ID A0A1J0W0Z2_9NOCA Unreviewed; 329 AA.
AC A0A1J0W0Z2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA {ECO:0000313|EMBL:APE37881.1};
GN ORFNames=BOX37_00065 {ECO:0000313|EMBL:APE37881.1};
OS Nocardia mangyaensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=2213200 {ECO:0000313|EMBL:APE37881.1, ECO:0000313|Proteomes:UP000183810};
RN [1] {ECO:0000313|EMBL:APE37881.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y48 {ECO:0000313|EMBL:APE37881.1};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP018082; APE37881.1; -; Genomic_DNA.
DR RefSeq; WP_071931046.1; NZ_CP018082.1.
DR AlphaFoldDB; A0A1J0W0Z2; -.
DR KEGG; nsl:BOX37_00065; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000183810; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:APE37881.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000183810};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 5..235
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 329 AA; 35264 MW; 38C182EC4820CBB7 CRC64;
MPDAIVAEGL VKRYGRVTAL DGLDLSVPEG TVTALLGPNG AGKTTTVRVL TTLLVPDEGR
ATVAGVDVLN DPQTLRSRIG ASGQYSAVDE YLTGFENLEM VGRLYHLGIK RSKERARELL
ERFRLADAAD RPVKGYSGGM RRRLDLAGAL VANPPVLFLD EPTTGLDPRA RLDLWDVIEE
LVAGGTTLLL TTQYMDEADR LADAIGVIDH GKVIARGTAD ELKTLVGGDR IELTVADVDE
LATAQQVLGG LADGEIHVEP ALRRLVVPVA DGSQDLVTAI GRLTEHKVKI NDVALRRPSL
DDVFLTLTGH EAEELVNGDA ELAKEGQSR
//
