ID   A0A1I8QAW1_STOCA        Unreviewed;       800 AA.
AC   A0A1I8QAW1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN   Name=106092525 {ECO:0000313|EnsemblMetazoa:SCAU015448-PA};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU015448-PA, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU015448-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU015448-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   RefSeq; XP_013114858.1; XM_013259404.1.
DR   AlphaFoldDB; A0A1I8QAW1; -.
DR   STRING; 35570.A0A1I8QAW1; -.
DR   EnsemblMetazoa; SCAU015448-RA; SCAU015448-PA; SCAU015448.
DR   KEGG; scac:106092525; -.
DR   VEuPathDB; VectorBase:SCAU015448; -.
DR   OrthoDB; 3676611at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009975; F:cyclase activity; IEA:UniProt.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06352; PBP1_NPR_GC-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR001170; ANPR/GUC.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR11920:SF274; GUANYLATE CYCLASE; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   PRINTS; PR00255; NATPEPTIDER.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        49..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          637..723
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   800 AA;  88157 MW;  D3EC3E851D631E3E CRC64;
     MGVRGIMRCK NTNNHSSARK LSFSSSSRTI LPSPLPFGIQ RGFSSNANIL IACGCCLVLI
     ITTLVIVYET KHIMNEDKTY WQLDVNDAEY SSSGSQNMDD VNMKYLAYDL QSLAAGSISN
     SNEYFLGSAL YYDEGGDGGG GGSGNGASAA VGSESGVAIG NGLAVSNAVA ADDVKLRRKR
     ETVEYDEMGN RVYNVGVLMA SRLDSPFDLE RCGPAVDLAL DAINKEFLRP HNITLRKVQA
     SYPSCSGAKA PGLAADMHFK NDVIAFVGPA CAFALEPVAR LAAYWNSPII TGMGDQPPSE
     GELTVTSGIL GRIHKWKNES TGMFKDKTKY PTLTRMSYCQ CRLKLVFASV FRQFNWKHVA
     LLVDRSDLFS LTVGKNLEYG LRQEGLLSFV RELNGNEQEH YDTYLRDASM YARVVILSVR
     GTLVRKFMLA AYSLGMTNGD WVFLDVEIFQ SSYWGDHDWE MGDADDSRAR KAYEALLRVS
     LLQPSSPTYQ GFSDHVKEMA YLNYNYTFEE GEEVNFFIGA FYDGVYLLGM ALNETLSEGE
     DIRDGMAITR RMWNRNFDGI TGHVRIDDNG DRDADYSILD LDPINGKFAV VAHYYGLHSH
     HAVYVSNGLL LAICINPLRG MGLIISPLSK TGVYIPVETI GDAYMVVSGL PERNADNHAR
     EIGLMALAIL DAVKSFSIKH KPEYQLKIRI GIHSGPVCAG VVGQKMPHYC LFGDTVNTAS
     RMESTGMPLR IHVSSAAKVI FDKFGTFEME LRGEVEVKGK GTVTTYWLVG CSEPDPRPPT
     PHKNNNDDVP FPILFPAIGK
//