ID A0A1I8QBU8_STOCA Unreviewed; 1961 AA.
AC A0A1I8QBU8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Myosin heavy chain, muscle {ECO:0008006|Google:ProtNLM};
GN Name=106082291 {ECO:0000313|EnsemblMetazoa:SCAU015727-PO};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU015727-PO, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU015727-PO}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU015727-PO};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013100147.1; XM_013244693.1.
DR EnsemblMetazoa; SCAU015727-RO; SCAU015727-PO; SCAU015727.
DR VEuPathDB; VectorBase:SCAU015727; -.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14909; MYSc_Myh1_insects_crustaceans; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.140.910; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..776
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 655..677
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1821..1861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1921..1961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1961 AA; 224224 MW; 8C04A83564569BCB CRC64;
MPRPIASQED EDPTPYLFVS LEQRRIDQSK PYDSKKNCWV PDEKEGYLLG EIKATKGDVV
SVGLPGGETK DFKKDKLQQV NPPKYEKAED MSNLTYLNDA SVLHNLRQRY YNKLIYTYSG
LFCVAINPYK RYPVYTNRCA KMYRGKRRNE VPPHIFAISD GAYVDMLTNH VNQSMLITGE
SGAGKTENTK KVIAYFATVG ASTKKDESQK NKGSLEDQVV QTNPVLEAFG NAKTVRNDNS
SRFGKFIRIH FGPTGKLAGA DIETYLLEKA RVISQQSLER SYHIFYQIMS GSVAGVKEYC
LLTDNVYDYH IVSQGKITVA SIDDADEFTL TDQAFDILGF TKQEKEDVYR ITAAVMHMGG
MKFKQRGREE QAEQDGEEEG GRVAKLFGCD CAELYKNLLK PRIKVGNEFV TQGRNVQQVT
NSIGALCKGV FDRLFKWLVK KCNETLDTKQ KRQHFIGVLD IAGFEIFDYN GFEQLCINFT
NEKLQQFFNH HMFVLEQEEY KKEGINWDFI DFGMDLLACI DLIEKPMGIL SILEEESMFP
KATDQTFSEK LTNTHLGKSA PFQKPKPPKP GQQAAHFAIG HYAGVVAYNI TGWLEKNKDP
LNDTVVDQFK KSKNALLVEI FADHPGQSGG GDAKGGRGKK GGGFATVSSA YKEQLNSLMT
TLRSTQPHFV RCIIPNEMKQ PGLVDAHLVM HQLTCNGVLE GIRICRKGFP NRMVYPDFKQ
RYQIINPAGI LTASDLKKQS QIILESTPLD ADMYRIGHTK VFFRAGVLGQ MEEFRDERLG
KIMSWMQAWA RGYLARKGFK KLQEQRVALK VVQRNLRKYL QLRTWPWYKL WQKVKPLLNV
SRIEDEIARL EEKAKKAEDA HAAEVKVRKE LEALNAKLLA EKTALLDSLS GEKGQLSDFQ
ERCSKLQAQK SDLENQLRDI QDRLTQEEDA RNQLFQQKKK ADQEISGLKK DIEDMELNIQ
KAEQDKSTKD HQIRNLNDEI AHQDELINKL NKEKKMQGES NQKTGEELQA AEDKINHLNK
VKSKLEQTLD ELEDSLEREK KLRGDVEKSK RKVEGDLKLT QEAVADLERN KKELEQTIQR
KDKELGALTG KLDDEQVVVN KNNRQIKELQ ARIEELEEEI EAERQARAKA EKQRADLARE
LEELGERLEE AGGATSAQIE LNKKREAELS KLRRDLEEAN IQHESTLANL RKKHNDAIAE
MAEQVDQLNK MKAKAEHDRQ TCHSELNQTR TACDQLGREK AAQEKIAKQL QHTLNEVQSK
LDETNRSLND FDAAKKKLSI ENSDLLRQLE EAESQVSQLS KIKISLTTQL EDTKRMADEE
SRERATLLGK FRNLEHDLDN FREQVEEEAE GKADLQRQLS KANAEAQLWR SKYESDGVAR
AEELEEAKRK LQARLAEAEE TIESLNQKCI GLEKTKQRLS TEVEDLQLEV DRANAIANAA
EKKQKAFDKI IGEWKLKVDD LAAELDASQK ECRNYSTELF RLKGAYEEGQ EQLEAVRREN
KNLADEVKDL LDQIGEGGRN IHEIEKARKR LEAEKDELQA ALEEAEAALE QEENKVLRAQ
LELSQVRQEI DRRIQEKEEE FENTRKNHQR ALDSMQASLE AEAKGKAEAL RMKKKLEADI
NELEIALDHA NKANAEAQKN IKRYQQQLKD IQTALEEEQR ARDDAREQLG ISERRANALQ
NELEESRTLL EQADRGRRQA EQELADAHEQ LNEVSAQNAS ISAAKRKLES ELQTLHSDLD
ELLNEAKNSE EKAKKAMVDA ARLADELRAE QDHAQTQEKL RKALEQQIKE LQVRLDDAEA
NALKGGKKAI QKLEQRVREL ENELDGEQRR HADAQKNLRK SERRVKELSF QSEEDRKNHE
RMQDLVDKLQ QKIKTYKRQI EEAEEIAALN LAKFRKAQQE LEESEERADL AEQAISKFRA
KGRGGSVGRG ASPAPRAMSM RPQLDGMAFP PRFDLAPENE F
//
