ID A0A1I8PRX9_STOCA Unreviewed; 714 AA.
AC A0A1I8PRX9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN Name=106086136 {ECO:0000313|EnsemblMetazoa:SCAU010516-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU010516-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU010516-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU010516-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR RefSeq; XP_013106132.1; XM_013250678.1.
DR AlphaFoldDB; A0A1I8PRX9; -.
DR STRING; 35570.A0A1I8PRX9; -.
DR EnsemblMetazoa; SCAU010516-RA; SCAU010516-PA; SCAU010516.
DR GeneID; 106086136; -.
DR KEGG; scac:106086136; -.
DR VEuPathDB; VectorBase:SCAU010516; -.
DR OrthoDB; 1356373at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF504; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 500..629
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 80311 MW; EB3A99E3513C7597 CRC64;
MLNGVPGDSA TTFPALTPTI NGSKKPNKPV LTKTKSKRPR KEHVSKDEIP TSCPALQVAE
QSTTIAVVRA PSTQQLQFDK MSVHSVSSED ISTSNGGKCC SAAARNPAIK TGRRIQLMQM
IILPFIPILA LIVQTSISLH DVLEYRVEVA DIETQVTIAT DLGKVVTHLQ LERSEVAFYI
FTNGSKVRSN LTQRFAVTDQ ALNNMTTWSE VSVPTSPDDD DYEVLLNRTE FQSRLNEFRD
RIRAEPEDNS ITDVMNWYTS INKALLHHLS EQIKEADNSG VWRYLVGFKN LLKSIECQNI
ASSFGIKYYG RGSLGSDGFV NFIRYEFLAR EFINSTLNYV PSLREMYVNI TRTEKYKKMK
RMSSVVLKNH RRNGSDEQSA IEYYDSMHNY TDDLRILQKD LRLQIKAYVG ETLKAAAKNE
AIGISILIVV LCVSPIIIIL VKNAAATIQV YALNLAEKAK ELKREKRKSD SLLFQMLPPS
VAMQLKHTQQ VPAELYESVT VYFSDIVGFT EIAARCTPLE VVTFLNSIYR VFDERIECYD
VYKVETIGDS YMVASGLPVK NGNKHITEIA TMALDLLDAS SCFKIPRSME ILQIRCGVHT
GPVVAGIVGT KMPRYCLFGD TVNTASRMES TGEAHKVHIT EEMNQALMRV GGFRTEHRGL
IDVKGKGLMS TYWLTCKDGP VKVREEIAWF ADIQPVFLEN LKLDPSYKQK KQKK
//
