ID   A0A1J1IM37_9DIPT        Unreviewed;      1102 AA.
AC   A0A1J1IM37;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN   Name=putative Guanylate cyclase 32E {ECO:0000313|EMBL:CRL01311.1};
GN   ORFNames=CLUMA_CG014428 {ECO:0000313|EMBL:CRL01311.1};
OS   Clunio marinus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Clunio.
OX   NCBI_TaxID=568069 {ECO:0000313|EMBL:CRL01311.1, ECO:0000313|Proteomes:UP000183832};
RN   [1] {ECO:0000313|EMBL:CRL01311.1, ECO:0000313|Proteomes:UP000183832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436};
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DR   EMBL; CVRI01000055; CRL01311.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1J1IM37; -.
DR   STRING; 568069.A0A1J1IM37; -.
DR   OrthoDB; 1493914at2759; -.
DR   Proteomes; UP000183832; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          394..700
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          768..897
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1081..1102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1102 AA;  125978 MW;  2937EC43EBD56959 CRC64;
     MSTICLIICL KSCADVVVTN KTLFPTFSRT SLGPPEKISK SVIALLKAYQ WNKFVIVADT
     RQWTKEITLA IKELAGKNKL NVTDVKYFTD YIRAKYEHMQ NIISESFRKT RIYVFVGGPW
     ALDDFMLCLQ ERKLLDAGEY MVVSVNDEFY NPDLKMVQGV RQNNILSHPF LSRFKNKALN
     AKSYQSILQI TLTAPSVDLT NFYREIREKA KKFNIPYHSK IAPVISVRAA YLYDAVIIYA
     QAATKMLSSG GDLRDGRTLM QKYVFNNMYT SKQGFQVLID ENGNAEGNFS VFSMQYINET
     AMTMQQVGSF VSSSNNASRT ELPKFQLSET KNILWINGIP RDEPKCGFDG CPSDWSFLIS
     SLLVFLFVAL VSAFLLKHYR YEQKLQSIMW KVDIREITFL GKEYNEEAYR TGNMTQYFRH
     RTMSLITGDT GRRAYTTIGF FRGNFVALKK VHKRSIDLTR SIKKELKLMR ELRHENIVTF
     IGASVESSNI YILTNYCARG SLENVLANQD LKLDHLFVSS LVFDIMKGLI FLHDSEIVSH
     GNLRSSNCLV DSRWCVKLSD FGLNEFKLGS DEPDKSEKEI KRNICRSPEL LRLHNPPSYG
     TQKGDVYSFA ILLYEIYGRK GPFGFGHAYD SETLAATYKE IIEKIINPPN PMMILRPPLH
     ILDAPECVKQ SIVLCWNEEP DDRPDMRLVR IKLKELQGGL KSNIFDNMMA LMEKYAYNLE
     ELVQERTTQL SEEKKKTENL LLRMLPRSVA ESLMHGERVV AECFDCVTIM FSDLVGFTEI
     CSTSTPLEVV EMLNDLYSLM DSIISNFDCY KVETIGDAYM VVSGLPIRNL DHASQIASLA
     LMILNRASKL EIRHRPGELF QIRIGIHSGQ VVAGCVGLKM PRYCLFGDTV NCASRMESTS
     EPRRIHVSTA TYGLLKKTGR YICEERGLTF IKGKGEMRTF WLKGEDKSKI VEAPKKLKID
     DWNKTPDLLC IDNIRLAVKR NHDFCERNFA TKSLSNINHS YLFSSLMEHK FVENLPSLGI
     SKNFPSHDCY LCQKKKYLYQ KYHQELRHRC EKFCSSSNYV ASFSSSSEIE VAVNECSCSR
     VSQNPSIPSR SPSSAPQIIF TE
//