ID A0A1J0MGI2_9CAUD Unreviewed; 347 AA.
AC A0A1J0MGI2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:APD20034.1};
DE EC=2.1.1.45 {ECO:0000313|EMBL:APD20034.1};
OS Serratia phage vB-Sru-IME250.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Ackermannviridae; Taipeivirus; Taipeivirus IME250.
OX NCBI_TaxID=1852640 {ECO:0000313|EMBL:APD20034.1, ECO:0000313|Proteomes:UP000230444};
RN [1] {ECO:0000313|EMBL:APD20034.1, ECO:0000313|Proteomes:UP000230444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Xing S., Ma T., Zhang X., Huang Y., Mi Z., Sun Q., An X., Fan H., Wu S.,
RA Lin W., Tong Y.;
RT "Complete genome of the first virulent bacteriophage infecting the
RT opportunist pathogen Serratia rubidaea.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ANM47126.1, ECO:0000313|Proteomes:UP000231470}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28265773; DOI=10.1007/s00705-017-3300-x;
RA Xing S., Ma T., Zhang X., Huang Y., Mi Z., Sun Q., An X., Fan H., Wu S.,
RA Wei L., Tong Y.;
RT "First complete genome sequence of a virulent bacteriophage infecting the
RT opportunistic pathogen Serratia rubidaea.";
RL Arch. Virol. 162:2021-2028(2017).
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KX147096; ANM47126.1; -; Genomic_DNA.
DR EMBL; KY073123; APD20034.1; -; Genomic_DNA.
DR OrthoDB; 5266at10239; -.
DR Proteomes; UP000230444; Genome.
DR Proteomes; UP000231470; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:APD20034.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:APD20034.1}.
FT DOMAIN 65..232
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 347 AA; 39203 MW; 06893B233DCC0AD2 CRC64;
MEIFALNNND MLKKAVLAIR EHGIESDPGN AEINTDGTRF LDGVTITVSD IRDRWLSVEG
RNSSALAAIG ETFWVLSGRN DIRFLSRVLP RAANFSDDGV TWRGAYGPRL YNNDQLDSVI
NRLRKNPNTR QAYLTIYDPT LDSDVNIAAQ REDRQPVTKD MICNLALLFS ITDGCLNMTV
INRSQDVLWG MSSINFIEFS IIQEVIANVL GVNVGQYKLF SNNLHYYNNE VSRKQLGGIT
WKTQTSTGGL VCSLLSFNRD KVKNQNDIRN LFLGVLHHCD IGSDFGKVRE HLVQFDADRG
LMLDMAYCLW CRLNDSKIYK HCVSDDGLRA ALLHSPVDRK YVWGQGE
//
