ID   A0A1I8PV47_STOCA        Unreviewed;      1335 AA.
AC   A0A1I8PV47;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SCAU011395-PA};
GN   Name=106086848 {ECO:0000313|EnsemblMetazoa:SCAU011395-PA};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU011395-PA, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU011395-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU011395-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013107112.1; XM_013251658.1.
DR   STRING; 35570.A0A1I8PV47; -.
DR   EnsemblMetazoa; SCAU011395-RA; SCAU011395-PA; SCAU011395.
DR   GeneID; 106086848; -.
DR   KEGG; scac:106086848; -.
DR   VEuPathDB; VectorBase:SCAU011395; -.
DR   OrthoDB; 3600886at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.2950; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1335
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009327370"
FT   DOMAIN          430..564
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          636..726
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1241..1331
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   1335 AA;  151862 MW;  196173DB12DF55D4 CRC64;
     MRRFWIFIVA LTMQQSKASL TASGEGFYSI VAPGTLKSNR KYTVAITLHE NPQPATIRVS
     IEGPRYNESK QVTVAPLETQ ELHFMPPKLH YEKYNLYAEG LNGLKFRNET SLNVDDSAGP
     KIYTQTDKAR YKPLDLVRFR VVILDEHTRP LNISEPMRVD ILDCNENRVK QFKDIVLIHG
     VYTDNFNLSE FPAMGPWQIV VTISGKYGYS KRKFFTVEKY KLPKFYVEID TPKDLTPANR
     ELQIMFFGKY TFNKYVEGNA TVSLFKEEFY ESHFLLKKQL AVKETAIVNI KTEDIPNYHT
     IEKLSLRIQL TDKFSGDTKG KTEFINIHPE TYQISVNPAD IEFNGRIPYR LKAYVREWNG
     MAVMDSKTPV HMKHGDRIYE AHLDKEGSAT FEFKHEPLSD HIIKYKDSSA SLPNILGDNK
     SQDKEKDSFC RLTLLNGSPT LGKMLEIEVT SSKDIPYIVY TIIGHANIVR MGLIKSTTKT
     KSQIIRLMPT IEMVPRSFVY VHYVHRGNYR YEEMTLEFPN EFENKIAVTA PHQVKPGQEV
     TLNIKALPKS YACILAVDLG VYLLDSSYDI SRSIIFSDLL RDRTQSPVQS TKYPGIVSGT
     LTLTNAHYPF TVLKDILYPS GEGALGLDAR KRFPETWIFQ NLEISEENTK VTLNIPDTIT
     TWRITTFSVH NDKGFGMAED ATNIVTTLPF FIDVNLPYAV KRGEIVAIPM TLFNYHNMSL
     EAKVTMYNGE QEFDFMDVEM SATADVRLRS KNITISPNGG QSLSFTIRPR KLGEISLNIT
     ANSNLSSDAV LHKLKVEPEG IKENDNQPLL VSIPVNEAVA STINAEIPNN IVAETEFITL
     SMTGDALAPI LENLDGLVLM PTGCGEQNMV NFAPNVLVLL YLKAIGKYGQ ERELVKRAKN
     YIEIGYQQEL SFRHTNGCYS VFGEKRDRDE GSTWLTAYVI RFFIKASAFT SIEQRIISSG
     LDYLAENQRP NGEFTFTGYL FYPAQQNRFG FTAFVLMTFL EDRRHSQKYK SVIEKGLNFL
     SENLNDINDI YALSIMAATL KMAKHKDSTK IIEKLMEKIN EKDGLRWWSA NDKSSEKDVE
     ITSYVLIALL ETPGNYGPII KWLLGQRNSQ GGFMSTHDTV VGLQALVKYY KSNTHKSPGI
     KLQYVAEDDK GITMKTDEFA IDSESNIGIQ THILPRSTRF VKFNATGSGQ SLLQLSSHYY
     KASDEDTQHF QIKTSSERVN ENTIDLDICF SYQQSDGSAF TNMVIMEVNL PSGFRTDAEF
     SYNLLENELI QRIQAQKDDT ILVIYFDNLA ANKQNCITVS ADKTHDVSLR KPSAIRMYDY
     YNISRSNTEF YSIDD
//