ID A0A1I8QCE6_STOCA Unreviewed; 1275 AA.
AC A0A1I8QCE6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Neurexin-4 {ECO:0008006|Google:ProtNLM};
GN Name=106089413 {ECO:0000313|EnsemblMetazoa:SCAU015849-PB};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU015849-PB, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU015849-PB}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU015849-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_013110706.1; XM_013255252.1.
DR AlphaFoldDB; A0A1I8QCE6; -.
DR STRING; 35570.A0A1I8QCE6; -.
DR EnsemblMetazoa; SCAU015849-RB; SCAU015849-PB; SCAU015849.
DR KEGG; scac:106089413; -.
DR VEuPathDB; VectorBase:SCAU015849; -.
DR OrthoDB; 4255614at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1275
FT /note="Neurexin-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009328143"
FT TRANSMEM 1209..1229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..175
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 179..359
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 365..531
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 533..570
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 787..953
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 954..990
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 992..1174
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1245..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1275 AA; 144220 MW; 5712026E612C7140 CRC64;
MRNFFLALLL SFDLYLFSSL KSVVADSYSD YFSDYECNTP LMEKAILSAT SALNDRGPEK
ARLNAGTSWS AKNSDFDQRL IIDLGYVKNV THIALQGRPH SNEFVTEYAI SYGITDLEFA
DYKEPGGNIK MFKGNSDGNS IHYNVFEVPI IAQWIRINPT RWHDRISMRV ELYGCDYVAE
NLYFNGTGMV RYNLLQEPIA STRESIRFRF KTANANGIMM YSRGTQGDYF ALQLMENKMM
LNLDLGGGIM TSLSVGSLLD DNVWHDVVIS RNRRDIIFSV DRVIVRGRIK GEFSRLNLNR
ELYLGGVPNI QEGIYVTQNY SGCMENIFFN STNFIREMKD SYERGESYRF NKFNTVYACP
SPPIYPVTFT TRGSFVRLKG YEGQKSLNVS FYFRTYENDG MMLHHDFANG GYVRVFLEKG
KVKVDLKLSD KPRIILDNYD ERFNDGKWHA FILAIQRNRL VLDIDQRPMA TTKNIQISTG
RIYYIAGGME KNNGFVGCMR LILVDGNYKL PKDWVQGEEV CCGDEVVVDA CQMIDRCNPN
PCQHNGNCHQ DSTDFFCDCD QTGYAGAVCH TSNNPLSCQA LKNVQHVQSR VTTKIDVDGS
GPLKPFPVTC EFYTDGRVIT TLSHSQEHTT TVDGFQEPGS FEQNILYDAD MQQIEALLNR
SHSCWQRLSY SCRSSRLFNS PSEITNFRPF SWWVSRHNQP MDYWAGALPG SRKCECGILG
KCQDPTKWCN CDSNSLEWAE DGGDIREKEY LPVKAVKFGD TGTPLDEKQG RYTLGPLRCE
GDDLFSNVVT FRIADATINL PPFDMGHSGD IYLEFKTTVE NAVIFHATGP TDYIKLTIIG
GNKLQFQYQA GSGPLGVNIG TSYHLNDNEW HTVSVERNRK EARLVVDGSI KAEVREPPGP
VRALHLTSDL VIGATTEYRD GYVGCIRALL LNGKMVDLKQ HAERGMYGIS SGCVGRCESS
PCLNNGTCIE RYDGYGCDCR WSAFKGPICA DEIGVNLRSN SIIRYEFVES FRSTIAENIR
VGFTTTIPKG FLLGFSSNIT GEYLTIQISN SGHLRCVFDF GFERQEIIFP KKHFGLGQYH
DVRFSRKNSG STVVLKVDNY EPVEYNFDIK ASADAQFNNI QYMYIGKNLS MTDGFVGCVS
RVQFDDIYPL KLLFQQNPPS NVKSLGSQLT EDFCGVEPVT HPPTEVETRP PPLVDEEKLR
KAYNEVDTAL LAILLIILFL LLILMIFLIG RYLHRHKGDY LTHEDQGADG ADDPDDAVVH
STTGHQVTKR KEWFI
//
