ID A0A1J1I005_9DIPT Unreviewed; 520 AA.
AC A0A1J1I005;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=CLUMA_CG007137, isoform B {ECO:0000313|EMBL:CRK93605.1};
GN ORFNames=CLUMA_CG007137 {ECO:0000313|EMBL:CRK93605.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK93605.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRK93605.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR EMBL; CVRI01000037; CRK93605.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J1I005; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:InterPro.
DR CDD; cd15900; EFh_MICU; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 262..297
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 453..488
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 111..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 59545 MW; B560A26E26E57DD7 CRC64;
MSSLRFCGAL LAKNTILSQS KIVPMTVPIG FKVRDASKST FRQEHYRGFK NFGHKPTPVP
GVTKAFHFFI GFSLFLCLLD WKGLLGYEAG ENFFSMPRVD CEAKIKPEKE KLDKAEDAKD
IKDSSEDESS SDSESETSGE EPKKKRVKEK VGFRDRKIIE YENRIRQYST PDKVFRYFAT
IQVPHGDSYE PFMTPLDFLT SMTPGIKQPE GLGLDQYKKY DPKNVSQRLD LKLEEDSIFY
KLGSYGLISF SDYIFLLTVL STSRRHFEIA FKMFDLNGDG DVDSSEFEEV ANLIRQQTSI
GSRHRDHANT GNTFKGVNSA LSCYFFGTKL DQKLKIEKFL DFQHQLQREI LTLEFQRKNP
DDNGNISEAD FAELLLAYAG YPPKKKVKKI KRVKKRFRDH GTGISKEDYL NFFHFLNNIN
DVDTALTFYH IAGASIDQLT LKHVAKTVAL VDLSDHVIDV VFTIFDENMD GQLSNREFVA
VMKNRLLRGL EKPKDTGFVK FMHSILKCAK ETKPVLLDVL
//
