ID A0A1I9LSK5_ARATH Unreviewed; 5078 AA.
AC A0A1I9LSK5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Auxin transport protein (BIG) {ECO:0000313|EMBL:ANM65563.1};
GN Name=BIG {ECO:0000313|EMBL:ANM65563.1, ECO:0000313|TAIR:AT3G02260};
GN Synonyms=ASA1 {ECO:0000313|EMBL:ANM65563.1}, ATTENUATED SHADE
GN AVOIDANCE 1 {ECO:0000313|EMBL:ANM65563.1}, CORYMBOSA1
GN {ECO:0000313|EMBL:ANM65563.1}, CRM1 {ECO:0000313|EMBL:ANM65563.1},
GN DARK OVER-EXPRESSION OF CAB 1 {ECO:0000313|EMBL:ANM65563.1}, DOC1
GN {ECO:0000313|EMBL:ANM65563.1}, LOW PHOSPHATE-RESISTANT ROOT 1
GN {ECO:0000313|EMBL:ANM65563.1}, LPR1 {ECO:0000313|EMBL:ANM65563.1},
GN TIR3 {ECO:0000313|EMBL:ANM65563.1}, TRANSPORT INHIBITOR RESPONSE 3
GN {ECO:0000313|EMBL:ANM65563.1}, UMB1 {ECO:0000313|EMBL:ANM65563.1},
GN UMBRELLA 1 {ECO:0000313|EMBL:ANM65563.1};
GN OrderedLocusNames=At3g02260 {ECO:0000313|Araport:AT3G02260,
GN ECO:0000313|EMBL:ANM65563.1};
GN ORFNames=F14P3.3 {ECO:0000313|EMBL:ANM65563.1}, F14P3_3
GN {ECO:0000313|EMBL:ANM65563.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:ANM65563.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:ANM65563.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130713; DOI=10.1038/35048706;
RG European Union Chromosome 3 Arabidopsis Sequencing Consortium;
RG Institute for Genomic Research;
RG Kazusa DNA Research Institute;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Blocker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M.,
RA Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N.,
RA Artiguenave F., Robert C., Brottier P., Wincker P., Cattolico L.,
RA Weissenbach J., Saurin W., Quetier F., Schafer M., Muller-Auer S.,
RA Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N.,
RA Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P.,
RA Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S.,
RA Simionati B., Conrad A., Hornischer K., Kauer G., Lohnert T.H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schon O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwalder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.W., Mayer K.F., Kaul S.,
RA Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2] {ECO:0007829|PubMed:19245862}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19245862; DOI=10.1016/j.jprot.2009.02.004;
RA Jones A.M., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E.,
RA Rathjen J.P., Peck S.C.;
RT "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis
RT thaliana.";
RL J. Proteomics 72:439-451(2009).
RN [3] {ECO:0007829|PubMed:22223895}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.M111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [4] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
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DR EMBL; CP002686; ANM65563.1; -; Genomic_DNA.
DR RefSeq; NP_001327522.1; NM_001337389.1.
DR SMR; A0A1I9LSK5; -.
DR ProteomicsDB; 218396; -.
DR EnsemblPlants; AT3G02260.3; AT3G02260.3; AT3G02260.
DR GeneID; 820398; -.
DR Gramene; AT3G02260.3; AT3G02260.3; AT3G02260.
DR Araport; AT3G02260; -.
DR TAIR; AT3G02260; BIG.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; A0A1I9LSK5; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19681; UBR-box_BIG_like; 1.
DR CDD; cd02249; ZZ; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1I9LSK5,
KW ECO:0007829|ProteomicsDB:A0A1I9LSK5};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1564..1635
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 2593..2652
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT ZN_FING 1564..1635
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 1530..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3129..3154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4871..4895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1551
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5078 AA; 565674 MW; 44A7BC6396FF88DF CRC64;
MADDLANLCR FLFDDTAFPS LSSSASSDLF SRRLRSDDSI KRGLRSFYLL LRWGVAPIGG
DDADSSGKLR FETWSDSQLQ ALVSISQAIL LLSRSLLVDQ LEPIVLGVIQ EVMEFSLSFL
EKSSFRQNDL KMEINMEILL EIASFDGSEK QYDILPDFSP AEVAELWPAF SGEHDNMDAQ
SLVKCTFQAG GRCSNEEKPV DRLLITLMSE CIESDVQAQS VVKSPFQQDC GDLNPFTRHL
AVVHLRCVCR LIMVCKELVQ LPNMLDEKTV DQAVLDKLSF CLRILKLLGS LSKDVQSIEN
DGSLLQAVAS FTDAFPKLFR VFFEFTNHTA TEGNIESLSL ALVEGFLNLV QLIFGKSSVF
QNVQACVAAS IVSNLDSSVW RYDGSSCNLT PPLAYFPRSV IYTLKLIQDL KRQPYHIHDL
RVLESEVTYE DVSSTVDSVY FHLRQEKIPL LKCFTVEDIM RVIFPSSSQW MDNFFHLVYF
LHREGVKLRP KVERTYSSLR SNSFAEVESQ ISHDDEALFG NLFSEGSRSL CSIEPNDQPP
VSVSSNLLLQ AAKELLNFLR ACILCQEWVP SIYEDGCKKL DTGHIDILLN IVGCSIEDKA
SDGGCMLQDE GRPGHVAFEL LLNLLRSRAL SDFLESYLFQ QILVVENSDF NYNDKTLALL
AHTLLCRPGL AGAQLRAKIY DGFVSFVTER ARGICAEALS LKELTACLPS AFHIEILLMA
FHLSNEAEKA KFSNLIASCL HKVDTPAGIC DGPQLSSWAM LISRLLVLLH HMLLHPNTCP
TSLMLDLRSK LREVRSCGSN LHVTVGDHLS SWASLVARGI TDSWAEDESV SHLMSQMIDF
SPHPPTFQND VSTAKTLNLD YGDLSASLCR VLGLWKGKKA GKVEDLLVER YIFMLSSDIA
RINCALDSQP SLHVNYQNVD ISNSVDLIST SHLLVGDINV VGRNIELRNI LIGVLNQLQA
APEQVVEDLG WDYIREGAWL SLLLYFLDGG VWDYCNKNSC SEIDPFWKEC TSVDAKYVAA
AEGVVSYLMK TGDIAELLRM LSSLVGKYLR VYKKAFLATF SDWNHHGHSS PSLLLLKHTQ
FGKSLQGEYA KIGDNSLHLQ CIFYLSKLDS LGDGRGSGVL WKVFWEFMVH GFPTSLQTSS
AILLSCILSI RCIVLTINGL LKLGNSKEKF GVDTSVLHQL LDSIMIIKFD QVFESFHGKC
EEIHQNICAV LQLPDLTELF LMKDMEGFVR DISAEQIDRS QVLEGVITKI VDVMDSLSKD
SSKSDIFKFY LGVDAVSEHT REFYELQRGD LSVFIDSLDY CSLEPVNIKV LNFLVDLLSV
AQSPDLRRRV QQKFIDMDLI SLSGWLERRL LGSFVEEIDG KKTAKGNSLP FREAAMNFIN
CLVSSTNDLQ TRELQNHLFE ALLISLDTAF LSFDIHMSMS YFHFVLQLAR EDNLMKMVLK
RTIMLMEKLA AEEKLLPGLK FIFGVIGTLL SNRSPSHGES LCGKSLASYK NTATGPLVPK
LSGTTKKSDT LALPVDQEGS SISLECDVTS VDEDEDDGTS DGEVASLDKE DEEDANSERY
LASKVCTFTS SGSNFMEQHW YFCYTCDLTV SKGCCSVCAK VCHRGHRVVY SRSSRFFCDC
GAGGVRGSSC QCLKPRKYNG NGSAPARGTN NFQSFLPLSE DADQLGESDS DVEEDGFGEE
NHVVLYIPKE TQYKMSLLLE ELGIEDRVLE LFSSLLPSIT SKRDSGLSKE KQVNLGKDKV
LSFDTDLLQL KKAYKSGSLD LKIKADYTNS KDLKSLLANG SLVKSLLSVS VRGRLAVGEG
DKVAIFDVGQ LIGQATIAPI NADKANVKPL SRNIVRFEIV HLSFNPVVEN YLAVAGLEDC
QILTLNHRGE VIDRLAVELA LQGAFIRRID WVPGSQVQLM VVTNKFVKIY DLSQDSISPT
QYFTLPNDMI VDATLFVASR GRVFLLVLSE QGNLYRFELS WGGNAGATPL KEIVQIMGKD
VTGKGSSVYF SPTYRLLFIS YHDGSSFMGR LSSDATSLTD TSGMFEEESD CKQRVAGLHR
WKELLAGSGL FICFSSVKSN AVLAVSLRGD GVCAQNLRHP TGSSSPMVGI TAYKPLSKDN
VHCLVLHDDG SLQIYSHVRS GVDTDSNFTA EKVKKLGSKI LNNKTYAGAK PEFPLDFFER
AFCITADVRL GSDAIRNGDS EGAKQSLASE DGFIESPSPV GFKISVSNPN PDIVMVGIRM
HVGTTSASSI PSEVTIFQRS IKMDEGMRCW YDIPFTVAES LLADEDVVIS VGPTTSGTAL
PRIDSLEVYG RAKDEFGWKE KMDAVLDMEA RVLGHGLLLP GSSKKRALAQ SASMEEQVIA
DGLKLLSIYY SVCRPRQEVV LSELKCKQLL ETIFESDRET LLQTTACRVL QSVFPRKEIY
YQVKDTMRLL GVVKVTSILS SRLGILGTGG SIVEEFNAQM RAVSKVALTR KSNFSVFLEM
NGSEVVDNLM QVLWGILESE PLDTPTMNNV VMSSVELIYS YAECLASQGK DTGVHSVAPA
VQLLKALMLF PNESVQTSSS LAISSRLLQV PFPKQTMLTT DDLVDNVTTP SVPIRTAGGN
THVMIEEDSI TSSVQYCCDG CSTVPILRRR WHCTVCPDFD LCEACYEVLD ADRLPPPHTR
DHPMTAIPIE VESLGADTNE IQFSADEVGI SNMLPVVTSS IPQASTPSIH VLEPGESAEF
SASLTDPISI SASKRAVNSL ILSEFLQELS GWMETVSGVQ AIPVMQLFYR LSSAIGGAFM
DSSKPEEISL DKLIKWLLGE INLSKPFAAS TRSSLGEIVI LVFMFFTLML RSWHQPGSDG
SSSKLGGSTD VHDRRIVQSS TVVATQSSLH VQERDDFASQ LVRACSCLRN QEFVNYLMNI
LQQLVHVFKS RAANVEARGS SSGSGCGAML TVRRDLPAGN YSPFFSDSYA KAHRADIFVD
YHRLLLENVF RLVYTLVRPE KQEKMGEKEK VYRNASSKDL KLDGFQDVLC SYINNPHTAF
VRRYARRLFL HLCGSKTQYY SVRDSWQFSN EVKNLYKHVE KSGGFENNVS YERSVKIVKS
LSTIAEVAVA RPRNWQKYCL RHGDFLSFLL NGVFHFAEES VIQTLKLLNL AFYQGKDVSS
SVQKAEATEV VTGSNRSGSQ SVDSKKKKKG EDGHDSGLEK LYVDMEGVVD IFSANCGDLL
RQFIDFFLLE WNSSSVRTEA KSVIYGLWHH GRHSFKESLL AALLQKVRYL PAYGQNIVEY
TELVSLLLDK APENNSKQAI NELVDRCLNP DVIRCFFETL HSQNELIANH PNSRIYSTLG
NLVEFDGYYL ESEPCVACSS PDVPYSKMKL ESLKSETKFT DNRIIVKCTG SYTIQSVTMN
VHDARKSKSV KVLNLYYNNR PVSDLSELKN NWSLWKRAKS CHLSFNQTEL KVEFPIPITA
CNFMIELDSF YENLQALSLE PLQCPRCSRP VTDKHGICSN CHENAYQCRQ CRNINYENLD
SFLCNECGYS KYGRFEFNFM AKPSFIFDNM ENDEDMKKGL AAIESESENA HKRYQQLLGF
KKPLLKIVSS IGETEMDSQH KDTVQQMMAS LPGPSCKINR KIALLGVLYG EKCKAAFDSV
SKSVQTLQGL RRVLMSYLHQ KNSNFSSGAS RCVVSKTPNN CYGCATTFVT QCLEILQVLS
KHPRSRKQLV AAGILSELFE NNIHQGPKTA RAQARAALST FSEGDLSAVN ELNNLVQKKI
MYCLEHHRSM DIALATREEM LLLSEVCSLT DEFWESRLRL VFQLLFSSIK LGAKHPAISE
HIILPCLKII SVACTPPKPD TAEKEQTMGK SAPAVQEKDE NAAGVIKYSS ESEENNLNVS
QKTRDIQLVS YLEWEKGASY LDFVRRQYKA SQSIRGASQK SRTHRSDFLA LKYTLRWKRR
SSRTSKGGLQ AFELGSWVTE LILSACSQSI RSEMCTLISL LAAQSSPRRY RLINLLIGLL
PATLAAGESS AEYFELLFKM IETQDALLFL TVRGCLTTIC KLISQEVGNI ESLERSLQID
ISQGFTLHKL LELLGKFLEV PNIRSRFMRD NLLSHVLEAL IVIRGLIVQK TKLINDCNRR
LKDLLDGLLL ESSENKRQFI RACVSGLQTH AEENKGRTCL FILEQLCNLI CPSKPEAVYM
LILNKSHTQE EFIRGSMTKN PYSSAEIGPL MRDVKNKICQ QLDLLGLLED DYGMELLVAG
NIISLDLSIA QVYELVWKKS NQSSTSLTNS ALLASNAAPS RDCPPMTVTY RLQGLDGEAT
EPMIKELEED REESQDPEIE FAIAGAVREY GGLEILLDMI KSLQDDFKSN QEEMVAVLDL
LNHCCKIREN RRALLRLGAL SLLLETARRA FSVDAMEPAE GILLIVESLT LEANESDSIS
AAQSALTVSN EETGTWEQAK KIVLMFLERL SHPSGLKKSN KQQRNTEMVA RILPYLTYGE
PAAMEALIEH FSPYLQNWSE FDQLQQRHEE DPKDDSIAQQ AAKQRFTVEN FVRVSESLKT
SSCGERLKDI VLENGIIAVA VKHIKEIFAI TGQTGFKSSK EWLLALKLPS VPLILSMLRG
LSMGHLPTQT CIDEGGILTL LHALEGVSGE NDIGARAENL LDTLADKEGK GDGFLGEKVR
ALRDATKDEM RRRALRKREE LLQGLGMRQE LSSDGGERIV VSQPILEGFE DVEEEEDGLA
CMVCREGYKL RPSDLLGVYS YSKRVNLGVG NSGSARGECV YTTVSYFNII HFQCHQEAKR
ADAALKNPKK EWEGAMLRNN ESLCNSLFPV KGPSVPLAQY LRYVDQYWDN LNALGRADGS
RLRLLTYDIV LMLARFATGA SFSADCRGGG RDSNSRFLPF MFQMARHLLD QGGPVQRTNM
ARSVSSYISS SSTSTATAPS SDSRPLTPGS QLSSTGTEET VQFMMVNSLL SESYESWLQH
RRVFLQRGIY HTFMQHAHGR VASRAAEPTS SGGKTQDAET LTGDELLSIV KPMLVYTGMI
EQLQQLFKPK KPVHIEPIKK EGTSSGVELE PWEIVMKEKL LNVKEMIGFS KELISWLDEI
NSATDLQEAF DIVGVLADVL SEGVTQCDQF VRSAIDKD
//