ID   A0A1J1HBP0_PLARL        Unreviewed;       481 AA.
AC   A0A1J1HBP0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=PRELSG_1456100 {ECO:0000313|EMBL:CRH02827.1};
OS   Plasmodium relictum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Haemamoeba).
OX   NCBI_TaxID=85471 {ECO:0000313|EMBL:CRH02827.1, ECO:0000313|Proteomes:UP000220158};
RN   [1] {ECO:0000313|EMBL:CRH02827.1, ECO:0000313|Proteomes:UP000220158}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SGS1 {ECO:0000313|EMBL:CRH02827.1,
RC   ECO:0000313|Proteomes:UP000220158};
RG   Pathogen Informatics;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LN835309; CRH02827.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J1HBP0; -.
DR   VEuPathDB; PlasmoDB:PRELSG_1456100; -.
DR   OMA; HLKQLYM; -.
DR   OrthoDB; 3639304at2759; -.
DR   Proteomes; UP000220158; Chromosome 14.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CRH02827.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000220158};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        223..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          141..464
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
FT   COILED          357..384
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   481 AA;  56580 MW;  68DCF8B5A390FD1E CRC64;
     MAKLIKRGSI FDTLFFFKNI CYQKKKELSK FFIYPKKYKS AIDKLNTNLY FATKKKIEVL
     NQEKNSIHQI VKYNISNQKM CNTFIKNIKN KSNTNKTDSN INNQNKNEEK KNLVDIIDLE
     LSDIWSKKTL IVNYKNNIFE IILNRPDKLN AINKDMITGL LNMIKSLDND NRCYMIVIRS
     INTKCFSSGS DVRAIIENKE DGILYLRQLY LYINYISKMK KNLLCIWNGF VMGGGLGISI
     YSKYLAIHKN AIFAMPENKI GFFPDIGCCY FFKKYFGRSI GLHLGLTSLR INEADLAKFK
     VCNTYIENID LFLDELKNIN KCNQMDFNIE YNRILSKYSL KNCSTTPILT DELISNINKY
     YDSSNNLEEL ISNLKKDNND FCKQLLSDIN NNCYFSCKLW FSYFHYNYDK SLEDILDNDF
     KISQYILYYT KTFEKGVTEI LVKKNKNFQW SNVEENKSVQ LENIEDIIMN KNLLSIKEEF
     I
//