GenomeNet

Database: UniProt
Entry: A0A1J1HT32_9DIPT
LinkDB: A0A1J1HT32_9DIPT
Original site: A0A1J1HT32_9DIPT 
ID   A0A1J1HT32_9DIPT        Unreviewed;      1095 AA.
AC   A0A1J1HT32;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   05-JUN-2019, entry version 14.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=CLUMA_CG003111 {ECO:0000313|EMBL:CRK89353.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Chironomoidea;
OC   Chironomidae; Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK89353.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRK89353.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CVRI01000012; CRK89353.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000183832};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      117    467       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      532    962       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1000   1073       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     30       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HT32}.
FT   REGION       52     75       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HT32}.
FT   COILED      484    504       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS      1     19       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HT32}.
FT   COMPBIAS     52     66       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A1J1HT32}.
SQ   SEQUENCE   1095 AA;  125086 MW;  2381A69FE03DA4B8 CRC64;
     MNSKANKSKF SAGSSSQQPK KKFKVDDEDE DFGSQFEADL AMMEADDVDH EIVKGEGPEN
     KETNQKWSRP DLPPINPKTD SVVFQQIDVD HYNGLPMHGM PGAQIPPVPI FRMYGVTMEG
     NSVCAHVHGF APFLYVQAPP NFNKSHLSDF KSSLDEIVIK DIKNNKEKIQ EAILSVELIQ
     KQSIHFYIGE DKSNFIKITV VLPKLIAAVK RLLEREIVMS DMNFQDCRCF ESNIDFDIRF
     MVETKVVGCS WITLPPGTWQ LREKGKKPEP ESRCQLEVDV AYDKFIAHEP DGEWAKVSPL
     RILSFDIECA GRKGVFPEPQ HDPVIQIANM VMRQGEKEPF LRNVFTLNTC APIVGSQVLS
     FKNEKDLLEA WSDFVRQLDP DILTGYNINN FDVPYLLNRA AHLKVKNFEY LGRIKNIKSV
     IKETMIQSKQ MGRRENKQVN FEGRVPFDLL FVLFRDYKLR SYTLNAVSYH FLQEQKEDVH
     HSIISDLQNE NEQTRRRLAM YCLKDAYLPL RLLNKLMCIV NYMEMARVTG VPLACLLTRG
     QQIKVVSQLL RKARDAGYLI PTYTSQGGDN EQFEGATVIE PKRGYYSDPI STLDFASLYP
     SIMMAHNLCY TTLLRPIDKN RLELKDDDVT KTPAGNFFVK SNVRKGLLPE ILESLLSARK
     KAKNELKSET DPFKRSVLDG RQLALKISAN SVYGFTGAQV GKLPCLEISG SVTAYGRTMI
     ELTKQEVEQK YKMSNGYEND AVVIYGDTDS VMVKFGTSSL DRAMELGKEA AEFVSAKFIK
     PIKLEFEKVY FPYLLINKKR YAGLYWTSPD KYDKMDCKGI ETVRRDNSPL VANLMNMCLQ
     KLLIDRDPNA AVDYAKSVIS DLLCNRIDIS QLVITKELTK HEYTAKQAHV ELAAKMKKRD
     AGNAPKLGDR VPYVITAAAK STPAYQKAED PIYVLENCVP IDFQYYLENQ LSKPLLRIFE
     PILGDKAESI LLRGDHTRTR ASATSKVSAL SSFVQRRETC LGCKTVLPKE REKLALCQHC
     ESKQAELYQH EIMQQHQLEE RFSRLWSECQ RCQGSLHEEV LCTSRDCPIF YMRTKVKMEL
     ETQHKRVMRF GLPAW
//
DBGET integrated database retrieval system