ID A0A1J1HEH5_9DIPT Unreviewed; 857 AA.
AC A0A1J1HEH5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=CLUMA_CG000057, isoform A {ECO:0000313|EMBL:CRK86397.1};
GN ORFNames=CLUMA_CG000057 {ECO:0000313|EMBL:CRK86397.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK86397.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRK86397.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CVRI01000001; CRK86397.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J1HEH5; -.
DR STRING; 568069.A0A1J1HEH5; -.
DR OrthoDB; 3015258at2759; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 2.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 2.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF943; NICOTINIC ACETYLCHOLINE RECEPTOR BETA 3 (DBETA3) SUBUNIT; 1.
DR Pfam; PF02931; Neur_chan_LBD; 2.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 2.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..219
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 227..356
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT DOMAIN 449..646
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 676..777
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 351..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 98491 MW; 08603F5B1F39D10D CRC64;
MSRFIIKALW NDTDVDRLRH ELLKDYDINA RPENNGDVTN CTVELSLINL EMDEERGVML
SHIWIHLNWT DNKLKWDNDK YPGIKSVHVA ADEVWQPDLM VYNSAEVRLV EHFAKTNKIV
YSHGSVLWVP PGKFETYCNL NLKFWPFDVQ KCDIKIGSWT YNGYQLDLKL LKDHVNTAHY
TTNQEWEVLD STAVRNSKIY PCCAEPYIDT TFTLVLKRKS PMFKSLVIIP ALAVACMMLV
TFWLPPQSTE KLLLNGIAAV LTCMMLLYFS KLFTVLSSSP PLIVMFYFHS LLMLCISLII
SVIVVNMSRN PKNYAVPLSL RKNISDGILG KIFGPKKALA EESETQISEL KETPFEEQRN
SSDHKVIDLP PNPEQKDTQN DWTRVAIIID HEHQNLVTIE HQTRALGIFR SHEIFDSAIN
RAFMFSGMLV RKNSIELYFY TSTATDVDKL KHDLLKNYDP TVRPENFKDT TLVTVGLTLQ
DVEIDESRGA MISHVWGNFD WNDSKLIWDK ELYNNVTSLI VPIEQIWHPD IYVYNSMNSD
LRNQFYQTHK VVTNGSVLWV PPAKLESYCN LNLKFWPFDT HTCKIKMGSW TSSGYHIDLK
AKDSTVDTSD FNGVFGWDVL KTKVTRNEIF YSCCPEPYVD ISMIVEFYKV KNINKSYFAA
FTITLQRRSP IFKSVVIIPA LAVICMMMVS FWLPPQSTEK LLLNGIAAVL TCIMLLYFSK
LFNALSSSPP IIVMFYSCTL LMLCFSLIIS VIVVNISRNP KRSAVPYTVK SILLDGFIAK
AFGVFDSNQM KTENNLGEIK QNSLDKIQED HKVMELVTET KNDDIQNDWI RLAIVVDRAV
FLAYVLIFIG VIFLHFI
//
