ID A0A1J0LHP1_9FLAO Unreviewed; 559 AA.
AC A0A1J0LHP1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000256|HAMAP-Rule:MF_01543};
DE EC=6.3.4.3 {ECO:0000256|HAMAP-Rule:MF_01543};
DE AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000256|HAMAP-Rule:MF_01543};
DE Short=FHS {ECO:0000256|HAMAP-Rule:MF_01543};
DE Short=FTHFS {ECO:0000256|HAMAP-Rule:MF_01543};
GN Name=fhs {ECO:0000256|HAMAP-Rule:MF_01543,
GN ECO:0000313|EMBL:APD05720.1};
GN ORFNames=UJ101_00167 {ECO:0000313|EMBL:APD05720.1};
OS Flavobacteriaceae bacterium UJ101.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1150389 {ECO:0000313|EMBL:APD05720.1, ECO:0000313|Proteomes:UP000183895};
RN [1] {ECO:0000313|EMBL:APD05720.1, ECO:0000313|Proteomes:UP000183895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UJ101 {ECO:0000313|EMBL:APD05720.1,
RC ECO:0000313|Proteomes:UP000183895};
RA Oh H.-M., Yang J.-A., Yang S.-H., Kwon K.-K.;
RT "Complete Genome Sequence of Flavobacteriales bacterium UJ101.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC EC=6.3.4.3; Evidence={ECO:0000256|HAMAP-Rule:MF_01543};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|HAMAP-Rule:MF_01543}.
CC -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC {ECO:0000256|HAMAP-Rule:MF_01543}.
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DR EMBL; CP016269; APD05720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J0LHP1; -.
DR STRING; 1150389.UJ101_00167; -.
DR KEGG; fbu:UJ101_00167; -.
DR OrthoDB; 9761733at2; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000183895; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00477; FTHFS; 1.
DR Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01543; FTHFS; 1.
DR InterPro; IPR000559; Formate_THF_ligase.
DR InterPro; IPR020628; Formate_THF_ligase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01268; FTHFS; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00721; FTHFS_1; 1.
DR PROSITE; PS00722; FTHFS_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW Ligase {ECO:0000256|HAMAP-Rule:MF_01543, ECO:0000313|EMBL:APD05720.1};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01543};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW Rule:MF_01543}; Reference proteome {ECO:0000313|Proteomes:UP000183895}.
FT BINDING 67..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01543"
SQ SEQUENCE 559 AA; 60114 MW; 0255BF74A5B7AD0C CRC64;
MTKVKSDLEI ATAADIKPIH LIAKKIGITE DQLELYGKYK AKLPLDLIDE SKIKQNKLIL
VTALSPTPAG EGKTTTSIGL TEALNRIGKK ATVVLREPSL GPVFGMKGGA AGGGYSQVIP
MEDINLHFTG DFSAIEKANN LLSALIDNNI QSKTRNLGID PRTILWKRVM DMNDRALRNI
TIGLGGTANG IPRQDGFNIT PASEIMAILC LSNDIEDLKE RIGNILIGFK FDKTPVYAKD
LNGIGAMTLL LKDAIKPNLV QTLEGNPAIL HGGPFANIAQ GTNSIIATKM GLSLSEYVVT
EAGFGSDLGA EKFMNIKCRA GNLNPKTWVI VATIRALKYH GGVSLKELNE ENVEAVSNGF
KNLERHIENA KLYGVTPVIS INRFSADTEA EIAKVQELCA EMGVKALLSE GWAKGGEGCE
PLAKAVVEVV EKATHDFQPL YPLDKSLEEK IEMIAQKTYG AKDVAFSALA LRKLKQAVTI
GLGDLPICMA KTQKSFSDED KKIGKPEGFT INIRDVEIAS GAGFIIPIAG KMMRMPGLPA
TPAAEHMDID KDGVIKGLS
//