ID A0A1J1AAX7_9EURY Unreviewed; 439 AA.
AC A0A1J1AAX7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134};
DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134};
GN Name=gcvP1 {ECO:0000313|EMBL:APE94952.1};
GN ORFNames=HSR6_0489 {ECO:0000313|EMBL:APE94952.1};
OS Halodesulfurarchaeum formicicum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halodesulfurarchaeum.
OX NCBI_TaxID=1873524 {ECO:0000313|EMBL:APE94952.1, ECO:0000313|Proteomes:UP000186165};
RN [1] {ECO:0000313|Proteomes:UP000186165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HSR6 {ECO:0000313|Proteomes:UP000186165};
RA Sorokin D.Y., Kublanov I.V., Roman P., Sinninghe Damste J.S.,
RA Golyshin P.N., Rojo D., Ciordia S., Mena Md.C., Ferrer M., Smedile F.,
RA Messina E., La Cono V., Yakimov M.M.;
RT "Discovery of first anaerobic lithoheterotrophic haloarchae widely
RT represented in hypersaline habitats.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
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DR EMBL; CP016804; APE94952.1; -; Genomic_DNA.
DR RefSeq; WP_071932694.1; NZ_CP016804.1.
DR AlphaFoldDB; A0A1J1AAX7; -.
DR GeneID; 30417013; -.
DR KEGG; hhsr:HSR6_0489; -.
DR OrthoDB; 17655at2157; -.
DR Proteomes; UP000186165; Chromosome.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR CDD; cd00613; GDC-P; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR023010; GcvPA.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR42806; GLYCINE CLEAVAGE SYSTEM P-PROTEIN; 1.
DR PANTHER; PTHR42806:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING); 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:APE94952.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186165}.
FT DOMAIN 6..432
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
SQ SEQUENCE 439 AA; 47765 MW; ED391320B56086FF CRC64;
MSGSPYAPNT ETDTSEMLDA VGVSDVEELF DIPEPVRFDG EFDIESRSEP AVLNMVSDML
GNNDDMTEFL GRGYYDHYVP SVVDRLSLRS EFLTSYTQYQ PEVTQGFLQA LFEYQSILVE
LTGLPVANAS MYDAASGLAE AALLASRIRD ADGTDVLVPE YVREERVSVL ENYVAGHDIH
VKRVGTADGT LDIDALTAAV DEDTLMVYAE SPTTRGTIEE HLAEIGEIAH ENDAMFTVAS
DPVAMSILEA PGDLGADVVV GDAVLGMPNA YGMGLGIFAT RDDYLRHVPG RLIGIGEDQD
GKRAFTLTLQ TREQHIRRER ATSNICTNQA WVALRTAIHA ASLGPDGLVD LAEQMVELPR
DLAAQLDALP GIEAPIHDRH HFREFVARTE APASEIVAAL EDEGFAVQAV DDHELQFTVT
ETNEHAVDDL IAAVEEVVA
//
