ID A0A1I8PRQ3_STOCA Unreviewed; 844 AA.
AC A0A1I8PRQ3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN Name=106091975 {ECO:0000313|EnsemblMetazoa:SCAU010464-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU010464-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU010464-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU010464-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785, ECO:0000256|RuleBase:RU003426}.
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DR RefSeq; XP_013114155.1; XM_013258701.1.
DR AlphaFoldDB; A0A1I8PRQ3; -.
DR EnsemblMetazoa; SCAU010464-RA; SCAU010464-PA; SCAU010464.
DR KEGG; scac:106091975; -.
DR VEuPathDB; VectorBase:SCAU010464; -.
DR OrthoDB; 1069499at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR015884; Malic_enzyme_CS.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406:SF80; GH17657P-RELATED; 1.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00331; MALIC_ENZYMES; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003426};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003426}.
FT DOMAIN 359..540
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 550..803
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 180..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 328..362
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 844 AA; 93537 MW; 350EAAEAF96E94CC CRC64;
MQSKVLQPFF ISARLLRCSH RSPVYPSAVN SFSPSHGQRT PNEQQFYKTT IPINEQCQHQ
QCPYSGNGVI RSATADGKDL TAVAVQNAIH GSYDVTPHTT TQHGISSTMS PLATETQQCV
CTGMRNGPTN ENHTTAATTT TTIEYELANG YAKLSKISTS RVVAEQPSNV VAATVVAVPK
SESSSPSRIQ TEAGKESTET TNSKLPLLSQ EDLDDLMRNV NAINTVNRTL RQSFNQQQPN
HHQTPLYNLQ QRSNFHMNFS SMNGSSDSPM KKVPRDRLGL WGTGGEVDVP GNISGLQRLQ
QKKYNKGLAF NLEERQLLGI QGLLPARIKT EEEQVEHSLL LLDRLENDLD KYMYLNNLAE
RNERLFYKVL SSDVAKMMPL VYTPTVGLAC QKFSLIFQYP KGMYITINDK GHVYEVLRNW
PETDVRAIVV TDGERILGLG DLGANGMGIP VGKLSLYTAL AGIKPNQCLP ITLDVGTNTE
SILADPLYIG LRQKRVTGRD YDEFIDEFMH AVVRRFGQNC LIQFEDFANA NAFRLLEKYR
NDFCTFNDDI QGTASVAVGG LLASLKIKNT QLRENKILFF GAGEAALGIA NLCLMALMKE
GLSEAEAKER IWMVDSKGLI VKNRPAGGLT EHKLHFAQDH APINTLPEAV EALQPSVLIG
AAAIGGAFTK EILQRMAEFN EMPIIFALSN PTSKAECTAE EAYKYTNGKC IFASGSPFDP
VEYNGKTFYP GQGNNSYIFP GVALGVLCAG MLTIPEEVFL MSAERLADLC EPEDLERGSL
YPPLKRITEC SVEIAAYIME YAYKNGLATV RPEPEDKREF IKSQMYNLQY SSSLPEVYCW
DHKL
//