ID A0A1I8Q779_STOCA Unreviewed; 714 AA.
AC A0A1I8Q779;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Netrin-1 {ECO:0008006|Google:ProtNLM};
GN Name=106092041 {ECO:0000313|EnsemblMetazoa:SCAU014539-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU014539-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU014539-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU014539-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_013114237.1; XM_013258783.1.
DR AlphaFoldDB; A0A1I8Q779; -.
DR STRING; 35570.A0A1I8Q779; -.
DR EnsemblMetazoa; SCAU014539-RA; SCAU014539-PA; SCAU014539.
DR KEGG; scac:106092041; -.
DR VEuPathDB; VectorBase:SCAU014539; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..714
FT /note="Netrin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009327905"
FT DOMAIN 47..340
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 397..459
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 460..509
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 544..713
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT REGION 520..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 427..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 460..472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 462..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 481..490
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 493..507
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 714 AA; 79574 MW; D914222C1406AAD7 CRC64;
MNRLLGLLVL ALCGLSLPLT IEGIPSDVYL KMFSAQAPTD PCYDEDKARK CIPDFVNAAY
GAPVVASSTC GMDNPQRYCE SAASALTGSM NQDVSCSICD NSNPQRRFSA VALTDLNNPN
NVTCWRSEPI APVSNPNAPP DNVTLTLSLG KKYELTYVSL QFCPKAPKPD SIAIYKSSDY
GKTWQPFQFY SSQCRRVYGR PNRATITKHN EQEARCTDSH RHTSDIMGSL QGSRIAFSTL
DGRPSARDLD SSPVLQDWVT ATDIKVIFHR LQMPDSNALI TLDSPAEKSS DIKSGKYSEP
NSLIISSLDQ TNSIIGGSAT TLATSSGLHY AVSDFSVGGR CKCNGHASKC ITDHHGLLSC
ECKHNTAGRD CERCKPFHFD RPWGRATARD ANECKICNCN NHARQCRFNM ELFKLSGRVS
GGVCQNCRHS TTGRHCHYCK EGFYRDPSKP LNHRRVCKPC ECHPIGSTGK TCNHTSGQCP
CKDGVTGLTC NRCARGYQQS RSHIAPCIKI PPRISNMLDT QNTAPEPNPH DSASPYRTEG
GRECEKCKIS TKRLNLNKFC KRDYAIMAKV IGREQSTEVT SSEQYNTKEN QKMNDADSDE
MGNDRNAEEA EEEGEDTTVK YIIQIQAIFK RTPLEYATTN TILRRGPMTW IIPIKNLECR
CPKIKMNKSY LILGKDSEAP PGYLGIGPRS IVIEWKDEWY RRMKRFQRRA RTCE
//
