ID A0A1J1ITH8_9DIPT Unreviewed; 674 AA.
AC A0A1J1ITH8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=CLUMA_CG015147, isoform A {ECO:0000313|EMBL:CRL02414.1};
GN ORFNames=CLUMA_CG015147 {ECO:0000313|EMBL:CRL02414.1};
OS Clunio marinus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Clunio.
OX NCBI_TaxID=568069 {ECO:0000313|EMBL:CRL02414.1, ECO:0000313|Proteomes:UP000183832};
RN [1] {ECO:0000313|EMBL:CRL02414.1, ECO:0000313|Proteomes:UP000183832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; CVRI01000057; CRL02414.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J1ITH8; -.
DR STRING; 568069.A0A1J1ITH8; -.
DR OrthoDB; 3675269at2759; -.
DR Proteomes; UP000183832; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF36; IONOTROPIC RECEPTOR 68A, ISOFORM A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000183832};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..344
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|Pfam:PF10613"
FT DOMAIN 390..611
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
FT REGION 654..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 78190 MW; 7C04A9268F842E46 CRC64;
MLVFKSLFVL LTISTIFAFN FTNFLNDSFY VLKDEIETRE IQDDIIDLIS SILIKFKVSK
VSIITDSIYK GHLINTNLID SLEYKIIFMM SIKDSEAFDE KPSGNIETML RIMKREIIDA
YVILITNGIQ MSSFLKFADY YRLLNSQALI ILLHDYRLLS PNFHYLWKRI VNVILIRKCE
TIHKDMYEIL TVPFPEKIRE ILVLSTINYW SPLRGFKWKH KIFDTRAKNN QLNGVELNIV
VLEHTPTVFK QLEENETIGY YGLEIDLITT LSSVMNFSTN FYESEDAITE KWGKKVSQAI
FSGMLNEMDQ SRADIAIADL HYTSFNLDIM DLSLPYNVEC LTFITPETLG DNSWKTLILP
FSFEIWIGVL TSGKPTEKLQ YFIKDLFDEF SACILYTYSM ILVVSLPRLP FRWSIRVLTG
WWLIYCLLVV VAYRAALTSI LANPQPRLTI DTIEMLANSL LKCGAWGEQN KNIFLSSSDP
ASQKIGTKVE HIDNADKAIE QVAQGEFAYF ENRFTLQQLR MQHEQQKDSI QNLHIMDECV
INMPISIGIE KNSPLKEQID KFIRYIIEAG LIKKWLMDSV KGFESNTESQ PEEALMDLKK
FSGALVALVC GYVFAILVFT IEKCYWKFII EKHPYYDKYF RAIKLPKIKN TEPQKITKSK
RPMTSDKKNH AVLN
//
