ID A0A1I8Q6L9_STOCA Unreviewed; 2045 AA.
AC A0A1I8Q6L9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Down syndrome cell adhesion molecule {ECO:0008006|Google:ProtNLM};
GN Name=106095735 {ECO:0000313|EnsemblMetazoa:SCAU014367-PC};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU014367-PC, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU014367-PC}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU014367-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013118501.1; XM_013263047.1.
DR EnsemblMetazoa; SCAU014367-RC; SCAU014367-PC; SCAU014367.
DR VEuPathDB; VectorBase:SCAU014367; -.
DR OrthoDB; 4503820at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd20957; IgC2_3_Dscam; 1.
DR CDD; cd20955; IgI_1_Dscam; 1.
DR CDD; cd20953; IgI_2_Dscam; 1.
DR CDD; cd20956; IgI_4_Dscam; 1.
DR CDD; cd20958; IgI_5_Dscam; 1.
DR CDD; cd20954; IgI_7_Dscam; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR021012; Dscam_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF109; FASCICLIN-2; 1.
DR Pfam; PF12355; Dscam_C; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 10.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 10.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..2045
FT /note="Down syndrome cell adhesion molecule"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009327792"
FT TRANSMEM 1634..1656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 143..235
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..344
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 348..427
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 434..528
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 533..619
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 624..719
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 724..816
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 821..913
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 922..1016
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1021..1125
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1126..1222
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1226..1319
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1321..1403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1411..1504
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1508..1603
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1806..1867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1883..2045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1830..1857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..2023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2024..2038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2045 AA; 226285 MW; E1E1F0D2BF44524E CRC64;
MLQPSAMGLL RSLIKWLSLL AVVTAYSASL TLAVNPPDAD QKGPVFLKEP TNRIDFSNST
GAEIECKASG NPMPEIIWIR SDGTAVGDVP GLRQISSDGK LVFPPFRAED YRQEVHAQVY
ACLARNQFGS IISRDVHVRA VVAQYYEADV NKEHVIRGNS AVIKCLIPSF VADFVEVVSW
HTDSEENFYP GSEYDGKYLV LPSGELHIRE VGPEDGYKSY QCRTKHRLTG ETRLSATKGR
LVITEPVGSV GPRINLANRR NDAEVAIGKT VSIFCPAQAY PVPFFRWYKF IEGTTRKQAV
VLNDRVKQVS GTLIIKDAVV EDSGKYLCVV NNSVGGESVE TVLTVTAPLS AKIDPPTQTV
DFGRPAVFTC QYSGNPIKTV SWLKDGKAMG HSDPVLRIES VKKEDKGMYQ CFVRNDQESA
EASAELKLGG RFDPPVIRQA FQEETMEPGP SVFLKCVAGG NPTPEISWEL DGKKIANNDR
YQVGQYVTVN GDVVSYLNIT SVQANDGGLY KCIAKSKVGI AEHSAKLNVY GLPYIRQMEK
KAIVATETLI VTCPVAGYPI DSIVWERDNR ALPINRKQKV FPNGTLIIEN VERNSDQATY
TCVAKNAEGY SARGSLEVQV MVLPQIVPFS YDDIINTGDF VELFCQVQKG DRPIKINWSF
EHPAEYTNYN SQQLIMRTNR VSSKSSILSI PRATPEHTGT YTCTASNAAG FTSYSTNLTV
NVPPRWILEP TDKAFAQGSD AKVECKADGF PKPQLTWKKA VGNSPGEYKD LKKNDNIRVE
EGTLHIDNIQ KTNEGYYLCE AINGIGSGLS AVIMISVQAP PEFTEKLRNQ TARRGEPAVL
QCEAKGEKPI GILWNMNNMR LDPKNDNRYT IREEILSTGV MSSLSIKRTE RSDSALFTCV
ATNAFGSDDA SINMIIQEVP EMPYALKVLD KSGRSVQLSW AQPYDGNSPI TRYIIEFKRS
RASWDEIDRV MVPGDTTEAQ VQKLNPATTY NIRIVAENTI GTSQTSEAVT IITAEEAPSG
KPQNIKVEPV NQTTLRVTWK PPTRSEWNGE ILGYYVGYKL SNTNSSYVFE TVNFLTEEGK
EHNLDLTNLR VYTQYSVVIQ AFNKIGAGPL SDEEKQFTAE GTPSQPPSDT SCTTLTSQTI
RVSWVSPPLE SANGVIKTYK VVYAPSEEWY DETKRHYKKT ASSDTVLHGL KKYTNYTMQV
LATTAGGDGV RSVPIHCQTE PDVPEAPTDV KALVMGQAAI LVSWRPPAQP NGIIQQYTVY
TKVEGAEGEP KSQKIPHYQM SYEATELEKN SPYEFWVTAS TNIGEGQPSK SIVAMPSDQV
PAKIASFDDT FTATFKEDAK MPCLAVGSPQ PEITWKIKGV EFTGNDRMRV LPDGSLLIKS
VNRQDAGDYT CHAENSIAKD SITHKLIVLA PPMSPQVTLS ATTTDSLTVK VKPHEGDTAP
LHGYTLHYKP EFGEWETAEV AVDAQKFNIE NLLCGSRYQV YATGFNNIGA GEASDILNTR
TKGYKPKLPE KSRFIEVSSN SVSLHFKAWK DGGCPMSHFV VENKKRDQIE WNQISNNVKP
DNNYVVLDLE PATWYNLRIT AHNSAGFTVA EYDFATLTVT GGTVAPLDDG RGSGNLHTRI
RLPAWMPEWL DLNFMVPLIA TVIVVFVGIL VVCVALSRRR SDDLRGGQKD VYYDVVYNQT
MGPGATLDKR RPDLRDELGY IAPPNRKLPP VPGSNYNTCD RIKRARGGMR SNHSTWDPRR
PNLYEELKAP PVPAHNNHYG HVHNINECTY KHPGMEDEIC PYATFHLLGF REEMDPTKAM
NFQTFPHQNG HAPPGHAGTM GPPGHPGHMH SRSGSQSMPR ANRYARKNSQ GGQSSIYTPA
PEYDDPANCA EEDQYRRYTR VNSQGGSLYS GPGPEYDDPA NCAPEEDQYG SQYGGPYGTP
YDHYGSRGSM GRRSVGSARN PGGNSSPEPP PPPPRNHDMS NSSFNDSKES NEISEAECDR
DHGPRGNYGE DTKDAVKRSP IHKDQRTTEE MRKLIESRRH LNEAGPKQLQ QQSGAGFTAY
DTMAV
//
