ID A0A1I8PYM3_STOCA Unreviewed; 402 AA.
AC A0A1I8PYM3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Sulfotransferase domain-containing protein {ECO:0000259|Pfam:PF00685};
GN Name=106088520 {ECO:0000313|EnsemblMetazoa:SCAU012281-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU012281-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU012281-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU012281-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013109535.1; XM_013254081.1.
DR AlphaFoldDB; A0A1I8PYM3; -.
DR STRING; 35570.A0A1I8PYM3; -.
DR EnsemblMetazoa; SCAU012281-RA; SCAU012281-PA; SCAU012281.
DR GeneID; 106088520; -.
DR KEGG; scac:106088520; -.
DR VEuPathDB; VectorBase:SCAU012281; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF73; HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..385
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 159
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 159..163
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 240
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 248
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 365..369
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 348..360
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 402 AA; 46237 MW; 263665443678743F CRC64;
MFIHWFNNLS NRSLVITILI CISLIYVSYT FNSCLITSLG RTFNRNPLKQ FFISTSLWPQ
TSEEANANAT TAAFNNSTTN FTSSYNITKN SVQQQQLLRD EIHKKLSPSH IASNGSVSSS
SSSSLPHILD GSPKYRLLRQ QGSRPSRHLP DTLIIGVKKS GTRALLEFIR LHPDVRAAGC
EVHFFDRHYQ KGLHWYRHHM PYTIEGQITM EKTPSYFVTK EVPQRVHHMN ANTKLLVVVR
DPVTRAISDY TQAASKKTDM KRFEDLAFVN GSYAVVDTNW GPVKIGVYAR YLEKWLHYFP
LSQLLFISGE RLIMDPAYEI GRVQDFLGLK RVVTEKHFYF NATKGFPCLF KSEARSTPHC
LGKTKGRNHP HIETAAIERL RDFYRPFNNK FYEMTGINFA WP
//
