ID   A0A1I8PRQ3_STOCA        Unreviewed;       844 AA.
AC   A0A1I8PRQ3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   Name=106091975 {ECO:0000313|EnsemblMetazoa:SCAU010464-PA};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU010464-PA, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU010464-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU010464-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|ARBA:ARBA00008785, ECO:0000256|RuleBase:RU003426}.
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DR   RefSeq; XP_013114155.1; XM_013258701.1.
DR   AlphaFoldDB; A0A1I8PRQ3; -.
DR   EnsemblMetazoa; SCAU010464-RA; SCAU010464-PA; SCAU010464.
DR   KEGG; scac:106091975; -.
DR   VEuPathDB; VectorBase:SCAU010464; -.
DR   OrthoDB; 1069499at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23406:SF80; GH17657P-RELATED; 1.
DR   PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426}.
FT   DOMAIN          359..540
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          550..803
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
FT   REGION          180..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          328..362
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   844 AA;  93537 MW;  350EAAEAF96E94CC CRC64;
     MQSKVLQPFF ISARLLRCSH RSPVYPSAVN SFSPSHGQRT PNEQQFYKTT IPINEQCQHQ
     QCPYSGNGVI RSATADGKDL TAVAVQNAIH GSYDVTPHTT TQHGISSTMS PLATETQQCV
     CTGMRNGPTN ENHTTAATTT TTIEYELANG YAKLSKISTS RVVAEQPSNV VAATVVAVPK
     SESSSPSRIQ TEAGKESTET TNSKLPLLSQ EDLDDLMRNV NAINTVNRTL RQSFNQQQPN
     HHQTPLYNLQ QRSNFHMNFS SMNGSSDSPM KKVPRDRLGL WGTGGEVDVP GNISGLQRLQ
     QKKYNKGLAF NLEERQLLGI QGLLPARIKT EEEQVEHSLL LLDRLENDLD KYMYLNNLAE
     RNERLFYKVL SSDVAKMMPL VYTPTVGLAC QKFSLIFQYP KGMYITINDK GHVYEVLRNW
     PETDVRAIVV TDGERILGLG DLGANGMGIP VGKLSLYTAL AGIKPNQCLP ITLDVGTNTE
     SILADPLYIG LRQKRVTGRD YDEFIDEFMH AVVRRFGQNC LIQFEDFANA NAFRLLEKYR
     NDFCTFNDDI QGTASVAVGG LLASLKIKNT QLRENKILFF GAGEAALGIA NLCLMALMKE
     GLSEAEAKER IWMVDSKGLI VKNRPAGGLT EHKLHFAQDH APINTLPEAV EALQPSVLIG
     AAAIGGAFTK EILQRMAEFN EMPIIFALSN PTSKAECTAE EAYKYTNGKC IFASGSPFDP
     VEYNGKTFYP GQGNNSYIFP GVALGVLCAG MLTIPEEVFL MSAERLADLC EPEDLERGSL
     YPPLKRITEC SVEIAAYIME YAYKNGLATV RPEPEDKREF IKSQMYNLQY SSSLPEVYCW
     DHKL
//