ID A0A1I8QF31_STOCA Unreviewed; 1085 AA.
AC A0A1I8QF31;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 08-NOV-2023, entry version 32.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN Name=106085850 {ECO:0000313|EnsemblMetazoa:SCAU016551-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU016551-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU016551-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU016551-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR RefSeq; XP_013105750.1; XM_013250296.1.
DR AlphaFoldDB; A0A1I8QF31; -.
DR STRING; 35570.A0A1I8QF31; -.
DR EnsemblMetazoa; SCAU016551-RA; SCAU016551-PA; SCAU016551.
DR GeneID; 106085850; -.
DR KEGG; scac:106085850; -.
DR VEuPathDB; VectorBase:SCAU016551; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:UniProt.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 299..470
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 21..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1085 AA; 122753 MW; 4695C8DF8F38467E CRC64;
MIHKPPIIKI RNLKELQCSQ KAKAELEDPN ATPIKAKKPR RKAATTGTKA KKVTLPNEEI
EQERHTPKVE NPDVAPPPAA STVKRLSKSA RKEPPPSQLR INIFFKPCEK TYKIEPLKEQ
PTPLRKAATE IKKQVSKTTT TKKNGKVIKN RRSKMGRKRL FTDNDTSSTM NSDSDTSNQK
RAMSAKEKGS SNITEVCINL ISDSDDDDAF EKKTIKIEKK ENSVDAKTSG NNSRVSRSSS
VTYNGVSKTH TVTTTAPMAC DSGTSKAHIS PNTATSTSSP TATIAAVKTP ATTRRKPKPC
PPYKIIEGST FAVDAFQYGY IEGVTHYFLT HFHADHYIGL TRKFAMPLFM STITARFVRA
FIPIDEKYIH ELELNTPIDV NGIEVTALDA NHCPGAIMLL FKIKSSSQCI LHTGDFRAWH
GMEEEPVFWN NHINTIYLDT TYLSQKYAFC TQYESIDRAK HLVQEFQAKH AGKSILYICG
SYVIGKERFW SSLAEEFALK VWTEDNRSKA LKAMNDKHLN QLLIENPLEA DMHVIAMGKL
SYMSLVDYFA LYQQRYDICL ALRPSGWEKD TRPQYRGTIN IIGVEYSEHS SYEEMKRFVK
FLKPDNVIST VPTGRDLMKT SKVPESWYKY EKLQQSSNYQ PRIEQYLRKS TPMRKAIIRG
PNPNKGGIES AVSPLSMKNV RNKREKDKNN NCEDSNSVIM TNSPAKSTSA NEFENPMVWL
PQSQKNKENS QKKIKQEKSE KNLRLRTSKA RNEVPQLVPD KKKTDENSGK QLKEGDNCSI
YISNDSSELF EKPMPKVACR RRIISCSSDE EFVAKPNKTK LREKRNVFKP SMPSTVEENE
ADFVENSVRS TKKKKADYDN YLDEQPCTSK EALRRLAISN PLLKSTTTSC ASTTTSANEE
VQDSQASDDF ELMARPIRNK NLRKDVIPSS QTTFELKNTP RPLRNKCKTT WHEAKQQHDS
QNDFIPASQT TADLANTPRP LRNKRTNTTP LTSLVTSPVK KGTRPKNNVP LSPISDEDGS
QPELVTQIVK NTKHLDFYNS SQMNVMVQNL LSSQKLDTSK DHIPPELLSD NDALEALDAQ
DDWLD
//
