ID   A0A1I8Q9J7_STOCA        Unreviewed;      1480 AA.
AC   A0A1I8Q9J7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SCAU015140-PA};
GN   Name=106084945 {ECO:0000313|EnsemblMetazoa:SCAU015140-PA};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU015140-PA, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU015140-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU015140-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013104382.1; XM_013248928.1.
DR   STRING; 35570.A0A1I8Q9J7; -.
DR   EnsemblMetazoa; SCAU015140-RA; SCAU015140-PA; SCAU015140.
DR   GeneID; 106084945; -.
DR   KEGG; scac:106084945; -.
DR   VEuPathDB; VectorBase:SCAU015140; -.
DR   OrthoDB; 2970602at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.2950; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1480
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009327990"
FT   DOMAIN          536..670
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          775..867
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1387..1477
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   1480 AA;  166714 MW;  951D90BC93D3F614 CRC64;
     MKQFICFIFV IWGFSISVNA NGYYTIVAPG SIQSDTEYAV TVSLHNNPEP ATIKVGITGP
     SYNESKTIEL SAYTAETLKF NVPSLVEGTY ELQTEGMSGM IFKRFSNLTF SKPERHIYLQ
     TDKALYKPGE LVKYRVVVLD SDGKPLKTNN DLAVRIYDSA HNVIQELKEL QFTKGVYSGK
     FKLSEQPVMG DWTIEVLNVK ERQLQLQNKP SLPATVQGGQ FMPSMQYAHP GQYVPGMQNA
     RPMQVFPGMQ GPYPRQFVPG TQVTHTYAGR KAFKNFEVAK YVLPKFSVEI EADEKIAILD
     KTFKVTVRAK YTHGQPVQGN TTITASFVHQ THFDNNLPAA QKTVEIYGKA DVEFDLNQDL
     AMDQFIPRIK IIATVTEGHT GLQQNTSTII NLHQARYTID VDMKDKKFVT NIPFEIKAII
     KKLNGSPVTN AKSTAKLILK RDSHDLNGLI FEADVDTKGM AVFKIKIGWP MSYNSIKVIY
     EEKEHTTYGF RVERPAEPEV KETVIKPSAV STPKTYYPSQ GVYVHPHPSI ERVGPLKVTI
     QKLDFNPDHD VIIEVKSDDP IPYYFYTIMA RGKIIKHEYV KVDGNQKYHR LKIQTTNEMA
     PRAKLFVYLI DDGEMKSDEE DIFIPLKLQN KLEITAPEKA NASELVSLNI KADPDSFVGL
     LAVDQSVLLL KTGNDFDKEK ILDNIGNVKP RAPDTNGRHE TYPGKNSGFV TITNACYPRA
     SYHQYEEQAL RYDTSYRPTG ASYAMPGMGF ASPAAMSFAS PSNDPPVIRK NFVETWIFDD
     IESTDSEGIA NFTRNIPDTM TSWVITGFSL NENTGFGMTE NATNILVSQP FFVSLNLPYA
     VKRGEIVNIP VVVFNYMATQ VEAEITMENV DDEYDFVGTD GNVLTDKVMS QQVTVPTNIG
     NVVSFTIFPK RVGYITLKVK AVTPLAGDIV HQKLKVEPEG VTQYKNEALF VNIPANGEPL
     KHTFKAEIPA DAVVDSEFIE FTAVSDLLGP TIENIDRLVR MPYGCGEQNM INFVPNILVL
     DYLETMQIDN PTLTEKAKAF MLNGYQRQLT YKHQNGAYSS FGESHSNPDN WLTAYVARSF
     IRARKYITID EMLIENALEY LASTQEESGE FVSMRYNFYS TKQSDGVGKT AYILLAFLEN
     QEYALKFKTQ IRKGLNYLQS HFANEDDLHT LALISLVFQR ANHDSLPKLL VKLEHRSHNE
     NNLKWWKTSE KYRSNDIEIT AYILQTLLES KDVDATTVLP TLKWLVGKRN SLGGFASTQN
     TVVGLEALIK FAEKFAAAGR GSISIKFHTQ NEAGEEISSN EFTIDETTGL GLISHEFNRS
     TRQLTVSAEG QGSALLQFSY RYNLVTKDDN AGFLIRYSLN KESTSDHISM NVCAEYEAEA
     DDEIKESNMA VMEIYLPSGY KTDHDSLQFI PSTALVQRVD TKNDETVIIV YFDMLFAGEP
     ICFDIFAENY HKVDKLKPAA ITVYDYYNSK KRATVFYEVK
//