ID   A0A1J1HYH3_9DIPT        Unreviewed;      1715 AA.
AC   A0A1J1HYH3;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   08-NOV-2023, entry version 23.
DE   SubName: Full=CLUMA_CG006605, isoform A {ECO:0000313|EMBL:CRK93003.1};
GN   Name=putative Tuberin {ECO:0000313|EMBL:CRK93003.1};
GN   ORFNames=CLUMA_CG006605 {ECO:0000313|EMBL:CRK93003.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK93003.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRK93003.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CVRI01000036; CRK93003.1; -; Genomic_DNA.
DR   STRING; 568069.A0A1J1HYH3; -.
DR   OrthoDB; 20915at2759; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR003913; Tuberin.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   PRINTS; PR01431; TUBERIN.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832}.
FT   DOMAIN          1462..1688
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          935..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1170..1273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        935..959
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1212..1240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1241..1273
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1715 AA;  196428 MW;  263A0E34A49E6756 CRC64;
     MNKNLDKLKQ FFRSNKTNSS QEKVYILNHE NENDLRRETI EKRIKLLRDL GDIVMSHRLE
     EYAIQKLWSL TSDLIEPQNN FEARQAALIF YTKLIQGQYR DLSMMRMHFF RLIQNHNVPI
     DLPYCLQMFK ALTDNGRDIQ NFEEEIGIFM LKWIDQIIEG HLTAPYLELV VNIIKFNTAY
     IDREVIVGIV HRVCNDVCIQ FMNDQATFLQ CLFVIETVIC YTVFPNEILA PCIIVLCRAV
     KTQAYLETSY RIMRNLLGTQ LGYASLLTMT SMLNESRYYI DSQVLRGAVF HTNMNLWGGN
     NSSLQNGIKY SSTVLSSYLK ALQSNHTIVT LEVIISIQTL LNKCGNDLSE PSWDIVVDIL
     ERIRENMMRD QIPSDLDLRF HNIIDRIEVL IDKNLLNADV NKIYNLIEKI SNRRPESSVM
     KLISFRVSQI SPVQLGWLEK LAHLMERFYR KEINQNVRIS MIEHLKEIIN INRICYEDEI
     LEKIVIVTFC DISQELDMKV RVAACKLLLD ICSHCDTKRC LELFDILEKV INHPFDVYNL
     ESKITKNEND FEDAIAVVNG LINLFLEKLY QLPSNHAVRI YYILIGHLET HYIYPKVFEN
     IVQVRYTIIN WMLKIRANSC YQIGYPTPRL ISDQFKFTHY ISIDGDHHHH YHQYHQQSVT
     PSTQDIPPND ERSLDGYGLS NVTTLSFRRG WDIIVKCLNM DKDWPMVQLV LRELPKIMQN
     KTLIRGNDID GLGNALVSLF KGNYTKEKFI EHFTTSNEQK DFRALMIPAV ASLITYNTLS
     IPTKKKIVEV LKSELRIDGN LSICLQAFTI LLIEKCEIFE RQLGDIILTL TKVSDTVNVA
     IPILEFLSTL AHLPYPTNLS QKQFSYVFVT CLPYTSPARY DHYTVSLAHH IIATWFLKSR
     IMWRKIFADY IIEGIAKNIE KSIRDAKVQQ AHAIPDQDVK ELRNEDSSLR KRSSSLTEQS
     SRRREVNNPQ VLKMKQKMQS LQQATINNFD MDAFHIELIE TCIDFMARNT FSQSSALPRR
     LPAADFLLRG GGQTKTWVVG HNIVTITTSA CMGNHDWKSC ACYCSDWAEI TIRKPSSMVS
     WIMKFENQIG TFANDFSFHD LTALFSDKEI DPGNSNGILI RKRNEESDNS LVDELPLEKS
     IENITVQEDI KENIIPLQFT ASDSSVGSYM TQPINIPSKQ ETEEGNIAGD DEISYDGEEC
     DDPKRNPVRR VNSSPEMRSN WKINLNNKSS KESKSGSSSN DTVSDDHEET TKPVELEIQQ
     KKKSSYSKET KVSCEAIPEE VITSGQKEDG NEKSLTTRPV QLLSSISAQE TPNVASVPKK
     QHSADDTFQL RRSESNTSQA GQVKNNEWGS VASSNLPLSP RYGKHALVTR QVSHQAQVEN
     DEMGIRARSK TISVIGGNKE AYMKHGNNSD FSVSTSSFDQ SQQSTLATSG ISPSFVFVQL
     FSSGKINSSE IIPVTEKHMV TLNLLDFIPP YEIHKIGVLY VTQGQANNEA EILRNRSGST
     RYIQFLHNLG SLIAIKDAKE EKLFVNMEAP REGNFTYVWH DDIIQMTFHV ATLMPTLESD
     PNCHEKKKYI GNDYVTIVYN DSGEDYALNT IKGQFNYACV IVQPLELGTN LVSVRAKGDI
     EDFFKHLEPM IISDRGAPLL ARQLALHANM ASLVSTSLKN RSVSPYANNW LERLRKIKHL
     KSKLINETKQ DNQQPTLNNT SNTLNFLKDV FTKYS
//