ID A0A1I8PXX3_STOCA Unreviewed; 510 AA.
AC A0A1I8PXX3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN Name=inx {ECO:0000256|RuleBase:RU010713};
GN Synonyms=106081870 {ECO:0000313|EnsemblMetazoa:SCAU012094-PE};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU012094-PE, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU012094-PE}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU012094-PE};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Structural component of the gap junctions.
CC {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC ECO:0000256|RuleBase:RU010713}.
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DR RefSeq; XP_013099575.1; XM_013244121.1.
DR AlphaFoldDB; A0A1I8PXX3; -.
DR EnsemblMetazoa; SCAU012094-RE; SCAU012094-PE; SCAU012094.
DR VEuPathDB; VectorBase:SCAU012094; -.
DR OrthoDB; 2873211at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; INNEXIN; 1.
DR PANTHER; PTHR11893:SF40; INNEXIN SHAKING-B; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 247..264
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 317..336
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 406..433
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT REGION 74..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 59455 MW; 2E173FAC74F29847 CRC64;
MYKQEPFSRR GSLRSLRSAP LLSTVLESTL SLTRIHPIAS LELPGLDYAI QSQSAIIHER
RELGTSLRGI ATITAGSTVP PPQTRLGPQA SVRETKRSKQ PQRALSRKLK PHLVADTVKQ
YISRAQRPAK GSQEQQPNME FLRGVYAFMQ VSHVKIDSPV FRLHTNATVI LLITFSIAVT
TRQYVGNPID CVHTRDIPED VLNTYCWIHS TYTVVDAFMK KQGSEVPFPG VHNSQGRGPL
TIKHTKYYQW VAFTLFFQAI LFYTPRWLWK SWEGGKIHAL IMDLDIGICS EAEKKQKKKL
LLDYLWENLR YHNWWAYRYY VCELLALINV IGQMFLMNRF FDGEFMTFGL DVIQYMEADQ
EDRMDPMIYI FPRMTKCTFF KYGSSGEVEK HDAICILPLN VVNEKIYIFL WFWFILLTLL
TLLTIIYRVV IIFSPRMRVY LFRMRFRLVR RDAIEIIVRR SKMGDWFLLY LLGENIDTVI
FRDVVQDLAN RLGHNQHHRV PGLKGEIQDA
//
