ID A0A1J0LRT0_THEBO Unreviewed; 602 AA.
AC A0A1J0LRT0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:APD08716.1};
GN ORFNames=A0O31_00510 {ECO:0000313|EMBL:APD08716.1};
OS Thermus brockianus.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=56956 {ECO:0000313|EMBL:APD08716.1, ECO:0000313|Proteomes:UP000182993};
RN [1] {ECO:0000313|Proteomes:UP000182993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE-1 {ECO:0000313|Proteomes:UP000182993};
RA Schaefers C., Blank S., Wiebusch S., Elleuche S., Antranikian G.;
RT "Whole genome sequencing of Thermus brockianus strain GE-1.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP016312; APD08716.1; -; Genomic_DNA.
DR RefSeq; WP_071676536.1; NZ_CP016312.1.
DR AlphaFoldDB; A0A1J0LRT0; -.
DR STRING; 56956.A0O31_00510; -.
DR KEGG; tbc:A0O31_00510; -.
DR Proteomes; UP000182993; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 14..88
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 197..232
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 249..468
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 602 AA; 68507 MW; 60D79E637FC4ACEE CRC64;
MGLVRLEDLP PLPEAPGVYL WKRGEEVLYV GKAKSLRARV RSYFHAEGKA RRIAQEATGL
DFIATRDEVE ALLLEANLIK AHRPPYNVLL KDDKHYPFLK LTREPFPTLL VVRRVEEDGA
KYYGPFPEAG ALRRIKTLID RLFPLRKNSG YPMRRRRYPC LNHSMGRCLA PCVGKADPEA
YREVVRQVEA VLEGKVDWLL ARLEAQMREA ARRLEFERAA EIRDQMEALK AFFATSQQAF
DPELGDLDFL GLARAGALAV VQLFQVRSGR ILGRISRVVE KEEATDEEIL WAFLRDHYLE
ASPLPPLVLL PFPLEDLSGL EALLRRRAGR RVEVRVPQRG EKARLLEFAE KNARLTLETE
LKARERRGDH PALKALQDLL ALSTRPFRME AYDISHLQGQ ARVFSLAVFE GGRPKRQEYR
RMRLRAGNDD YQAMEEGVYR RYTGSLKEMP LPDLLLIDGG LGQVRAAQRG LERAGLRIPL
VGLAKKEEVL VTPEGREIRL PLTHPALRLL IHLRDEAHQN GLKQHQKDRS RELFRVLEGI
PGIGEARRRL LLERYGGLKA LKEAPLEELA RLPGMNRKAA EALKAALGEL QADVEQKQTT
SA
//
