ID A0A1I8QD43_STOCA Unreviewed; 415 AA.
AC A0A1I8QD43;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN Name=106094981 {ECO:0000313|EnsemblMetazoa:SCAU016038-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU016038-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU016038-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU016038-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR RefSeq; XP_013117677.1; XM_013262223.1.
DR AlphaFoldDB; A0A1I8QD43; -.
DR STRING; 35570.A0A1I8QD43; -.
DR EnsemblMetazoa; SCAU016038-RA; SCAU016038-PA; SCAU016038.
DR GeneID; 106094981; -.
DR KEGG; scac:106094981; -.
DR VEuPathDB; VectorBase:SCAU016038; -.
DR OrthoDB; 3259424at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..415
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5009328132"
FT DOMAIN 27..86
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 163
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 342
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 373
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 415 AA; 46695 MW; F5F17297A5FADB9E CRC64;
MQTLTAFVIF LLAVVVTSAG AVDTCDRIIQ HGYPCGRHNL TTSDGYRLTM FRIPHSHRGD
PQHNVTDKPP VLFMHCVECS SDIWILVGPD SALPFMLADA GFDVWLGNAR GNMYSEEHVT
MERSSIAFWA FSLDELGTID VPAKIDYILA KSKKKSLHFV GYSQGTTNFI AALSNKPEYN
DKIRSSHLLG PVVFLCHVGG PFPVLASPLV GSDNPFAHML GTLVGTVPLH ELTALARSVA
LALCTRPDFE EMCVGIMNII AGWDSPYLNR SVIPELLSTF PAGCSFRQFV HYAQNVMSCD
FRYFDFGLAG NMLKYGQAKP PSYNLSNVHP ETPMELYFAD NDNFVPARDI YHLYKIFGKR
ASWNRVKHTK YNHNDYAMAY NVKECLYDCI LDKMQEYERR PFKGDQCTCF KKNAF
//
