ID   A0A1J1IE18_9DIPT        Unreviewed;       931 AA.
AC   A0A1J1IE18;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=CLUMA_CG011858, isoform A {ECO:0000313|EMBL:CRK98501.1};
GN   ORFNames=CLUMA_CG011858 {ECO:0000313|EMBL:CRK98501.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRK98501.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRK98501.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC       1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; CVRI01000047; CRK98501.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J1IE18; -.
DR   STRING; 568069.A0A1J1IE18; -.
DR   OrthoDB; 4126787at2759; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 2.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR   PANTHER; PTHR11767:SF113; INWARDLY RECTIFYING POTASSIUM CHANNEL 2, ISOFORM D; 1.
DR   Pfam; PF01007; IRK; 2.
DR   Pfam; PF17655; IRK_C; 2.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; E set domains; 2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM        150..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        618..641
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        700..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          116..268
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          275..447
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   DOMAIN          584..729
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          736..908
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   REGION          474..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..514
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   931 AA;  106830 MW;  6E3DA1D57744FD43 CRC64;
     MLMKKRNPEN MAYLTPESET STTADLSWSN LISTDKPRNI IVRIDDIPKE INPEEEQLNA
     PDNFHRNHRE RKESLMGTFH RHLRMSLKAV SESPGPLTRY RQTRFSSRRV RKRVIFKHGD
     VNVVQGKVSK RRRRYLQDIF TTLVDIQWRW TILIFALNFM LSWFFLALLW YAIAVAHGDI
     EYFDLMSKSS NAEEFESKSN HTPCVTEIKS FLSAFLFSLE TQHTIGYGHR YITEECPEAA
     FVLCLQSITG VFFQAFMVGT VFAKLSRPKK RAQTLLFSRN AIICHRDGVP CLMFRVGDMR
     KSHIIEAHVR AQIIRKKVTK EGELLPFFQE ELAVGADGSD DRLMFIWPTL IVHKIDENSP
     LYDLTAQDMI KDRFEIVTML EGVVESTGMT TQARSSYLPS EILWGHRFES VVQFKRETGE
     YEVDYTLFNN TYEVDTPLCS ARQLNEARAE TQLQQGEIDQ FNPAFNIHPI PASISLETPK
     DSDNTNDFNL PNGELPNQSQ TSSSSSTTLP ISPDEKKPLT QIVIPKQKSK NDGNLSSLDN
     VISNLPLTIV PSIAKNLSSQ ASENLRNRTL RPGTAKKYRK RAILKNGECN IVQSKLSQKR
     LRFLQDIFTT FVDTQWRWTL LTFGLSFILS WLFFAVIWWL IAFTHGDFEE SHLPDNQADS
     GWSPCVYNIH SFTSCFLFSI ETQHTIGYGV RTTTEECPEA IFIMCFQSIY GVMIQAFMVG
     IVFAKMTRPK HRTQTLLFSK YAVICQRDGE LTLMFRVGDM RKSHIIGANV RAQLIKTKLT
     REGEIIGQYQ TELDIGTDGC SSDLFFIWPM VVCHKINATS PLYNMSASDL LQQERFEIVV
     ILEGTVESTG QTTQARSSYL ACEILWGHRF EPVVTYNREK QGYEIDYSKF NAAQQVDTPL
     CSARELTDYY KLQDELKTPV DVKFSIGPKN E
//