ID   A0A1I8QDU9_STOCA        Unreviewed;      1209 AA.
AC   A0A1I8QDU9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   Name=106089140 {ECO:0000313|EnsemblMetazoa:SCAU016197-PA};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU016197-PA, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU016197-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU016197-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013110372.1; XM_013254918.1.
DR   AlphaFoldDB; A0A1I8QDU9; -.
DR   EnsemblMetazoa; SCAU016197-RA; SCAU016197-PA; SCAU016197.
DR   GeneID; 106089140; -.
DR   VEuPathDB; VectorBase:SCAU016197; -.
DR   OrthoDB; 2971287at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166:SF63; STRAIGHTJACKET, ISOFORM C; 1.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   DOMAIN          263..445
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   1209 AA;  139487 MW;  A10083F985C9234C CRC64;
     MLIREVCSFL FRIYISFYIV HWPNGGSLVV SGEKINYNLV HSWADKLGME LFHLGDFITR
     RKEVQESFKQ AQVVTRSGAK IVENMANEIK IMMDSKISAV RRIMDTAENT ALTYQMEKPD
     QLFSYYNSKE MIEPGEPIPT KPPRDLEDAG AEKIFVTPKT IVLTPKEEFF NTPVNMSVSS
     VHVPTNVYDR ALDTIKAIEW SENLDQIFRD NYKNDPTLSW QFFGSSTGFM RQFPASKWKM
     EPVDLYDCRL RPWYMEAATS PKDVIILLDS SGSMMGQRLD IAKHVVNTIL DTLGTNDFVN
     IFTFSDKVKP VVGCFEDTLV QANLGNIREL KEGIETVKTV SIANFTAALT KAFEVLEQFR
     TEQHGAQCNQ AIMIVSDGAP FSYEEIFELY NWQNLPYKPV RVFTYLIGKE VADVKDIKWM
     ACANQGYYVH LADTAEVREM VLNYIPVMAR PLVLGRHDHP VIWTQVYADV EDTEMSDYLW
     QNEQNNDQKE NILEYRKVSF RMLDPDEVRR REYRRMRKAW DQPTDTDIYK FMTTISMPVY
     DRRENATRVA NLLGVAGTDV PIRDIKRLLS PFLLGVNGYA FVVTNNGYIL FHPDFRPIFQ
     GYILKPAYNS VDMIEVELLD DDRPPRDFNP VLLTIRDSII NQSTGSKWML VKNHFDEMKR
     VARVKRQYYW TAIKNTPFTL VITYPELYGV NRLQIRTEDE IHRISIKGSN TLSFFTGKRW
     KIHPKWLFCK HSNMTFQSPE EELLWFLGKM SQPGWKWPSS RSALPPEHTA AMFSNTSAGR
     IPPFDNYYCD RQLMQSLVFD ARVTEWFSKN TSFNSKDDKG NEFKQRFGIN VAFLATHSGL
     TRWQEFHSNM AEEQGAGDKF SETNNKAIDE VWYKRAVDQH FVREESFVYS VPFDAGETSP
     DPIVTASHAI FHSEGGKSAP AAVVGFQFQY SALHKLFRNI TGNACAVDDK SCYVLDNNGF
     IIVSLNRHET GRFFGEINGA IMHRLVEENV YKRVIVYDYQ AICFVPDGDM NCSPNILSPL
     VHVFKAFRWL LSTLVLYLLE ISAVAADFFE HYVDENMTDY MVNVKNNEWV RLVTLQRTRL
     KQCDMQRELY TLYNATGNVV YNMTAHGCER PFVVLPIPAS NLILLVIDQM CPRDVTHVLT
     VNPMDINYPL DENQTLACFK KDHEFSRVRP TSCINKHINE SNIELCGNAS SIFINVFLFI
     IALCSSRFL
//