ID A0A1J1HFA6_PLARL Unreviewed; 4909 AA.
AC A0A1J1HFA6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 03-MAY-2023, entry version 25.
DE RecName: Full=separase {ECO:0000256|ARBA:ARBA00012489};
DE EC=3.4.22.49 {ECO:0000256|ARBA:ARBA00012489};
GN ORFNames=PRELSG_1428000 {ECO:0000313|EMBL:CRH02549.1};
OS Plasmodium relictum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Haemamoeba).
OX NCBI_TaxID=85471 {ECO:0000313|EMBL:CRH02549.1, ECO:0000313|Proteomes:UP000220158};
RN [1] {ECO:0000313|EMBL:CRH02549.1, ECO:0000313|Proteomes:UP000220158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SGS1 {ECO:0000313|EMBL:CRH02549.1,
RC ECO:0000313|Proteomes:UP000220158};
RG Pathogen Informatics;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=All bonds known to be hydrolyzed by this endopeptidase have
CC arginine in P1 and an acidic residue in P4. P6 is often occupied by
CC an acidic residue or by a hydroxy-amino-acid residue, the
CC phosphorylation of which enhances cleavage.; EC=3.4.22.49;
CC Evidence={ECO:0000256|ARBA:ARBA00000451};
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DR EMBL; LN835309; CRH02549.1; -; Genomic_DNA.
DR VEuPathDB; PlasmoDB:PRELSG_1428000; -.
DR OMA; MCEILHE; -.
DR OrthoDB; 5479815at2759; -.
DR Proteomes; UP000220158; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0098813; P:nuclear chromosome segregation; IEA:UniProt.
DR GO; GO:0000280; P:nuclear division; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005314; Peptidase_C50.
DR InterPro; IPR030397; SEPARIN_core_dom.
DR PANTHER; PTHR12792; EXTRA SPINDLE POLES 1-RELATED; 1.
DR PANTHER; PTHR12792:SF0; SEPARIN; 1.
DR Pfam; PF03568; Peptidase_C50; 2.
DR PROSITE; PS51700; SEPARIN; 1.
PE 4: Predicted;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000220158};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1442..1461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1467..1483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1913..1930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2171..2189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2382..2402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4526..4645
FT /note="Peptidase C50"
FT /evidence="ECO:0000259|PROSITE:PS51700"
FT REGION 776..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2833..2860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4307..4334
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 779..805
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4909 AA; 592827 MW; E0C1C2061B0C6FC5 CRC64;
MISRELNIYE KLDKILSDVL RKIDEEFKNL GEKQNEHIYR KFYELFNKES YIEKLNHNDL
IKTYKDKNIH KYLFYMFESL LNKIILTKNL NYVDFLFLIL RYITYMWVFL SKDDKLVLIF
YYYFKFVDLL FNIKFIKCSF LINIYNILIY FYIKGNKKIV FTVKNLNEKE VSSYIKDVIL
ELNKIIINEN SNFIKSFEKE SFIDFQNDIS EKFHKINSTN IEDVGSMNYY NLYNYIWMCY
YEDNNIFEEK KGDNEEPNKK KKSGNEKNFS LILKYVNNRN IENILGLNFF SIKSSYNMFI
NFVKNLFKIT FYDFNIFFFF LNLLNLEFFF IYFHIFEILF YIRTIENKKE EIKKTKIISF
DTNINNSVSP KLTKKMDNLQ NKEDNFNECI FLNNKNNKKI LWSIMFDELR KNFIADTKNV
NYTLKVLKFT FNFFLFDEHF FLKNNLSENF VIKKEYNFSF ISPIYLKELL KFNLSYLCNL
MNSRNLNDEI VFKATSYVFY LLSKLICNVN NNIKKFILLN NDNNLSFISL ISYIHKYFKK
LYIDKNTDEV LQNGKEDNNI NSTYKLKYSF TTLEKLYKKI QECLYVVLTI DDFVENYIKK
FINSDNNCAN NYDLYTCVII KINKINMFYS NLDIIKILSD KDKSIFRKYI YTINKNHENF
ISLFSFLLNI DFKENENELI LKKYILDLKK KNYKSKKLIK LMKPYHSPLK YIILKNEIHE
SNIKKNSLKR NEKEAKLYQS NYGYFIENNE SEKLNDKKKI DKYQLDNNIE KENGIYEEAN
DSSCEDSDTD EDDDGDDDES DDKYTDDDER SDKFNCENKE YIKLKEGKIN TMKKKKKDMP
IFENSFFYIN KNFKKINIDL KIFCHNIILS AKRCILISES LLDYFKKNKE YEVNFNIFVC
KSIFVNFLKV SLLNISLFSY ICSKLKFDDV LKLIYDSNLV ILAYNIFDKY VSFVLDQNIE
KLNQYRNNFH FSTKKLNKKE KFSNKSDEKS FIYYHLYLDD IYEILSDKEH KSNFFLSDNN
EFIETLYLNT FLITINIISV WEIYLEIPLE VLNKMKYTFF ELFYNTTIKI VKFIKKDKSF
FFLLNILKFI YTKFISLPFN PINIHTTIKL HDFYEFLINE NYTDLKKEDK FSNDNIYLNS
VSPLKLLSNK IDEMPDKDKD INNFNHTNVL SINKKKRVSI GGLIPVFLNN ENVKKRKTNI
DYISYNSIDK ENSSNFTWKK NICNDDLLKN VNENNNIKYN FYENVNETPK QNYNMINLPS
KDNVDKDNKN KDINKFRNTY LSNYYIPHID LLFIILDLEV FYYFEKKNYK KIIVIVENIL
NKIINKCDYN TKEYLRSSIS YIYNYYQQIY ITNNKINIQS CTVIRHIFNL YVKSKVFHLS
KKIKKYIFNC KKNYTNNDLL KSNYNKIYNN FLNDDKWKYF FYFNKVVSIN HGKERKEQKK
KIIIDNLLVI HINTLLFLIF YEYLSKYITK NFIFFFRFFF FLFNKLCIDI LRLVNESNHL
EFFNIFDYIN NSNDEKGEVI EKLKKQLCRS NNLMDINNNK LIHSKKNIKK SINKQIIIID
IEELLVTYIQ INFIFCRSCC FLTFFKNVCS QKYEIILKEN ITNNYFEKFK NNRYFFDFFD
FKKEEKKSNE KIDDENVGNE RLENIYDIKD KKINTSYDEN SDEKYESDTS SINVSQSSFT
LIEYTDYSNN LDYIFLEFIL EKIEEMDVDH YYKNVLKNCY YVIKIEMFYN FIYNNVETLK
RFLYLNNVYY LYKLYYHIFV WNNKICKKKD ITSKTKIYNN LYTNSSIYNN IFDVFPLNDI
LREKLNINYI KLKCYDTCSF DINPGNIDSQ NLATQYNNEN VINNIKNNIF QDNYIENDFF
LCNIYNFNLK LFHPLNIENN LNKEKQNIYN SLLIINKNYL INLKMKYNKI NKYINNYMLS
IYYIVLFFYF NEYIEKNKLS FYYIIYIFQK KFDTFNSNIC NISFLNEKMK SSEKKNYNSF
KIYKQNHLKR NIFLIFEILN NIYDIYYNNV FENPNLCNEI VIKIDVKLIG YLSEIYKIAF
LYKNFHHCIH ILILCVMFTS KFWSIFIFNE KHEYKKFCGS SYKNNKEKEY KKTEKKKDEK
KDTFSYKVST NDINSKEKKK YIFNNVIKEK QDKYKQRKHR RTYILDIIYN KITSNVNENN
IKEIYNDLHN YMQTLIICVS IFYLAFLCME KVYKNKFNIL FLNSANNIYY YYLDFFEYIK
KFCEKYCADK LYLSNFFFDN YHLNLINLKF QAHVKAKIYK LKLEKSKKTN RNNVNKKIFY
KSTNDNMCNK NNIIIETKCI LRKNNNSDID YDNFIYSDNY YEQIHSNFSY LFYYNERVIK
DCINNLKKIE KKYENDHKNF FKNNICLYFN IIKYLYKKKT KYLSLLLFAN TYIIPIITFM
KFTMIKYFSY FNISSDFFSL KFEHPLYEFD IDMITKIKKT DDEKENLKIS NKVILMNLEN
LFCNMFLNKD IFYYIKFINL YYKKISKILY KVNNFLLSYY YLKKNVLFIC NLIYFPEIIH
NYFLLTNIIL TCGKERIELL TQEEIFFENL NDDLDIYEKK KFDNNEETPN KQKIKDIDDF
KIYEDDDFLN INYIETPLNT YLTKRNIYEY KNLLNRFFDY LNLIIGNIDN MDMLTTKYKK
EILHIYCLII LKKKQSHHFY SSIKKIQLKK ESATYENDTK IYENNKNKTT TDLINKINLN
KDLNLMGQIN LKDEINLKDN NTNVTNEHEI FDTENINYNE LNKDKNEKWN DQINYFGIEF
LTCFNNCNKK KKTFFNFLFE NLFLINNVDT DIFNISLNNE EKTTNIIKFF VLKDINNIKV
INYKNDCYIN NFIESNENLN EDGESKMKQY EDTSINIEEN EFLDYNNLNL CLSSFKLNDI
LVLNYLYLNY NFKDNLIYVR NYVNNRLFTY NCRRMNTYFI KILLYYINLM FLNIKNIFCD
DCIYTIKKQQ FLNSSANDCS RNIFFLLFLK VFNFFNFSKE TLIEICSNYF PGNKYHKYLE
FLSKNDEQKD DNIKIKNAFN ENHSYRGNSE NTINNILDFN NITFDNYDKI LFLNFVEIFL
FPSRDCSYFE VLTVCYEFLT NIKDGNSKII RKQKKKKMYF ILKIIIIEAE NEKKNYFFQT
ILIYLSLLLY NTHKKSFIYE MRRIAQFFLD FVFFFIENIK NNLIILQIIE SYANNLYIID
ENKRSNKFCF RKKKYFYLLK FYFRKLLSLL YLYTDELIPY TIKSSIDQEI SQKNYYRKNV
NKNLNIEIIY NYEYINQMDL SNFCFYWDYS IVSMSHDKSD LYISRCFKNF LLLLINLFKK
NEDNNLDKEI SLNEEGCLNK ENCYYFYEKT SNFFNILNNK EILEKFFDDD NIYMLKDNLI
DFLYDNKDNI KDNVNDKKKE IFKDSNCYLN FYKNKVHLNN NLLFEKKENY KNKNTKDENF
DSEYIHRKNE KINENNVLQN SFNLEKNKKK EILNNMNKDN IFFYFDSNNI SDNNNIKENV
GINLEMLHFF SSLYRNASNC INKKKYEYFH VDKIHLNIEK FTFKEKWNYI KKLERILKQY
QHMIKIMCEI LHESKNVDRN RSNLKKFIDL WWNNRYTLEQ HLKILNLDIS NNLGFSIHKL
ISAPLITLNI KKNNDCNENN NYSNDISKKN ITNEGNIKHV NKNICGIISP ANNQKYYLRS
NFDIFVVFFY YSNMLNIISW INKWKNFFLS IKYWDELNFI NILLNLSVFS IVIKNCNIQI
NQVKKKYLKF NHNIKKDNNY NNSMLVKKNS LDINKTATCY LPFFNKDIET ILTSEKKIEK
KRGRRYTYSE NVNLQKNDDE LDITNKPNCS IKEKNSVNKN YNNPLEDDEN STMSNINNQY
RITSPNIKEN IYLCNTNSNI KKIRKTTNII NNLNNSNIYD KDVINKNEKR QKKKDKKINS
TIYNYLSPLK VDDSESSRDK YGNVFLKNKK KRITVAGTLN VNEIKKDGGK KENNYLKYLD
LKKICDKGIL KCSFLKLRMY LYNILIDIFE NNQVHPKEIF NIFNNITHSF ITDIIKCNIL
VDESDKEKYI YVRSIESKRT RKNPIIIYIH NNLNRLPFEN LEPLKDSYIV RGVHKSVTSY
LYERLLRKIK KEEIQSNEDI FSNSSEGELT EKKYKDDGSE EFDMNEYIKQ EYCKKWKLPM
CKDNKETTLI YSYDLCESLE SKEKKRDMEI IVNRNENNTN EIDNLQYLKK KNISVSKNKA
DMFYELLNYQ EKNISKKDSS INHDNNIQIT VVDHKNNFDK LKTDNKNYDH CHSIYSIECN
NNEEKRKTKS NKSNKLNIHD IYNNSIYSSS SDLENKKELQ SKDIYNLIIT KDEKKDIKNE
KEICEKEKNS KKSRKSVCIE YSFINPFNNK NKKKSMNLPF NEKEFNNKDK IIKENENTVH
NNLKKVEIDK LKTCKLRKRS SVKSSYPSSS SSSSLSSVEF IQKEDELRKI FMNARKSMNI
HNIMGIYKKD SSDFCNFEKK RKKSVSESEA YFDKEKKLSS LVESCRKEKR RSYSTDVEHL
SKSSKKKYIK YIPYYINSSR LIDPKKSKIF FVINPNGDLK RTEDATYPFI YFKNKEKYKY
KNWNGFFGKV PCENILLKHL CNDDLYLYCG HQGGEQYIKK ENVQNAILSY DENLKKDKKE
ERSSKLKKNS EIDVSKGKEE NNCDLLSECN KKKRRNSCKF DTKKTIIEKR SKRKSLGNLN
DINNVNNLYS KNETDDFNLI LNKNDGINCC VFLIGCSSGL VSSHGFDLDV WGTPYDYIVG
GCIFIFGNLW NVTDGEVDGF TQNFFWKWTQ PNSSSLFHSN YNYVNNYVQM DMLRINFSLF
INLLKKNYQR EKELHNQNIE KNNLIIDISD NFVTLDIDTY KYFKKNNFFY EYFQNCYNCK
IILNQNIFNI NQNQKYLWLS MTEALVEARQ FCRLPHTTGS AVVIYGLPL
//
