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Database: UniProt
Entry: A0A1J0GDL8_9CLOT
LinkDB: A0A1J0GDL8_9CLOT
Original site: A0A1J0GDL8_9CLOT 
ID   A0A1J0GDL8_9CLOT        Unreviewed;       342 AA.
AC   A0A1J0GDL8;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=A7L45_02940 {ECO:0000313|EMBL:APC39096.1};
OS   Clostridium estertheticum subsp. estertheticum.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1552 {ECO:0000313|EMBL:APC39096.1, ECO:0000313|Proteomes:UP000182569};
RN   [1] {ECO:0000313|Proteomes:UP000182569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 8809 {ECO:0000313|Proteomes:UP000182569};
RX   PubMed=27891116;
RA   Yu Z., Gunn L., Brennan E., Reid R., Wall P.G., Gaora O.P., Hurley D.,
RA   Bolton D., Fanning S.;
RT   "Complete Genome Sequence of Clostridium estertheticum DSM 8809, a
RT   Microbe Identified in Spoiled Vacuum Packed Beef.";
RL   Front. Microbiol. 7:1764-1764(2016).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP015756; APC39096.1; -; Genomic_DNA.
DR   RefSeq; WP_071611392.1; NZ_CP015756.1.
DR   KEGG; ceu:A7L45_02940; -.
DR   KO; K01626; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; GCF_001877035:G1FCV-589-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000182569; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000182569};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182569};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       37    334       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   342 AA;  38632 MW;  D3548D944B55746D CRC64;
     MNIKYIKKMP TEKEIMEEMP LPNNIKEIKK NRDAEIRKVF ENESDKFLLI VGPCSADNED
     SVCEYIGKLA EVQEKVKDSI IIIPRIYTNK PRTTGEGYKG MASQPDPSKE PDMDAGLRAI
     RKLHIKALSE YHMPAADEML YPENYTYLSD LLGYIAVGAR SVENQQHRFT VSGVDMPVGM
     KNPTGGDLSV MLNSIKAAQD GHTFIYSGWQ VETSGNSLAH AVLRGAVDSY GKNIPNYHYE
     DLINIAKEYE KQKFANPSII VDTNHANSMK LYKEQPRIAR EVLMSRKDDS LLKKMIKGFM
     IESYIVEGKQ DVGRGTYGKS ITDACLGWEE TEKLIYNIAE NL
//
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