ID A0A1J1HZF7_9DIPT Unreviewed; 2166 AA.
AC A0A1J1HZF7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN ORFNames=CLUMA_CG005540 {ECO:0000313|EMBL:CRK91926.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK91926.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRK91926.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; CVRI01000021; CRK91926.1; -; Genomic_DNA.
DR STRING; 568069.A0A1J1HZF7; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 5.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 133..160
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 397..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 791..815
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 836..859
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 865..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 920..942
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 962..979
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1000..1021
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1296..1314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1335..1357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1363..1389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1410..1430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1465..1488
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1572..1595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1688..1707
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1719..1738
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1783..1805
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1876..1895
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1912..1947
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 38..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2036..2132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 422..460
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 655..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1233
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2038..2059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2166 AA; 244831 MW; C69A36211236BCCB CRC64;
MSDDSSSLLE EERSLFRPFT RESLLAIEAR IADELEKQKE LEKRKAEGEI RYDDEDEDEG
PQPDPTLEQG VPIPVRMQGN FPPELAATPL EDIDSFYANR KTFVVVSKGK DIFRFSATDA
LWLLDPFNPI RRVAIYILVH PLFSLFIITT ILTNCILMIM PSSPVVESTE VIFTGIYTFE
SGVKVMARGF ILQPFTYLRD AWNWLDFIVI TLAYVTMGID LGNLAALRTF RVLRALKTVA
IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI RRWEFRGEEW
GNYTPKVWND FCENRTNWYF GDAEPLDPPL CGNSSGAGQC EEEYICLQGF GPNPNYNYTS
FDTFGWAFLS AFRLMTQDYW ENLYQLVLRS AGPWHMLFFI VIIFLGSFYL VNLILAIVAM
SYDELQKKAE EEEAAEEEAL REAEEAAANR QAKIEAHAAA AAAAAQAANE PDHIAKSPSD
FSCHSYELFV GQEKGNDDNN KEKMSIRSEG LESVSEITRT TAPTALASAK ARKVSTTSLS
LPGSPFNLRR GSRGSHQFTI RNARGRFVGV PGNDRKPLVL QTYLDAQEHL PYADDSNAVT
PMSEENGAII VPVYYANLGS RHSSYTSHQS RISYTSHGDL LGGMTKESRL RGRSRNSHAV
IQQQPTSASS YADTNHKGHR EYSLQEMSQD CTDEAGKVKS SNPFIEEPAQ SNTLVDMKDV
MVLNDIIEQA AGRHSRTSDH GVSVYYFPTE EEEDDEDGPT FKEKMLEASL KGIEIFCVWD
CCYCWLKLQE WIAWLVFDPF VELFITLCIV INTLFMALDH HNMDKDIEKI LKSGNYFFTA
TFGIEASLKL IAMSPKFYFQ EGWNIFDFII VALSLVEILL DGVQGLSVLR SFRLLRVFKL
AKSWPTLNLL ISIMGRTMGA LGNLTFVLCI IIFIFAVMGM QLFGKNYHDN VSKFPDGDMP
RWNFTDFMHS FMIVFRVLCG EWIESMWDCM YVGDVSCIPF FLATVVIGNL VVLNLFLALL
LSNFGSSSLS APTADQETNK IAEAFNRISR FKKWVKQSIM NGLRKLKNKI TNQISVQPSA
IAKRICPCIP LEHGDNELEI SGDDILVDGL IKKGKGENQL EVAIGDGMEF TIHGDLKTKG
KKNKLMNNTK MIGNSITHQD NRLDELNHRG MSLQDDDTAS IKSYGSHKNR PFKDESHKGS
AETMDGEEKR DVSKEDLGID EELDDEGEEE EEEGELGHHG IINAEEDEVI EETPADCFPE
HFYTRFPFLA GDDDAPFWQG WVNLRLKTFQ LIENKYFETA VITMILLSSL ALALEDVHLI
KRPILQDILY YMDRIFTVIF FIEMLIKWLA LGFAVYFTNA WCWLDFVIVM LSLINLGAIM
AGAADIPAFR SMRTLRALRP LRAVSRWEGM RVSLINFIAS LCGVGGIQAF KTMRTLRALR
PLRAMSRMQG MRVVVNALVQ AIPSIFNVLL VCLIFWLIFA IMGVQLFAGK YYKCMDANGT
TLSQEIIPNR SVCIAENYSW ENSPMNFDHV GKAYLCLFQV ATFKGWIQIM NDAIDSRDVN
LQPIRETNIY MYLYFVFFII FGSFFTLNLF IGVIIDNFNE QKKKAGGSLE MFMTEDQKKY
YNAMKKMGSK KPMKAIPRPR WRPQAIVFEL VTNKKFDMII MLFIGLNMLT MTLDHYKQTD
IFTLILDYLN MIFICIFSTE CLMKIFALRY HYFVEPWNLF DVVVVVLSIL SLVLSDLIEK
YFVSPTLLRV VRVAKVGRVL RLVKGAKGIR TLLFALAMSL PALFNICLLL FLVMFIFAIF
GMSFFMHVKK KSGIDDVYNF ETFGQSMILL FQMSTSAGWD SVLDGIINED ECDPPNPEIG
FPGNCGSAKV GITFMLSYLV ISFLIVINMY IAVILENYSQ ATEDVQEGLT DDDYDMYYEI
WQQFDPDGTQ YIRYDQLSEF LDVLEPPLQI HKPNKYKIIS MDIPICRGDL MFCVDILDAL
TKDFFARKGN PIEETGDFEG VNTRPDEVGY EPVSSTLWRQ REEYCARLIQ HAWRKHKQHA
THDGDGQGTG DENETGDEHE GGAGGAGLGS SHSHNELGGG GSLGSGTLLN RNNSRNDKTT
HNNKNSSNNT INASDGKITP KDVGSSEQLG RQTTVVVESD GFVTKNGHRV VIHSRSPSIA
SRSADV
//
