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Database: UniProt
Entry: A0A1J1HRM6_9DIPT
LinkDB: A0A1J1HRM6_9DIPT
Original site: A0A1J1HRM6_9DIPT 
ID   A0A1J1HRM6_9DIPT        Unreviewed;      1609 AA.
AC   A0A1J1HRM6;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   05-JUN-2019, entry version 13.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=CLUMA_CG004378 {ECO:0000313|EMBL:CRK90677.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Chironomoidea;
OC   Chironomidae; Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK90677.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRK90677.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; CVRI01000020; CRK90677.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 2.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000183832};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       51    203       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      715    956       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1022   1473       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1521   1587       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      329    349       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HRM6}.
FT   REGION      702    730       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HRM6}.
FT   COMPBIAS    703    730       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HRM6}.
SQ   SEQUENCE   1609 AA;  184731 MW;  4CE58F53A90ACB47 CRC64;
     MEESENNILS IKIVSVDHYN SFPIPNLDSN YSEFRNCSVK YVPVIRIFGI TQNKKKICAN
     VHGVFPYFYI PCAEIDHEKI TKLMNDLAEQ IDKSINTSLG QSSSKNQHIY RISLVKGIPF
     YGYHQNEHQF LRLQLYNPNL VKRTSNLLQS GTIMSKQFQP HESHIPYILK FFIDYNLFGM
     SYLHVPLQFV HARNPDDNTR YRKRSVSEIE VDFKAIHILN RLAATEESSA NKAANPGIES
     IWEDERQRRE VLEAAPPMES EISQERNCPA TKSDIFYQSI LREKVIEGSQ NSTMFEESFS
     NEIASSSVKD KKKTFNLKNF LDSSVYAAEF SQSSSTTSTT STSQQQETDM EMFSQYVKDE
     EEIIPQLDGV DDEEQQLSPS ELTKLRDHER NFHPQPGPSR LFIPPVRQTP SNDDANNQQI
     HSHLMELAKS FNKFPDNVEK VEDSPTSISD DDELVKSFYN QTMMIDEFEE SEESSEALTE
     EVLNKTVKME CDDDEVAVMK PSFDPPSPSD VMKRLEEFKI PKHSNPTLFY SNPKDVTKRK
     EVGHNLLEIP GKRLCDLETF KSSLFVDYEK LKEIKNERRR NEIVICPYND PPSYRDAVKW
     LKTGKTEKEE DESPVKDKRE KTIMMLEDDE EAEATLIPSS QPMEEATTTP EIIQSSLEKD
     SSTLSEFIED GLYLSYSARK KRMKKSFSRR FQEIMKAKVV EAEKVSSQSS SVSEVDKASE
     TPESSSSNHS IIVKDANIQE DSSSFNNSNC DITGPTLNNT YGFKMKLESL QSNNEHTDLT
     ILSMELHVQT RDEFKPNPEF DAVSAIFYSL DGYCGGSNKI VNGIIAFVDD KKNFRYIKQD
     VEVILVDSEM EVFEVFFQKI RDFDPDIIAG YEIETASWGY LVERGYVLNM NLNNALSRMP
     LDKGEKARSA QTLDDDEHHH DMGDYHSEQK IPGRIQLDVW RLMKHEIALT SYTFENISYH
     VLHRRYPKHS FSLLTSLWKQ PLKCWIVLDY YIDRAKTLIE ILQQLDLIGR TCELAKLFGI
     QFYEVLSRGS QFRVESMMIR IAKRRNYVPV SPSVQQRAHM RAPEYIPLIL EPESRFYNDP
     VIVLDFQSLY PSIIIAYNYC FSTCLGRVEH LAKASSQPFE FGAYQLRVTP KKLKFLIEND
     LITISPCGVA FVKASVREGV LPRMLSEILS TRLMVKQSMK IHKNNSALQR VLHSRQLGLK
     LIANVTYGYT AANFSGRMPA IEVGDSVVSK GRETLERAIN LVETNKKWGC RVCYGDTDSM
     FVLVPGRSRE EAFKIGAEIA DAVTNDNPHP VKLKLEKVYQ PCILQTKKRY VGYMYESADQ
     KDPIYEAKGI ETVRRDGCPA AVKMLEKTLR ILFETYDVSK VKEYVCRQFR KILAGRCSIQ
     DLLFAKEFRG INGYKERASV PALTLTRKWK ASDSRNEPRR GERVPFLIVN GAPGLPLIRL
     VRSPLEVLND ENYKINSIYY ITKAIIPPLN RCLLLIGANA FEWFTELPRC QQFIPLLGQQ
     SKFDTTTRKG TISQFFSTSS CVTCENPCQE NVCSNCKSDS QKTVLAITMK SLNMERKLSS
     IKSICDSCCR RNFDTDCISL DCPVLYASYR AKRDYKQVQY LREVLDDEF
//
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