ID   A0A1J1HUP0_9DIPT        Unreviewed;       803 AA.
AC   A0A1J1HUP0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=CLUMA_CG004772, isoform A {ECO:0000313|EMBL:CRK91084.1};
GN   ORFNames=CLUMA_CG004772 {ECO:0000313|EMBL:CRK91084.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK91084.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRK91084.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
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DR   EMBL; CVRI01000020; CRK91084.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J1HUP0; -.
DR   STRING; 568069.A0A1J1HUP0; -.
DR   OrthoDB; 1429709at2759; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 6.10.250.1760; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   InterPro; IPR032476; CPT_N.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   Pfam; PF16484; CPT_N; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        55..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..47
FT                   /note="Carnitine O-palmitoyltransferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16484"
FT   DOMAIN          174..774
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        471
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   803 AA;  92861 MW;  7070FD3C2DA3E0E5 CRC64;
     MAEAHQAVAF SFSITHEGWN VNYDREVLNL VWDSGVRSWK KRIARLKSGV RNGVYPAHLE
     SLWVLMGLVT LFHYINKRIP YDLVNTFMAF MPSNSHFWQL LMCNLVALIY WITACLTMRY
     TLKLLLMYKG WMYESRGSGS RVSLSTKLWA VLVKVFKKWN NPGLYSFQSS LPRLPLPSVK
     DTMSRYLRSV RPLLDDETYE KVKSEADEFE KGIGKKLQRY LLLKSWWSTN YVSDWWEEYV
     YLRGRSPLMV NSNFYGIDAI FAHPTKNQAA RAASVCHLLL QFRRQVDRQE LEPIMVQGLV
     PLCSWQYERI FNTVRVPGVE GDKIVHYKDS NHIVVIHKGC YYKMIIYHKG RLLKPCELQH
     QFEHILSNKA TPLHGEEFLA ALTAWDRTKW ANAREKYFAK GINKVSLFLV ESAAFVISLD
     DEPYEFDIAQ PEKLDQFGRK MMHGKGTDRW FDKSFTVCVA SNGRIGFNSE HTWADAPVMS
     HIWEGIIVDE NEPTRADAPI MGHLWEHCIF DDVNYGYDEN GKTHGKPEIL PPTPTRLQWD
     FHSEQLLKTI DEAYDDAQKV LNDVDLRIFV HDAYGKGFMK TCRISPDAYI QMALQLAYYR
     DYGKFSLTYE ASMTRLFREG RTETVRPCTI ESSAWVRAME DKTSNATERV RLLNEACKRH
     QIGYQDAMCG RGIDRHLFCL YVVSKYLEVD SPFLKEILSE PWRLSTSQTP HGQTPKMDLK
     KNPHCISAGG GFGPVSEDGY GVSYIIAGED LLFFHISSQK SCKVTDSERF AQQIGKALSD
     IKVLFEQYKL EQKKEVYQNG SAD
//