ID A0A1J1HF33_PLARL Unreviewed; 870 AA.
AC A0A1J1HF33;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=DHHC4 {ECO:0000313|EMBL:CRH02477.1};
GN ORFNames=PRELSG_1420500 {ECO:0000313|EMBL:CRH02477.1};
OS Plasmodium relictum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Haemamoeba).
OX NCBI_TaxID=85471 {ECO:0000313|EMBL:CRH02477.1, ECO:0000313|Proteomes:UP000220158};
RN [1] {ECO:0000313|EMBL:CRH02477.1, ECO:0000313|Proteomes:UP000220158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SGS1 {ECO:0000313|EMBL:CRH02477.1,
RC ECO:0000313|Proteomes:UP000220158};
RG Pathogen Informatics;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN835309; CRH02477.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J1HF33; -.
DR VEuPathDB; PlasmoDB:PRELSG_1420500; -.
DR OMA; ETKINCF; -.
DR OrthoDB; 276762at2759; -.
DR Proteomes; UP000220158; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR22883:SF438; PROTEIN S-ACYLTRANSFERASE 7-RELATED; 1.
DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000220158};
KW Transferase {ECO:0000256|RuleBase:RU079119, ECO:0000313|EMBL:CRH02477.1};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 34..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 236..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 847..865
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 134..269
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 331..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 103351 MW; 04E50BED5290765B CRC64;
MKILKRSKSL ERQNFDKINN VQIYGENQIH CKGFFISGPA FLTVISSFLM IFIPVGIFHA
FTSTWFFEKG IYFVTFLNLF FFVLTIYSFF KTSFMDPGII PRQKSVLNLY DVIIEQYRET
QPPRQKEVLI NGHFYKLKYC YTCNIYRGLR TVHCSICDNC VEKFDHHCPW VGNCIGARNY
KYFVFFVLNL YILICITLSA SIYKLVICIN KLSGDGYNTE KIFIHIWRVA ADSLILIIYT
VLTLWFVIGL LCYHIYTILT NQTTYEQIKT FYQNDNPFNI GIVNNIKEVL FTKTRPSYIN
FVNPQLQVVD KNCYHNIIVF NDKGVNIEED IREKSSSDNR KKDKKKMDSM EIRSINKKSS
KKKKSSKDCI PPSHGSKIRI KSYNIKKKIN KEKISEEYDI TKISNISNKA IEKSAHLKFD
KNKNIKYTKI KLPKIKNDDS EHLNEDVEEK NVSSHKRIIN LNNVGALFIK NNSSSSISTK
NGNNKEMKKK RRDNYVDNEI DNEFYDYQEE LIDIEKRMLK KDDYIVIKNT NEKNGEYSNK
MKKKQKKKIL YKTKESKQIR KKKIKYETKI NCFNSSIQVR KKRNFPILNK KRFSFIGNLK
NKSEIYYIVS YCNEKKKKSS INSEKEFKKK ENIDEDKIFF KEYNRSTKKK EKMKLKENKR
EEDIQKNVII DIYNNMPDER KTKINNEIIL EIPKKKEYES NTSLEEIEKR KKTNYIKYDR
LYLVGKGCKL ENFSEIYEMK YAKMHNLKYK KINKKLKKNK LKLLSKSHIN IHLFYNNKEC
TNVSNNINGN IDTLGKYESC NFNNIYFSKI KNINKIDNLK LLNYLVHKNK QNEIRSDMKK
KSKVSKFFYF FTTFALIIKC IHIPSNNDND
//
