ID A0A1J1HM94_9DIPT Unreviewed; 1503 AA.
AC A0A1J1HM94;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN Name=putative Synaptojanin-1 {ECO:0000313|EMBL:CRK88524.1};
GN ORFNames=CLUMA_CG002220 {ECO:0000313|EMBL:CRK88524.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK88524.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRK88524.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
CC -!- SIMILARITY: Belongs to the synaptojanin family.
CC {ECO:0000256|ARBA:ARBA00008943}.
CC -!- SIMILARITY: In the central section; belongs to the inositol 1,4,5-
CC trisphosphate 5-phosphatase family. {ECO:0000256|ARBA:ARBA00009678}.
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DR EMBL; CVRI01000008; CRK88524.1; -; Genomic_DNA.
DR STRING; 568069.A0A1J1HM94; -.
DR OrthoDB; 21647at2759; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR002013; SAC_dom.
DR InterPro; IPR015047; SYNJ1/2_RRM.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF257; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF08952; DUF1866; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR Pfam; PF02383; Syja_N; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SMART; SM01165; DUF1866; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50275; SAC; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 1090..1110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1137..1157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1169..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1194..1213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1234..1257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1263..1283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1366..1390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1397..1414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1434..1457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1469..1493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..453
FT /note="SAC"
FT /evidence="ECO:0000259|PROSITE:PS50275"
FT REGION 908..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1503 AA; 169329 MW; 2D3422393A70F1C2 CRC64;
MAMGKNYRIL EKNKPEQPHS IILEHRSRPE TLLFESQAVA NLSAQETEAV RKQYVKILDA
YGCLGVLQLN AGETTILYLV LVTGCFSVGK IADSEIFRIT QTQFVSLQHQ QPNEDKISEV
RKVLNSGTFY FSWNSSSEKP STSAQNFDIT LSAQRRRKTN ETDNRFFWNR MLHIHLLRFA
VECEFWLLKA MCGSIEIRTV YAGSRQARAV IISRLSCERA GTRFNVRGCN DEGYVANFVE
TEQAIYLDNE VTSYLQTRGS VPLFWEQPGV QVGSHKVKLS RGFEATAPAF DRHMTMMKSR
YGRQAICNLL GTSLIGSKEG EAMLSNEFQK HHEMSVHKDV PHIVFDYHQE CRGNQTNLSK
LKDRLEKCCG SFGLFFASSD DVNQEQYGTI RTNCLDCLDR TNCVQTFIGL EVLNEQIKII
GLADKKQTLS RFEEVFRQMW ISNGNEVSKI YAGTGAIGSI GAGAGSKIID GARSAARTIQ
NNLLDSSKQE AIDILLVGST LSSELADRAR ILLPTNMLHA PTPVLREMCR RYNEYVSPAE
LRVAIGTYNV NGGKHFRSVI YKDLSLIDWL APKNDAIIDI EHSDSVYDKM ADIYAIGFQE
IVDLNAGNIV AASSDNAKAW AEELQRVLSK DDEPYALLTS QQLVGVCLYV FVRPQLAKSI
RDVATDSVKT GLGGATGNKG AAAIRFVLNG TSFCFVAAHF AAGQSQVIER NADYAEITRK
IAFPMGRTLK GHDYVFWCGD FNYRIDMDKD EMKEILKTGD LKPVLENDQL RKQQEAGSVF
NDFLEGEINF PPTYKYDLFS EDYDTSEKAR APAWTDRVLW RRRIRQLDAD DPNFNPGKLL
FYDGQAALAA VKRKKNLQVC GINLSINLKT EDWVKQVERE IELCTTNCVQ LCEYIDVSSN
SDYNSLGIPL AGGEQTKKKP PARPPALPKS PQVTPKHHPR HTAGVINVNN IIRPQQSQPQ
PQLPERPCLP PRPKAMEQKS DQISPPSEQT TMEAETYQAP SAIYEEIQDD IKGRGNRKMA
SSRREEQSLL GHSRSNGTSI VSSRNDSTEP VRLTPAWEAQ NLPNDDLNFK GMTMERARLE
CEPPSDKFKL IFLILVLHGI GTLTPWNMFI TAKDYFVNYK LSANYTGQNN TVYIDNFLPY
IGFASQIPNV LFNWLNIFVN LGGDLTKRVV WSLVVEIIVF LITVILAMVD SSDWPGTFFW
VTIVSVVILN IAGGIFQNTA YGMAAKLPPK YTGAVVLGSN ISGPFASVIS ILSGSIWPSV
RKAAIYYFIT AMFVILLCFD TYFAMPLNKF YRYHELMSEK KQEKARRAGI NIKAHPPYYK
IFRQSFMQLF NVFFIFFVTL TVFPTVHSDI KQLGEGKFLG IVPRELFTSI TCFFTFNFFA
MLGSLATSWV KWPSPRFLII PVLARVVFIP LFLFCNYHPL SMERVLPVYI TNDYVYWTIA
IIMSFSSGYL SSLAMMYAPQ SQTNPQYQIT AGMMAAAMLI TGIFTGILFS YIFPSFVKVA
VNF
//