ID A0A1I8QC74_STOCA Unreviewed; 529 AA.
AC A0A1I8QC74;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN Name=106080812 {ECO:0000313|EnsemblMetazoa:SCAU015777-PE};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU015777-PE, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU015777-PE}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU015777-PE};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR RefSeq; XP_013097834.1; XM_013242380.1.
DR AlphaFoldDB; A0A1I8QC74; -.
DR EnsemblMetazoa; SCAU015777-RE; SCAU015777-PE; SCAU015777.
DR VEuPathDB; VectorBase:SCAU015777; -.
DR OrthoDB; 1020411at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:InterPro.
DR CDD; cd15900; EFh_MICU; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..305
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 463..498
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 102..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 60365 MW; 0914B2E1F4FF32EF CRC64;
MSILRQCGTM AAQFVQPHRV LARGSFGLLP AVVKRMNVPS SENGTPFNAR GHKNFGHKKQ
ITPNITRIFH FIVGSLFLIS IMDWTKVKRF VMPKVDADAG VEPADVEKKS RKKDKKSKDS
KAATDSESES DSEVEGAEGK DDSLEEKSKS VRGAKEKVGF RERKIVEYEN RIRQFSTPDK
VFRYFATIQV ATSDDRHEIF MTPTDFLTSM TPGMKQPEGL GLDQYRRYDP KSVGESLNLN
LEKNSIFYKL GSYGLITFSD YIFLLTVLST SRRHFEIAFQ MFDLNGDGDV DCEEFEMVAT
LVRQQTSIGS RHRDHANTGN TFKSKGVNSA LTTFFFGPNL DKKLTIQKFL DFQHQLQREI
LSLEFERKHP DENGLITEAD FGELLLAYAG YPIKKKQKKL KRVKRRFRDH SIGISKKDYL
DFFHFLNNIN DVDTALTFYH IAGASIDQAT LKHVAKTVAM VELSDHVIDV VFTIFDDNND
NQLSNREFIS VMKNRVQRGL EKPKDTGFIK LMRSMLKCAK ETKPVLLDL
//
