ID   A0A1I8PZI0_STOCA        Unreviewed;      1322 AA.
AC   A0A1I8PZI0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   28-JUN-2023, entry version 29.
DE   RecName: Full=phosphatidylinositol-3,4-bisphosphate 4-phosphatase {ECO:0000256|ARBA:ARBA00013037};
DE            EC=3.1.3.66 {ECO:0000256|ARBA:ARBA00013037};
GN   Name=106082697 {ECO:0000313|EnsemblMetazoa:SCAU012466-PB};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU012466-PB, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU012466-PB}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU012466-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- PATHWAY: Signal transduction; phosphatidylinositol signaling pathway.
CC       {ECO:0000256|ARBA:ARBA00004847}.
CC   -!- SIMILARITY: Belongs to the inositol 3,4-bisphosphate 4-phosphatase
CC       family. {ECO:0000256|ARBA:ARBA00006306}.
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DR   RefSeq; XP_013100820.1; XM_013245366.1.
DR   STRING; 35570.A0A1I8PZI0; -.
DR   EnsemblMetazoa; SCAU012466-RB; SCAU012466-PB; SCAU012466.
DR   GeneID; 106082697; -.
DR   KEGG; scac:106082697; -.
DR   VEuPathDB; VectorBase:SCAU012466; -.
DR   OrthoDB; 5490552at2759; -.
DR   UniPathway; UPA00944; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0016316; F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd13272; PH_INPP4A_INPP4B; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039034; INPP4.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12187; AGAP000124-PA; 1.
DR   PANTHER; PTHR12187:SF11; PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
FT   DOMAIN          28..122
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          168..296
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          316..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          883..908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1322 AA;  149363 MW;  EAB6339295AB86CC CRC64;
     MRFNKAELST LASNPTTKFE KQGLLIITER QEGFFRKTDV NYPRWCKLRG NLLFYLKDHD
     PNSQPVGVLV LENCRPLIRN EEREFDGYVF ILEFEGSLPQ RISTHTAQER LDWVKSIQLA
     SYAYLNRQIQ YLEDQITLAM GNRIEKGLPL YTPANDATLM AGLLDLNVAS NVKAVTKVEE
     DLSEIPLCES ALSCDNLPCA DNGRLPCPRV ICGVLVPGED IIWHDYARTE IIENTKSPQF
     LCTLTFKQSD GFTADTPLRF TVYDVREKVS QTSVPLGYAE VVLGAIQDAT RFRLPLRSVH
     GDCGFINIAS WAPDTDKQLQ PPPRSTTQVF EQQSKGHRRT QSLPPKLGVK LFVPFQGSIQ
     RVFANPRIHT YRLNSSLGAD ISVHETMLES KLCFNIPQQL LSIWILREKE LLQEISGMGE
     LGGDWRRRQM DLLDKHLKLL KDYSQAKQNL QQITKEEGPF FKRSSVKTDE SLEFIPVNLH
     LQRMWVQNDS LNRSAVLDIV TVGAFTRHGG LKKKTGGLIK LLQDTKESPT KFEASNNCKV
     LASNDAVQAI KHLRKEIVEI MSQLLTLAKT KNPKGMMPLC NEMVTKTKTL LNIWEPSLVE
     EAFSFIEQHR IIEEPDNVLM PMSPFRKITQ QLNDLDLKSP ELEDFATPIV APPDLWPRVK
     TPTGHHNRLI RSNSLTQLRT SPSLTLDIDA IHNLQHTVRA YNEHLQSKAR QQKQSQLTPE
     IDDEMEATYQ SLPAYVLPDS NFGKPYFNER DEDEDDDPMT STIKLIDLDE SLTVSQTLQL
     PTITATVAKP INASCRTSLP SNCNEYEAMK CSILASHNAR FLDTKMMSTS PSANYYRPTE
     EPEPLDLTQL NIEASVMCLV SKIKFLCGRC GSPAIRLRNP KGSMKRSGFS NAPVPDVVDN
     GNSESTTSYA CDEPKHVEGL EGSSPNGNSN GLNLDLTQPA LENVAAKKGN KFTDGLDLSL
     TTDWASELRP SMRKLRHAMD GLLKTARLMH SVQRLQQDMH RISINLETMY RRDVCFSQSL
     TALVTALMAK LWGNEITDNF IRILCDLGPL AYFEGLLSLQ GSEIDMWGDM CIAIEDLLGV
     DFELVRSNNG SHDSQSVPTP RITGSRQSLT VYLPVPEHVY AMLPTKHAVS FKVTPIFFNI
     GINEKATLAE AMGRTREQHR SNWDNYVRLK QYYTRFRKLP LTMPETPSKH EPHMPAPQML
     LNILNFLEDQ LKANVSKNVK ILHLVEDACR LMSGLRFTSC KSAKDRTGMA VTLEQCRVLE
     QEFQLPAKNV PQILNTMRSE GCRMDNVFKS IDKRKYAFNL PQVLSLPAMY RPPVGSYGKA
     ET
//