ID A0A1J0Z4E7_SPICI Unreviewed; 349 AA.
AC A0A1J0Z4E7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Cell shape-determining protein MreB {ECO:0000256|HAMAP-Rule:MF_02207};
GN Name=mreB2 {ECO:0000313|EMBL:APE75773.1};
GN Synonyms=mreB {ECO:0000256|HAMAP-Rule:MF_02207,
GN ECO:0000313|EMBL:QIA73758.1};
GN ORFNames=GL982_09575 {ECO:0000313|EMBL:QIA73758.1}, HHA36_09575
GN {ECO:0000313|EMBL:QJU62461.1}, SCITRI_001910
GN {ECO:0000313|EMBL:APE75773.1};
OS Spiroplasma citri.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=2133 {ECO:0000313|EMBL:APE75773.1, ECO:0000313|Proteomes:UP000183717};
RN [1] {ECO:0000313|EMBL:APE75773.1, ECO:0000313|Proteomes:UP000183717}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R8-A2 {ECO:0000313|EMBL:APE75773.1,
RC ECO:0000313|Proteomes:UP000183717};
RA Davis R.E., Shao J., Gasparich G., Gaynor B., Donofrio N.;
RT "Complete Genome Sequence of Spiroplasma citri R8A2.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QIA73758.1, ECO:0000313|Proteomes:UP000464221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BLH-13 {ECO:0000313|EMBL:QIA73758.1,
RC ECO:0000313|Proteomes:UP000464221};
RA Yokomi R., Chen J., Rattner R., Selvaraj V., Maheshwari Y., Osman F.,
RA Vidalakis G.;
RT "Whole genome sequencing and comparative genomics analyses of six strains
RT of Spiroplasma citri.";
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QJU62461.1, ECO:0000313|Proteomes:UP000501133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 {ECO:0000313|EMBL:QJU62461.1,
RC ECO:0000313|Proteomes:UP000501133};
RA Rattner R., Dang T., Mello A.F.S., Espindola A.S., Cardwell K.,
RA Fletcher J., Yokomi R., Vidalakis G.;
RT "Genome-wide analyses of Spiroplamsa citri strains and comparison with
RT other spiroplasmas.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms membrane-associated dynamic filaments that are
CC essential for cell shape determination. Acts by regulating cell wall
CC synthesis and cell elongation, and thus cell shape. A feedback loop
CC between cell geometry and MreB localization may maintain elongated cell
CC shape by targeting cell wall growth to regions of negative cell wall
CC curvature. {ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- SUBUNIT: Forms polymers. {ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02207}.
CC Note=Membrane-associated. {ECO:0000256|HAMAP-Rule:MF_02207}.
CC -!- SIMILARITY: Belongs to the FtsA/MreB family.
CC {ECO:0000256|ARBA:ARBA00023458, ECO:0000256|HAMAP-Rule:MF_02207}.
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DR EMBL; CP013197; APE75773.1; -; Genomic_DNA.
DR EMBL; CP047428; QIA73758.1; -; Genomic_DNA.
DR EMBL; CP053304; QJU62461.1; -; Genomic_DNA.
DR RefSeq; WP_071938026.1; NZ_CP053304.1.
DR AlphaFoldDB; A0A1J0Z4E7; -.
DR STRING; 2133.SCITRI_001910; -.
DR GeneID; 54239717; -.
DR KEGG; sck:SCITRI_001910; -.
DR OrthoDB; 391604at2; -.
DR Proteomes; UP000183717; Chromosome.
DR Proteomes; UP000464221; Chromosome.
DR Proteomes; UP000501133; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR CDD; cd10225; MreB_like; 1.
DR Gene3D; 3.30.420.40; -; 3.
DR HAMAP; MF_02207; MreB; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR004753; MreB.
DR PANTHER; PTHR42749; CELL SHAPE-DETERMINING PROTEIN MREB; 1.
DR PANTHER; PTHR42749:SF1; CELL SHAPE-DETERMINING PROTEIN MREB; 1.
DR Pfam; PF06723; MreB_Mbl; 1.
DR PRINTS; PR01652; SHAPEPROTEIN.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_02207};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960, ECO:0000256|HAMAP-
KW Rule:MF_02207}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02207};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_02207}.
FT BINDING 19..21
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207"
FT BINDING 163..165
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207"
FT BINDING 211..214
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207"
FT BINDING 291..294
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207"
SQ SEQUENCE 349 AA; 37824 MW; C6CD254192CD56CF CRC64;
MANYKFGKDY SFLTLDLGTA NTVAYVSGQG IVYNEPSMMA YDTLNNSLIT LGNEAYKMVG
KTHDHIRMVT PLVDGVISDM EAAQDLLKHI FSRLKLSGIW KNSLVILACP SGVTELERGA
LKAIAKDMGA SHVLVEEEVK LAALGAGINI GLAQGNLVID IGGGTTDIAI ISAGDIVISK
SVKVAGKQLD QEIQKYIRVE YNVLVGIRTA EQIKKEIGAL VKIINEKPVR AFGRDIITGL
PREILIKPEE IKNVLLASFS RITDLLVEVL EQTPPELAGD VIRNGITICG GGALIRGIVK
YFESIFQLKV KAANDPLMCV IEGAKTYEKN LGAVIERIQL LDANEYKIS
//
