ID A0A1I8Q9N1_STOCA Unreviewed; 1391 AA.
AC A0A1I8Q9N1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN Name=106092329 {ECO:0000313|EnsemblMetazoa:SCAU015128-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU015128-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU015128-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU015128-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000478};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.25; Evidence={ECO:0000256|ARBA:ARBA00000106};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
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DR RefSeq; XP_013114614.1; XM_013259160.1.
DR STRING; 35570.A0A1I8Q9N1; -.
DR EnsemblMetazoa; SCAU015128-RA; SCAU015128-PA; SCAU015128.
DR GeneID; 106092329; -.
DR KEGG; scac:106092329; -.
DR VEuPathDB; VectorBase:SCAU015128; -.
DR OrthoDB; 5388799at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046872; DRHyd-ASK.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF369; APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20309; DRHyd-ASK; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 608..866
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 637
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1391 AA; 159276 MW; 14F68CD437C25687 CRC64;
MANNAAASVS TKPQQQQQQQ QPGQWNTQML TVVCVIDTQL GDHLKDRECA LEEIQQAVTS
VGANFQRVQF DKLDFGETKK LETFYNADVA VIDLSIQSHQ RSLSYHLGVR ESFNMKENIL
IYNDVHSKQT LSLKLSFPNY TFLSYKLNTE YGVCNLTNFN KELPADTKIP TLQVRLKRLL
QDVEIQSKAH MREKFLTDLR QAREIYATNT KKLQSILHEM RKRLDDGHVL SGEVVHSFMC
SLRDVQDYDA MVCLVNDLKN IPNTRKYVET GNMSFLYAFA LNRRNKKGDR EKALESSLKA
LEKKENEFPD MLCLCGRIYK DIFVESDYSD TVSLKNAIKW YRQSFEVQPN EYAGINLATL
LVIDGKEFSN TEELQHIGMT LNNLIGKKGS LSSLTEYWDV ATFFEISVLA EDYAKAIKAA
ECMFKLKPPG WYLKSTIGNI SLIHRFRKKG DDHQPNIEEQ IFQFWMDFFL DATDSTKISN
IRFPILILEP QKIYMPSYVN INMDAEEKSI QIINICLAHA KQECKKVHDF VFTASQIKSV
SLYKRDDRCA YLYVHHNSDD FQIYFPSPEC RQRFYELILE MASDQDVFVN LNEEEPQQIE
YEYDYDDQNR KIVLGKGTYG TVYAARDKHT QVRIAIKEVP EKNSQDVQPL HEEIKLHSQL
RHRNIVRYLG SLSEDGYFKI FMEQVPGGSL SDLLEKKWGP LKDNESTMAF YSKQILEGLK
YLHEQKIVHR DIKGDNVLVN TYSGVVKISD FGTSKRLAGI NPMVSTFTGT LQYMAPEVID
LGFRGYGPAA DIWSFGCTNV EMATGKRPFI ELGSAQAAMF KVGYYKKHPT IPDELSPNAK
NFILRCFAIQ ETERPTAAQL LEDPFLTDKH RKLRLGPPSS SDFSRSISVP ADRLFSKPRA
GNTPTTPEIE GFHSTSVDIE NLPSHQSFNM ERRNSSGTLL SPEIEVSTPS LRTGASSETS
ETNDFYHLKK ESQRRTTLSN ILTTDESKIC DLWLEKLNAA QNNIVAISKN ELVKLIHGMR
EYIMNEKEKH LEACINSLKE ELNYDVVALD HLHLALYSFQ DAVIPVLRSH SIKPHWMFAL
DNLVKQAVQA CVMILYPELG ANLLGKEPSL IDDESVHNQQ QTSTDSQEKI VVYDAAQAPH
STTPAMDEDS TSFSSSECVR LLRDIKESNR KFHYQHLEHQ KQSLKALQNI SKELAHFYMG
RKRTRRPRST AVGNKKPNRQ YKRQFARRSV TSYNGGLQEV DEQLEEWLTR HDVDEVSKNI
ILNEGFSYED FIYNMEKFDL MRLELRLGIE VRIWSLILQI RSQNYASNAT NSSGERTSPN
ATSSYVNNTN AYSDSNALNS LNNNNTTASM SNLNNNPVAL NHKPIRSSLR RNSSKHCDSE
YVSCSEDQTS T
//
