ID A0A1J0VG16_9GAMM Unreviewed; 271 AA.
AC A0A1J0VG16;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:APE30961.1};
GN ORFNames=BOX17_08350 {ECO:0000313|EMBL:APE30961.1};
OS Halomonas aestuarii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1897729 {ECO:0000313|EMBL:APE30961.1, ECO:0000313|Proteomes:UP000181985};
RN [1] {ECO:0000313|Proteomes:UP000181985}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hb3 {ECO:0000313|Proteomes:UP000181985};
RA Koh H.-W., Rani S., Park S.-J.;
RT "Halolamina sediminis sp. nov., an extremely halophilic archaeon isolated
RT from solar salt.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-
CC amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP;
CC Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841,
CC ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000565};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-
CC methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+);
CC Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216;
CC EC=2.7.1.49; Evidence={ECO:0000256|ARBA:ARBA00000151};
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
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DR EMBL; CP018139; APE30961.1; -; Genomic_DNA.
DR RefSeq; WP_071943546.1; NZ_CP018139.1.
DR AlphaFoldDB; A0A1J0VG16; -.
DR KEGG; hsi:BOX17_08350; -.
DR OrthoDB; 9810880at2; -.
DR UniPathway; UPA00060; UER00138.
DR Proteomes; UP000181985; Chromosome.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:APE30961.1};
KW Transferase {ECO:0000313|EMBL:APE30961.1}.
FT DOMAIN 18..265
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 271 AA; 28218 MW; 0F25F1A1EBD121EC CRC64;
MMAHSRPIPN TLTIAGSDPG GGAGIQADLK TFSALGSYGT SVITALTAQN TRGVAGVHPV
PADFIAAQLD TLLDDIDIAA VKVGMVASRR VAEVIRDALG ARRPRWVVLD PVMVAKSGDT
LVDDAGIAAV RDCLVPLADL ITPNLPEAAV LLDCPVPHDR AGMEAMVPGL RALTPGAVLL
KGGHLRGETC PDLLVTGDNL TWLDGRRIAT GNLHGTGCTL SSAITARLAQ GDALPDAVTA
AKAWLSRALE ESHRLHVGQG HGPVHHFHAW W
//