ID A0A1I8Q4P2_STOCA Unreviewed; 865 AA.
AC A0A1I8Q4P2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=106080426 {ECO:0000313|EnsemblMetazoa:SCAU013889-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU013889-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU013889-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU013889-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR RefSeq; XP_013097267.1; XM_013241813.1.
DR AlphaFoldDB; A0A1I8Q4P2; -.
DR STRING; 35570.A0A1I8Q4P2; -.
DR EnsemblMetazoa; SCAU013889-RA; SCAU013889-PA; SCAU013889.
DR GeneID; 106080426; -.
DR KEGG; scac:106080426; -.
DR VEuPathDB; VectorBase:SCAU013889; -.
DR OrthoDB; 1089019at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 197..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 254..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 305..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 366..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 401..426
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 446..469
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 490..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 590..612
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 624..647
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 708..772
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 816..865
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 96541 MW; 4B8DFD999B3511BC CRC64;
MKRQKEDKKY LVDLEENSQT STDEYPEKIF KPIDDDMEDE ELVTKQGIRE PPTTVMNAGS
KQLDTHQNNR TVNIENRLDA VPAGRSVPLS NSGAPTKQQA SAAMLSIPSG SQQSQQQAPA
AISNIHSGSQ QQQPPSRPRG QQNPTFRLRS RTSAINESLA NKRDIYESLD YDVCENVLFQ
KEQERIISTR FSLRKDVLRW IIFIQIGIIT ALIACAIDIV IEELSARKYE FLKHSVDANV
PHADNPTGDL VLPYLYWLGL SMAPVAIGAA MVTYLEPITA GSGIPQVKCY LNGVKVPRIV
RIKTLAVKSI GVITSVVGGL AGGKEGPMIH AGAVVAAGIS QGKSTTFIKD FRIFKAFRDD
HEKRDFVLGG AAAGVSAAFG SPIGGMLFSL EEAASFWNQN LIWRTLVASI ISSFTLNIVL
SAYHGLSNFT FTGLFNLGKF EQPLAFDYYE LPIFMAFGVT GGIFGALWNM FNTKINKFRS
RFIKYKFAKV MEAVLVAMIG VSLACIMIYL INDCRPLGND PTDYPTQLFC EDNEYNAVAA
LWFQTPEATV RSLFHDPPGS HKILTLAVFT LIYYLLSCFT FGLNVSLGVF IPTALVGAAW
GRLVAMVAFY MFPDAVFLNP GKYALIGAAA NLGGVLRMTI SLTVILMETT GIETSFFFPL
IITLISAKWV GDYFNEGIYD IQVKINHVPM LPWEPLPHYM GLKASNIMSS PVVCIKLIDK
SKYIFDILHR YQHNGFPVVE DVEGNDRSSG RVCGIILRSQ LIVILLKSLY EEKKRFWFNE
TSIQTFRDVY PRYPSIDNVR LHGDKENYTV NLDIFMNPSP VCSREHDSVQ KIFNKFRALG
LRHLIVVNRE NRVAGIITRK DFLHK
//
