ID A0A1J1HKE7_9DIPT Unreviewed; 2206 AA.
AC A0A1J1HKE7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=CLUMA_CG000755, isoform B {ECO:0000313|EMBL:CRK86934.1};
GN Name=putative Afadin {ECO:0000313|EMBL:CRK86934.1};
GN ORFNames=CLUMA_CG000755 {ECO:0000313|EMBL:CRK86934.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK86934.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRK86934.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CVRI01000002; CRK86934.1; -; Genomic_DNA.
DR STRING; 568069.A0A1J1HKE7; -.
DR OrthoDB; 2881454at2759; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0005911; C:cell-cell junction; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd15471; Myo5p-like_CBD_afadin; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01782; RA1_Afadin; 1.
DR CDD; cd01781; RA2_Afadin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR028842; Afadin.
DR InterPro; IPR037977; CBD_Afadin.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10398; AFADIN; 1.
DR PANTHER; PTHR10398:SF2; AFADIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 2.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832}.
FT DOMAIN 42..136
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 229..321
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 673..901
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 996..1081
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 140..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..1607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1739..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1836..1855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1895..1915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2182..2206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1686..1700
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1756..1772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2206 AA; 246162 MW; C64CFAE661B33972 CRC64;
MTMSLNEKRM LDREALRSVI QQWNANRLDL FELSEPNENL EFHGVMRFYF QDVGQKVATK
CIRVASDATV ADVIETLIEK FRPDMRMLSV PNYALYEVHA NGEERKLNPD EKPLLVQLNW
HVDDREGRFL LKDLDQKPTT LDNNTDTNFK RKLSKREKKE QKKKEKLQKL NPNGEDSENH
VAEKLYTELP ETSFTRSISN PEAVMRRRRQ QKLEKKLQQF RARDGGPDTG GTLKIYGESL
CRDVPYKTLL LSIRDCAQAV VREMLAKYGM DKADPLHYCL VQVNSDGSEY ILDDDECPLS
ILMNHPTSRG SIMFHVRRRP AADTSQPRRR KKKPLGISNG SGNMSAEREG PVLIEITHSG
DGGRRLKLTT EPVEVGSANT NALQLFGPSI QPRHCLISLH EGVCTVTPLH ADGLTFVNGH
HITQPTILHN GSVVMFGRAA SYRFVDVPSD GRYNLALSQS QLDSAYLYEN RSSTNPPSWH
EEEDASIASS SYSKKQHQQA FPQQQQKQLQ LAQPPQLSHL QQQQQQKNAL TQSQHSPGSN
ELKTTTNQQP SDDKSLFEND SGNMENETKS VSSMRSQDSR PQSFAKPPAG MSATPTMEPQ
GQEAILPAVL EFPEHHQEQF LKQVISELDV NSPNFKLAPV YTLYLCARYR ASTHYRPDLQ
PTERAHKLTV FLHHVANLIH NVIQEKYNDP KILSFWMANS SEFLHFLKSD RHISAFSVQA
QEVLAECVQT AFQNLVSIFH SELSQTLNQF LSENIDHDSA AGLVLSVLGS AMALLRRCRV
NAALTIQLFS QLFHYINVVC FNKFVTTSHM CTSTWGKALS DRLSLLELWA EKQGLELAAD
CHLAKINQCA EFLQAPKTNV TEVQQLACSC FRLNSLQMAA LLSQETIPRT LIDATVRMAE
SVADELTRAD GREIRLEESP DLPLALLLPV DGFSCDVVRG IPAGLVDFLS PYQVAGMCRL
ASQLTSIGLW TVYMHQFNGR SPSVMSTKMP QPEVQTIKLH KNTNGMGLSI VAAKGAGQDR
LGIYIKSVVA GGAADADGRL QAGDQLLRVD GQSLIGITQE RAADYLVRTG PIVTLEVAKQ
GAIFHGLATL LQQPSPVIQR DESLHQYRLS QQPPPPLRPQ STLSLSQLLS SRRNSTPEMY
PGARRFSMSY SHEDILSNDQ LDQIHFDPRY RDYRSASSLN NSHNRTRSNS LNSMGGSGNI
FQNLQYRRMS SQSSPPLLGL GIGVGGSRNG SVGIGLGLGV TTPLVTQKRW DTNPSIFIEE
YQEVDQNKSK TESIKTESKS EKRNSSKETL YSSNESLQPL SESDIKSFGD LSKIPFIDDD
DSTESAPCRF MDIDVDDGTK TNGVASSSGQ RNACRKTVSF DVIASGPSAS GFYQHLFTHN
GGRRMSERDM TRVGADVKPS PAPGPQLLNS KSVPTLHHIG NASNKSRSVH SLVGPSNSAG
NINTASATDQ GFYQNLSVYR QQNQSQPNLG DNRSLSHQLT PLSMQQQQQQ QQISGSNTPT
STNIINRPAS AFFNNSNNNN VMNQQSPSTP NIPSTQSTST GNLMQQQPMV GFNQLPSSVI
QAPHAHISHP NLSGQSNINR PPMLPNKMIP QQQQQQSGGG NGGNFMRDIQ SQHSLRMTQQ
QMMAPSMPNI AHASGYANNI SASQSMQNMN QMSAQNFHPQ SPQKQLPPTA PKPQRHPMDE
PSQLQIQPQP QPPLPPSSTH PLFKSPITQQ PSTAQQQNST SATLSYNVNS NDVQSKAGYY
QQQPQQQSIN KSATSNPWER EERERENEMR REQLRHWRDQ QIVELSLLPS RSPQQEEQLK
TLVLERDFER RAQEEENEEE NEAQYQKNQE ILRLQPGNNN NVSIPPSQTS TAATRLKQVD
IKTMPTNISP SSEMIMNSND NFQTAPPIQP KSILKSTNAY NNSNPSSPSK HAKVTSFAPK
NQNLSEITMN NTNANQMLTQ INKEMSEMTI EYQAEETNGP MMPPPPPERG SSFAVMQHQK
VRTSNSNNSG NSANFTKLTF NDPQLMSNNI SGNVNNNNNS KFVPSTNNNE HSPMVMMSPT
TTTTVAGTFT AHQIQQQMNL INNNVGAFTR DNKRVSFHDH ENNNNNNINN NVEIIGEQDL
SMIREDPNRF IDETAAMLQS PQSPDGDTNW SIQVQSTPGV IGAQEVYRDP RQRRLAEQQQ
KKSEAPVPEK LTFKEKMKMF ALESGENTPK DKLKISRAQR DIDAVH
//
