSDSGLSKST
SSMRPQTNSI KSTFGFTFNP RPTLGHSPST KSKTKDKTPS KRRSIKKLDR DTLSLPVANS
QWYTTPLTTI TSTPERDSNT SIISASNTSL CSKTADPKVL TEELTSKRPL RSEKEKERRL
SRPASIATPT ASMKGFSAAD THSLSGADSS NRNSVDTTDS TSEEDLIPPP LPAKTRDSTD
FSSLNYTLDW NSNSFSLGGA LSPNGTITRT TSCSTSTSIV NTSYEYVETK NFIITSALAN
DDKKRPPTPP PKPSRNSKHI P
//
