ID A0A1I8PV29_STOCA Unreviewed; 745 AA.
AC A0A1I8PV29;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=106096271 {ECO:0000313|EnsemblMetazoa:SCAU011387-PG};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU011387-PG, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU011387-PG}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU011387-PG};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR RefSeq; XP_013119408.1; XM_013263954.1.
DR AlphaFoldDB; A0A1I8PV29; -.
DR EnsemblMetazoa; SCAU011387-RG; SCAU011387-PG; SCAU011387.
DR GeneID; 106096271; -.
DR VEuPathDB; VectorBase:SCAU011387; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09919; SH2_STAT_family; 1.
DR CDD; cd14801; STAT_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 595..712
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 745 AA; 84745 MW; A8D77CAC15089BC7 CRC64;
MNLWKRISCN PDVKQSMIQY YDEKGLADIR VYLAPWIEER IMSELINTTS TELYERDALQ
FYEDLKQKLI PLSNDNLIKF KLAEICTSIT QTPAVELYTH FRTGVQREIQ LLDQMPQFAY
GVAAAVNGSA VGTPGIIGGA SMPVPTGMHS NNMAAATLNG SNSYAGDNLF AVQSTIPKLS
MAINTIYSEV QQFGRSYETF HNCFNNYSQR KAAMVGHDSE LHLQDIQLQD QCRILAGQRS
SILQELKRIT FDYDAIQETV INELKNWQRN QALAGNGAPF RDNLDDIQRC IVLLLELVGK
ILENVNAMQR IPLEHNDECG ELIVHVRQAQ QVLVLSSFIV EKQPPQVMKT NTRFAAGVRW
LIGPQLGISV NGPQVECIIL SEAQAQRHSA QRTMPDSSNS TPASSGEIVN NIGNLEYNNQ
TGVFSASFRT MQLKKIKRAE KKGTESVMDE KFALLFYTSV VVNDYRIRVW TLSLPVVVIV
HGNQEPQSWA TITWDNAFSD IVREPFHVPD KVVWSQLAMA LNIKFESSTG RGLTEENLNF
LHEKLFRRSL VNNGDEDYIT WAQFCKEPLP DRSFTFWDWF FAIMKLTKDH LLNLWKAGLI
VGFINKHRAE QELMHTQEAG TFLLRFSDSE LGGITVGFLK DNSVLMLSPW TARDLNIRGL
ADRIHDVDML RWLYPSRRNR DEAFNEFYTQ RMEESTRHDG YVTNTIRVNV PAIENNTGTP
QHVMQSPHSH DIQMGNLQNS TIMHL
//
